[Journal of Experimental & Clinical Cancer Research] Researchers investigated the role of triggering receptor expressed on myeloid cells 2 (TREM2+) macrophages in various mouse HCC models. They investigated the role of TREM2+ macrophages in promoting the malignant phenotypes of HCC cells.

[Frontiers In Oncology] The authors discuss the dual role mitophagy plays in AML survival, the importance of targeting mitophagy to treat AML, and current progress in the area.

[Blood] Scientists established FLT3 as an ideal therapeutic target where ITD+ leukemic stem cells were eradicated upon FLT3 deletion, while HSCs were spared.

[Rigel Pharmaceuticals, Inc.] Rigel Pharmaceuticals, Inc. announced the first patient has been enrolled in a Phase 1 study evaluating the safety and tolerability of escalating doses of fostamatinib, the company's oral spleen tyrosine kinase inhibitor, in patients with sickle cell disease.

[Hepatology] Researchers established a Hepatitis B virus (HBV)-based-reporter gene expression system that mimicked HBV replication from transcription to virus egress. They screened 1,827 FDA-approved compounds and identified glycogen synthase kinase 3alpha/beta inhibitors as anti-HBV compounds.

[Journal of Clinical Investigation] The authors identified three young individuals from a consanguineous family presenting with inherited severe bone marrow failure syndromes characterized by profound anemia, thrombocytopenia, and neutropenia.

[Proceedings of The National Academy of Sciences of The United States of America] Researchers uncovered an intercellular mRNA transfer phenomenon that allowed for the adaptation and reprogramming of human primed pluripotent stem cells (hPSCs). This process was induced by the direct cell contact-mediated coculture with mouse ESCs under the condition impermissible for primed hPSC culture.

[Arteriosclerosis Thrombosis and Vascular Biology] Researchers described a novel in vitro model system that utilized endogenous ECM to study how modifications associated with age and metabolic disease impact the vascular smooth muscle cells phenotype.

[Cell Regeneration] Scientists introduced a human embryonic stem cell (hESC) culture system that facilitated the long-term, genetically stable expansion of hESCs, enabling cells to consistently sustain high levels of pluripotency markers, including NANOG, SOX2, TRA-1–60, and SSEA4, across extended periods.

[EmergentMedTech (PRNewswire)] EmergentMedTech announced its merger with TRU Biologix, a step in expanding its portfolio of biologics and advancing the field of regenerative medicine.

[Nature Genetics] To identify novel modifiers of somatic expansion, the authors used CRISPR–Cas9 editing in Huntington’s disease knock-in mice to enable in vivo screening of expansion-modifier candidates at scale.

[Science Advances] To improve the selectivity of the CAR T cell, scientists engineered a synthetic Notch receptor that selectively expressed the CAR upon binding to P-selectin, a cell adhesion protein overexpressed in tumor neovasculature.