[Small] Ellagic acid inhibited stemness maintenance by suppressing the hedgehog pathway, while Cu2+ further decreased stemness features of tumor cells by disrupting mitochondrial metabolism, effectively enhancing doxorubicin-mediated chemotherapy.

[Translational Oncology] Researchers determined the phenotypic and therapeutic relevance of tumor microenvironment in neurofibroma type I (NF1) patients. Tumor stem cell from NF1 were isolated and cultured using fluorescence activated cell sorting and colony formation experiments.

[Cancer Gene Therapy] Loss- and gain-of-function experiments were utilized to assess the biological effects of METTL3 and SOCS3 on the proliferation and stemness phenotypes in vitro and in vivo.

[Science Advances] Investigators developed a stem cell factor SOX9-based reporter for isolating CSCs in primary tumors and metastases of spontaneous mammary tumor models.

[Molecular Therapy - Nucleic Acids] Scientists explored novel miRNA–mRNA regulatory mechanisms that contribute to osimertinib resistance in lung cancer. They found that miR-204 expression in osimertinib-resistant lung cancer cells was markedly reduced compared to that in osimertinib-sensitive parental cells.

[Journal Of Cell Biology] Using an innovative planar-sagittal live imaging technique to visualize the basement membrane of developing skin, researchers directly observed basement membrane deformation during hair follicle budding and basal progenitor cell divisions.

[Nature Genetics] Scientists studied the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B on epidermal growth factor receptor-driven lung cancer.

[European Journal Of Pharmacology] The angiotensin (Ang)-(1–7)-/Mas axis inhibited TGF-β1-induced lung fibroblast differentiation, inflammation, and fibrosis in bleomycin-treated lung tissue.

[Advanced Science] The correlation between YAP1 expression and fibrosis in human and rat benign prostatic hyperplasia specimens was analyzed, and the effects of YAP1 activation on prostatic cell survival and fibrosis, as well as the underlying mechanism, were also studied.

[Nature Cell Biology] The authors developed an approach to perform metabolomics on primary prostate epithelial cells, and using this approach, discovered that the basal and luminal cells of the prostate exhibited distinct metabolomes and nutrient utilization patterns.

[Genome Medicine] Researchers evaluated associations between 11 circulating cytokines and hormones with T2D among a population of sub-Saharan Africans and tested for causal relationships using Mendelian randomization analyses.

[Nature] To identify early disease-driving events, researchers performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors.