Keep Current with the Latest in Cell Biology Research
The focus of this Review is the description of how endocrine cell heterogeneity affects the regulation of hormone secretion within the islets of Langerhans.
[Nature Reviews Endocrinology]
[zotpress userid=” items=’ARAWWK93′ style=’apa’ cite=’yes’]
Copine 3 (CPNE3) is a calcium-dependent phospholipid-binding protein that has been found to play an essential role in cancer progression and stages. RNA sequencing and microarray data revealed that CPNE3 was highly expressed in human islets compared to other CPNE genes.
[zotpress userid=” items=’ARAWWK95′ style=’apa’ cite=’yes’]
Scientists comprehensively examined preproinsulin specificity of CD8 T cells obtained from pancreatic islets of organ donors with and without type 1 diabetes (T1D) and identified epitopes throughout the entire preproinsulin protein and defective ribosomal products derived from preproinsulin messenger RNA.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=” items=’ARAWWK96′ style=’apa’ cite=’yes’]
Researchers used marker-independent stochastic clonal labeling, combined with quantitative modeling of tumor expansion, to uncover pancreatic ductal adenocarcinoma tissue growth dynamics.
[zotpress userid=” items=’ARAWWK97′ style=’apa’ cite=’yes’]
By investigating the effects of inflammation on normal pancreatic epithelial cells in different mouse models, scientists discovered that long after the complete resolution, a transient inflammatory event primed pancreatic epithelial cells to cooperate with oncogenic Kras to induce pancreatic tumors.
[zotpress userid=” items=’ARAWWK98′ style=’apa’ cite=’yes’]
The authors quantified preproinsulin-specific CD8+ T cells within different areas of the human pancreas from nondiabetic controls, autoantibody-positive donors, and donors with type 1 diabetes to investigate their role in diabetes development.
[zotpress userid=” items=’ARAWWK99′ style=’apa’ cite=’yes’]
MK8722 is a potent and systemic pan-AMPK activator. It is an effective, direct, allosteric activator of AMPK complex in many mammals. Scientists investigated the anti-pancreatic cancer cells effects of MK8722 on two different human pancreatic cancer cell lines.
[Biomedicine & Pharmacotherapy]
[zotpress userid=” items=’ARAWWK100′ style=’apa’ cite=’yes’]
Maslinic acid (MA) is a triterpenoid compound of natural abundance in olive plants possessing numerous biological activities. Researchers explored the anti-tumor activity of MA on human pancreatic cancer cells and the potential underlying molecular mechanism.
[zotpress userid=” items=’ARAWWK101′ style=’apa’ cite=’yes’]
Scientists identified genes that were specifically expressed in pancreatic islet β-cells. Large-scale complementary DNA-sequencing analysis was performed for 3,429 expressed sequence tags derived from murine MIN6 β-cells, through homology comparisons using the GenBank database.
[zotpress userid=” items=’ARAWWK102′ style=’apa’ cite=’yes’]
Better Therapeutics, Inc. announced the first patient has been enrolled in a real-world evidence study to evaluate the long-term effectiveness and healthcare utilization changes associated with the use of BT-001 for the treatment of type 2 diabetes.
[Better Therapeutics, Inc.]
[zotpress userid=” items=’ARAWWK103′ style=’apa’ cite=’yes’]
Investigators showed the nicotinamide analog 3-acetylpyridine, was converted to 3-APMN, which activated SARM1 and induced SARM1-dependent NAD+ depletion, axon degeneration, and neuronal death.
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]