[Advanced Functional Materials] Utilizing electrospinning, polycaprolactone (PCL) substrates were fabricated to facilitate induced myogenic progenitor cell-differentiation into aligned myotubes by controlling PCL fiber orientation.

[Stem Cell Reports] Scientists presented a transgene-free method for the generation of purified, expandable myogenic progenitors from human induced pluripotent stem cells grown under feeder-free conditions.

[Nature Cardiovascular Research] Researchers showed that α-smooth muscle actin localized to the nucleus in wild-type smooth muscle cells (SMCs), enriched in the nucleus with SMC differentiation, and associated with chromatin remodeling complexes and SMC contractile gene promoters.

[Life Sciences] A competing endogenous RNA regulatory network was obtained through the application of osteoporosis-related high throughput data sets.

[Macromolecular Bioscience] Researchers leveraged a methacrylated hyaluronic acid hydrogel platform to study stromal cell mechanotransduction. Hydrogels were first formed through thiol-Michael addition to model normal soft tissue stiffness.

[Applied Biochemistry and Biotechnology] Investigators used proteomic analysis to explore the molecules that may contribute to the survival and proliferation of hypoxic preconditioned MSCs.

[Advanced Science] By single-cell RNA sequencing, bone marrow-derived MSCs were the most downregulated cell cluster, and coincidentally, Piezo1 expression was mostly enriched in those cells, and was substantially downregulated by unloading.

[Cancer Letters] The authors employed simultaneous two-step modifications to engineer MSCs and MSC-derived exosomes to create exosomes overexpressing the fused protein lysosome-associated membrane protein 2-interleukin 3 and hematopoietic cell E-selectin/L-selectin ligand.

[Cell Death Discovery] Researchers found that administration of antler stem cells improved the survival rate of pulmonary fibrosis mice and reduced lung fibrosis, collagen deposition, and myofibroblast differentiation.

[Phytotherapy Research] A diabetic cardiomyopathy mouse model was constructed, and the effects of ginsenoside RG1-induced MSCs on myocardial function and fibrosis in diabetic mice were evaluated.

[Cellular & Molecular Biology Letters] The authors provide a comprehensive overview of the biosynthesis and composition of MSC-Exos and their mechanisms of action in osteoarthritis.

[Cell] Scientists generated a single-cell transcriptomic atlas of the aged human prefrontal cortex covering 2.3 million cells from postmortem human brain samples of 427 individuals with varying degrees of Alzheimer’s disease pathology and cognitive impairment.