Keep Current with the Latest in Cell Biology Research

Five Harvard Medical School Faculty Named HHMI Investigators

[Harvard Medical School] Five researchers from Harvard Medical School have been named among 26 new HHMI Investigators by the Howard Hughes Medical Institute (HHMI).

Shifts in Receptors during Submergence of an Encephalitic Arbovirus

[Nature] Investigators identified protocadherin 10 (PCDH10) as a cellular receptor for Western equine encephalitis virus (WEEV). They showed that multiple highly virulent ancestral WEEV strains isolated in the 1930s and 1940s, in addition to binding human PCDH10, could also bind very low-density lipoprotein receptor and apolipoprotein E receptor 2.

Glycan-Shielded Homodimer Structure and Dynamical Features of the Canine Distemper Virus Hemagglutinin Relevant for Viral Entry and Efficient Vaccination

[eLife] Scientists determined the crystal structure of the globular head domain of canine distemper virus-hemagglutinin (CDV-H) vaccine strain at 3.2 Å resolution, revealing that CDV-H exhibited a highly tilted homodimeric form with a six-bladed β-propeller fold.

Cytomegalovirus and Epstein–Barr Virus Infections in Patients with Neuromyelitis Optica Spectrum Disorder

[Journal of Neurology] Serum immunoglobin G antibodies against cytomegalovirus and Epstein–Barr virus were measured in patients with neuromyelitis optica spectrum disorder and healthy controls.

Hepatitis E Virus: From Innate Sensing to Adaptive Immune Responses

[Nature Reviews Gastroenterology & Hepatology] The authors summarize key components of the innate and adaptive immune responses to hepatitis E virus (HEV), including the underlying immunological mechanisms of HEV associated with acute and chronic liver failure and interactions between T cell and B cell responses.

Generation of Antitumor Chimeric Antigen Receptors Incorporating T Cell Signaling Motifs

[Science Signaling] The authors developed chimeric adaptor proteins and CAR tyrosine kinases in which the intracellular ζ T cell receptor (TCRζ) chain was replaced with intracellular protein domains to stimulate signaling downstream of the TCRζ chain.

rhIL-7-hyFc, a Long-Acting Interleukin-7, Improves Efficacy of CAR-T Cell Therapy in Solid Tumors

[Journal For Immunotherapy of Cancer] CAR-T cells targeting GPC2, GPC3, and MSLN were used in combination with NT-I7 to assess the anticancer activity.

Systemic and Skin-Limited Delayed-Type Drug Hypersensitivity Reactions Associate with Distinct Resident and Recruited T Cell Subsets

[Journal of Clinical Investigation] The authors leveraged recent technical advancements to study skin-resident memory T cells (TRM) versus recruited T cell subsets in the pathogenesis of severe systemic forms of disease, SJS/TEN and DRESS, and skin-limited disease, morbilliform drug eruption

TSP50 Facilitates Breast Cancer Stem Cell-Like Properties Maintenance and Epithelial-Mesenchymal Transition via PI3K p110α Mediated Activation of AKT Signaling Pathway

[Journal of Experimental & Clinical Cancer Research] TSP50 was negatively correlated with the prognosis of patients with breast cancer. TSP50 promoted CSC-like traits and EMT in both breast cancer cells and mouse xenograft tumor tissues.

Discovering Cancer Stem-Like Molecule, Nuclear Factor I X, Using Spatial Transcriptome in Gastric Cancer

[Cancer Science] Researchers identified Nuclear Factor IX (NFIX) as a critical regulator of cancer stemness in gastric cancer and evaluated its clinicopathological significance and function.

Polyploid Giant Cancer Cells Induced by Docetaxel Exhibit a Senescence Phenotype With the Expression of Stem Cell Markers in Ovarian Cancer Cells

[PLOS One] Ovarian cancer cells were treated with Docetaxel (Doc), and then the effect of Doc on cellular viability was evaluated by MTT assay and microscopic imaging analysis.

Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

[Molecular Cancer Therapeutics] Investigators generated HOTAIR knock-out high-grade serous ovarian cancer cell lines using paired CRISPR guide RNA design to investigate the function of HOTAIR.

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