[Science] Scientists focused on PIEZO-mechanosensitive ion channels that help stem cells detect and respond to physical changes.

[Nature] Scientists reported that the intestinal epithelium undergoes expansion during pregnancy and lactation in mammals.

[Nature Communications] Investigators proposed a functional polymer-based xenogeneic-free dish for the culture of intestinal stem cells, ensuring substantially prolonged maintenance of intestinal stem cells derived from 3D human intestinal organoids.

[Nature Protocols] Scientists described their protocol for a human pluripotent stem cell-derived human cerebellar organoid model, which successfully replicated the cellular diversity of the fetal cerebellum along with some of its distinct cytoarchitectural features.

[Cell Reports Medicine] Researchers employed a genome-wide CRISPR knockout screen and discovered that the depletion of ubiquitin-activating enzyme E1 (UBA1) enhanced sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi) in homologous recombination-proficient ovarian cancer cells.

[Cell Stem Cell] The authors developed an arrayed screen of 14 morphogen modulators in human neural organoids cultured for over 70 days.

[ICU Patient-on-a-Chip Emulating Orchestration of Mast Cells and Cerebral Organoids in Neuroinflammation] The development of an Intensive Care Unit (ICU) patient-on-a-chip platform to elucidate the effects pf propofol and midazolam on brain tissue was reported.

[Journal of Cell Biology] Investigators showed that the kinetochore protein KNL-1 and its associated Knl1/Mis12/Ndc80 complex partners controlled dendrite branching in the Caenorhabditis elegans mechanosensory PVD neuron.

[Cell] Researchers demonstrated that RNA G-quadruplex assembly formed scaffolds for α-synuclein aggregation, contributing to neurodegeneration.

[Science] In aging male and female mice treated with a demyelinating agent, the authors found significant sex differences in myelin loss in which females exhibited more severe demyelination and motor deficits.

[Cell] Researchers adapted retrograde tracing using rabies viruses to investigate and manipulate neuron-tumor networks.

[Umeå Biotech Incubator] Four standout pharmaceutical pilot projects, chosen for their scientific excellence and innovative potential, will play a pivotal role in advancing BRIDGE Sweden.