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Pancreatic Cell News Volume 13.38 | Sep 27 2022

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Graphdiyne Oxide Nanosheets Display Selective Anti-Leukemia Efficacy Against DNMT3A-Mutant AML Cells

[Nature Communications] Scientists demonstrated that cell adhesion-related genes were predominantly enriched in DNMT3A-mutant AML cells and identify that graphdiyne oxide displayed an anti-leukemia effect specifically against these mutated cells.

Sleep Exerts Lasting Effects on Hematopoietic Stem Cell Function and Diversity

[Journal of Experimental Medicine] Researchers showed that sleep interruption restructures the epigenome of hematopoietic stem and progenitor cells and increased their proliferation, thus reducing hematopoietic clonal diversity through accelerated genetic drift.

Splenic Red Pulp Macrophages Provide a Niche for CML Stem Cells and Induce Therapy Resistance

[Leukemia] Investigators demonstrated that leukemia stem cells preferentially accumulated in the spleen and contribute to disease progression.

ABAT Gene Expression Associated with the Sensitivity of Hypomethylating Agents in Myelodysplastic Syndrome Through CXCR4/mTOR Signaling

[Cell Death Discovery] It was found that ABAT gene interference increased the sensitivity of HL-60 and THP-1 cells to HMAs treatment, while ABAT overexpression decreased its sensitivity.

Genetically Modified CD7-Targeting Allogeneic CAR-T Cell Therapy With Enhanced Efficacy for Relapsed/Refractory CD7-Positive Hematological Malignancies: A Phase I Clinical Study

[Cell Research] The authors developed healthy donor-derived, CD7-targeting CAR-T cells with genetic modifications to resist fratricide, graft-veruss-host disease and allogeneic rejection, as well as to potentiate antitumor function.

Allogeneic Hematopoietic Cell Transplantation in Patients with Juvenile Myelomonocytic Leukemia in Korea: A Report of the Korean Pediatric Hematology-Oncology Group

[Bone Marrow Transplantation] This multicenter study evaluated the characteristics, outcomes, and prognostic factors of allogeneic hematopoietic cell transplantation (HCT) in recipients with JMML who were diagnosed between 2000 and 2019 in Korea.

Protein Arginine Methyltransferase 1 in the Generation of Immune Megakaryocytes: A Perspective Review

[Journal of Biological Chemistry] Advances in single-cell RNA sequencing analysis from several studies have revealed that bone marrow Megakaryocytess are heterogeneous and can be clustered into three–four subpopulations: a subgroup that is adjacent to the hematopoietic stem cells, a subgroup expressing genes for platelet biogenesis, and a subgroup expressing immune-responsive genes.

Platelet–Acute Leukemia Interactions

[Clinica Chimica Acta] The authors discusses the changes occurring in platelet count, mean platelet volume, platelet distribution width, reticulated platelets, platelet membrane glycoprotein, platelet aggregation, and activation in acute leukemia patients.

ExPath Grad Student Madeline Mayday Awarded Grant from the NIDDK Cooperative Centers of Excellence in Hematology

[Yale School of Medicine] Madeline Mayday a fourth-year Experimental Pathology graduate student was recently awarded a 2022 National Institute of Diabetes and Digestive and Kidney Diseases Hematology Centers Program Type B Pilot and Feasibility grant for her project entitled, “Investigation of RBM15 and the m6A Epitranscriptome in Megakaryopoiesis.”

Intratumor Heterogeneity and T Cell Exhaustion in Primary CNS Lymphoma

[Genome Medicine] The authors performed flow cytometry, single-cell RNA sequencing, and B cell receptor sequencing of primary central nervous system lymphoma cells released from biopsy material, blood, and cerebrospinal fluid, and spatial transcriptomics of biopsy samples.

CNS Myelination Requires VAMP2/3-Mediated Membrane Expansion in Oligodendrocytes

[Nature Communications] Through live imaging, the authors discovered that VAMP2/3-mediated exocytosis drives membrane expansion within myelin sheaths to initiate wrapping and power sheath elongation.

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