Keep Current with the Latest in Cell Biology Research

Clinical Implications of Wnt Pathway Genetic Alterations in Men with Advanced Prostate Cancer

[Prostate Cancer and Prostatic Diseases] Investigators utilized the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort clinical-genomic database for this retrospective analysis.

Targeting Valine Catabolism to Inhibit Metabolic Reprogramming in Prostate Cancer

[Cell Death & Disease] Through the suppression of branched-chain amino acid (BCAA) availability, researchers reported significantly reduced lipid content, strongly indicating that BCAAs were important lipogenic fuels in prostate cancer.

Embryonic Microenvironment Suppresses YY1 and YY1-Related Genes in Prostate Cancer Stem Cells

[Pathology - Research and Practice] To investigate the embryonic microenvironment impact on Yin yang 1 (YY1) expression in CSC populations, firstly cancer stem cells (CSCs) were microinjected into the inner cell mass of blastocysts and then prostate CSCs were co-cultured with blastocysts.

A Novel Prognostic Model of De Novo Metastatic Hormone-Sensitive Prostate Cancer to Optimize Treatment Intensity

[International Journal of Clinical Oncology] 1092 Japanese patients diagnosed with de novo metastatic hormone-sensitive prostate cancer between 2014 and 2020 were registered. The patients treated with androgen deprivation therapy and first-generation anti-androgens were assigned to the discovery or validation cohorts.

The PP2A Regulator IER5L Supports Prostate Cancer Progression

[Cell Death & Disease] The authors showed that the less studied member of the Immediate Early Response (IER) family, IER 5 like (IER5L), was upregulated in aggressive prostate cancer.

Dr. Tanya Stoyanova Receives $1.8 Million to Reveal New Treatment Strategies for Advanced Prostate Cancer

[UCLA Health] Dr. Tanya Stoyanova was awarded a $1.8 million grant from the National Cancer Institute to identify new drivers and test new therapeutic strategies for advanced treatment-resistant prostate cancer.

China–US Research Collaborations Are in Decline — This Is Bad News for Everyone

[Nature] Scientists have been warning that political tensions between China and the United States, combined with the pandemic, have affected research collaborations between the two countries.

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

[Cancer Research] Disruption of cholesterol homeostasis with pitavastatin synergized with AKT inhibition to induce triple-negative breast cancer (TNBC) cytotoxicity in vitro, in mouse TNBC xenografts and in patient-derived, estrogen receptor-negative breast cancer organoids.

Cryopreservation of Human Kidney Organoids

[Cellular and Molecular Life Sciences] Scientists evaluated cryopreservation strategies for kidney organoids by contrasting slow-freezing and vitrification methods. 118 kidney organoids were categorized into five conditions.

Emergence of Large-Scale Cell Death through Ferroptotic Trigger Waves

[Nature] The authors demonstrated that ferroptosis, an iron- and lipid-peroxidation-dependent form of cell death, could propagate across human cells over long distances at constant speeds through trigger waves of reactive oxygen species.

Selective Pressures of Platinum Compounds Shape the Evolution of Therapy-Related Myeloid Neoplasms

[Nature Communications] Researchers used single-cell whole genome sequencing and phylogenetic inference to show that the founding cell of therapy-related myeloid neoplasms in children started expanding after cessation of platinum exposure.

Vasohibin Inhibition Improves Myocardial Relaxation in a Rat Model of Heart Failure with Preserved Ejection Fraction

[Science Translational Medicine] Scientists explored whether increased microtubule network (MTN) detyrosination contributed to impaired diastolic function in the ZSF1 obese rat model of Heart failure with preserved ejection fraction (HFpEF) and designed a small-molecule vasohibin inhibitor to ablate MTN detyrosination in vivo.

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