Keep Current with the Latest in Cell Biology Research

An mTurq2-Col4a1 Mouse Model Allows for Live Visualization of Mammalian Basement Membrane Development

[Journal Of Cell Biology] Using an innovative planar-sagittal live imaging technique to visualize the basement membrane of developing skin, researchers directly observed basement membrane deformation during hair follicle budding and basal progenitor cell divisions.

The Role of APOBEC3B in Lung Tumor Evolution and Targeted Cancer Therapy Resistance

[Nature Genetics] Scientists studied the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B on epidermal growth factor receptor-driven lung cancer.

Ang-(1–7)/Mas Axis Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice via Restoration of Nox4-Nrf2 Redox Homeostasis

[European Journal Of Pharmacology] The angiotensin (Ang)-(1–7)-/Mas axis inhibited TGF-β1-induced lung fibroblast differentiation, inflammation, and fibrosis in bleomycin-treated lung tissue.

YAP1 Recognizes Inflammatory and Mechanical Cues to Exacerbate Benign Prostatic Hyperplasia via Promoting Cell Survival and Fibrosis

[Advanced Science] The correlation between YAP1 expression and fibrosis in human and rat benign prostatic hyperplasia specimens was analyzed, and the effects of YAP1 activation on prostatic cell survival and fibrosis, as well as the underlying mechanism, were also studied.

Prostate Lineage-Specific Metabolism Governs Luminal Differentiation and Response to Antiandrogen Treatment

[Nature Cell Biology] The authors developed an approach to perform metabolomics on primary prostate epithelial cells, and using this approach, discovered that the basal and luminal cells of the prostate exhibited distinct metabolomes and nutrient utilization patterns.

Mendelian Randomization Analyses Suggest a Causal Role for Circulating GIP and IL-1RA Levels in Homeostatic Model Assessment-Derived Measures of β-Cell Function and Insulin Sensitivity...

[Genome Medicine] Researchers evaluated associations between 11 circulating cytokines and hormones with T2D among a population of sub-Saharan Africans and tested for causal relationships using Mendelian randomization analyses.

Genetic Risk Converges on Regulatory Networks Mediating Early Type 2 Diabetes

[Nature] To identify early disease-driving events, researchers performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors.

Beta-Cell Intrinsic Dynamics Rather Than Gap Junction Structure Dictates Subpopulations in the Islet Functional Network

[eLife] Researchers used experimental and computational techniques to investigate the relationship between functional networks, structural networks, and intrinsic -cell dynamics in slow and fast oscillating islets.

Baker Centre for Pancreatic Cancer Helps Integrate Innovative Research With Patient Care at LHSC

[London Health Sciences Centre] The Baker Centre for Pancreatic Cancer at London Health Sciences Centre (LHSC) opened in 2019 as part of the vision of Rick and Shelley Baker. They generously donated $1.5 million to support pancreatic cancer care and research in the London region after Rick was diagnosed with pancreatic cancer.

Grad Students With Type 1 Diabetes Aim To Build a Better Future As Researchers, Advocates and Mentors

[University of Alberta] PhD student Jasmine Maghera, who was diagnosed with T1D when she was 11, remembers being told that five years from her diagnosis she wouldn’t need to take insulin anymore: technology would make injecting insulin obsolete. Now Maghera’s goal is to create and share that technology — if not for herself, for future generations.

Disrupted Hypothalamic Transcriptomics and Proteomics in a Mouse Model of Type 2 Diabetes Exposed to Recurrent Hypoglycaemia

[Diabetologia] Scientists identified the changes in hypothalamic gene and protein expression that underlie impaired counterregulatory response (CRR) in a mouse model of defective CRR.

Hypoblast From Human Pluripotent Stem Cells Regulates Epiblast Development

[Nature] The authors reported genetic and non-genetic approaches to generate authentic hypoblast cellsfrom naïve human PSCs.

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