Keep Current with the Latest in Cell Biology Research

The Physiological Role of β-Cell Heterogeneity in Pancreatic Islet Function

The focus of this Review is the description of how endocrine cell heterogeneity affects the regulation of hormone secretion within the islets of Langerhans.
[Nature Reviews Endocrinology]
[zotpress userid=” items=’ARAWWK93′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Copine 3 “CPNE3” Is a Novel Regulator for Insulin Secretion and Glucose Uptake in Pancreatic β-Cells

Copine 3 (CPNE3) is a calcium-dependent phospholipid-binding protein that has been found to play an essential role in cancer progression and stages. RNA sequencing and microarray data revealed that CPNE3 was highly expressed in human islets compared to other CPNE genes.
[Scientific Reports]
[zotpress userid=” items=’ARAWWK95′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Human Islet T Cells Are Highly Reactive to Preproinsulin in Type 1 Diabetes

Scientists comprehensively examined preproinsulin specificity of CD8 T cells obtained from pancreatic islets of organ donors with and without type 1 diabetes (T1D) and identified epitopes throughout the entire preproinsulin protein and defective ribosomal products derived from preproinsulin messenger RNA.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=” items=’ARAWWK96′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Marker-Free Lineage Tracing Reveals an Environment-Instructed Clonogenic Hierarchy in Pancreatic Cancer

Researchers used marker-independent stochastic clonal labeling, combined with quantitative modeling of tumor expansion, to uncover pancreatic ductal adenocarcinoma tissue growth dynamics.
[Cell Reports]
[zotpress userid=” items=’ARAWWK97′ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Epithelial Memory of Inflammation Limits Tissue Damage While Promoting Pancreatic Tumorigenesis

By investigating the effects of inflammation on normal pancreatic epithelial cells in different mouse models, scientists discovered that long after the complete resolution, a transient inflammatory event primed pancreatic epithelial cells to cooperate with oncogenic Kras to induce pancreatic tumors.
[Science]
[zotpress userid=” items=’ARAWWK98′ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

The Healthy Exocrine Pancreas Contains Preproinsulin-Specific CD8 T Cells That Attack Islets in Type 1 Diabetes

The authors quantified preproinsulin-specific CD8+ T cells within different areas of the human pancreas from nondiabetic controls, autoantibody-positive donors, and donors with type 1 diabetes to investigate their role in diabetes development.
[Science Advances]
[zotpress userid=” items=’ARAWWK99′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

MK8722, an AMPK Activator, Inhibiting Carcinoma Proliferation, Invasion and Migration in Human Pancreatic Cancer Cells

MK8722 is a potent and systemic pan-AMPK activator. It is an effective, direct, allosteric activator of AMPK complex in many mammals. Scientists investigated the anti-pancreatic cancer cells effects of MK8722 on two different human pancreatic cancer cell lines.
[Biomedicine & Pharmacotherapy]
[zotpress userid=” items=’ARAWWK100′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Transcriptome and Proteome Analysis of the Antitumor Activity of Maslinic Acid against Pancreatic Cancer Cells

Maslinic acid (MA) is a triterpenoid compound of natural abundance in olive plants possessing numerous biological activities. Researchers explored the anti-tumor activity of MA on human pancreatic cancer cells and the potential underlying molecular mechanism.
[Aging]
[zotpress userid=” items=’ARAWWK101′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Identification of Protease Serine S1 Family Member 53 as a Mitochondrial Protein in Murine Islet Beta Cells

Scientists identified genes that were specifically expressed in pancreatic islet β-cells. Large-scale complementary DNA-sequencing analysis was performed for 3,429 expressed sequence tags derived from murine MIN6 β-cells, through homology comparisons using the GenBank database.
[Islets]
[zotpress userid=” items=’ARAWWK102′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Better Therapeutics Enrolls First Patient in Real-World Evidence Study with Catalyst Health Network Evaluating BT-001, a Prescription Digital Therapeutic for Type 2 Diabetes

Better Therapeutics, Inc. announced the first patient has been enrolled in a real-world evidence study to evaluate the long-term effectiveness and healthcare utilization changes associated with the use of BT-001 for the treatment of type 2 diabetes.
[Better Therapeutics, Inc.]
[zotpress userid=” items=’ARAWWK103′ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Neurotoxins Subvert the Allosteric Activation Mechanism of SARM1 to Induce Neuronal Loss

Investigators showed the nicotinamide analog 3-acetylpyridine, was converted to 3-APMN, which activated SARM1 and induced SARM1-dependent NAD+ depletion, axon degeneration, and neuronal death.
[Cell Reports]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share