Keep Current with the Latest in Cell Biology Research

Telomere Shortening Induces Aging-Associated Phenotypes in hiPSC-Derived Neurons and Astrocytes

[Biogerontology] Investigators explored the possibility of inducing aging-associated features in cell types of the central nervous system using hiPSC technology.

Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma

[Journal Of Neuroscience] The authors reported using human tumor specimens and primary spheroids from male and female patients that GlialCAM, was differentially expressed in subpopulations of glioblastoma cells.

Germline PTEN Genotype-Dependent Phenotypic Divergence During the Early Neural Developmental Process of Forebrain Organoids

[Molecular Psychiatry] Investigators showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.

Functional Brain Region-Specific Neural Spheroids for Modeling Neurological Diseases and Therapeutics Screening

[Communications Biology] Scientists described a method for generating functional neural spheroids by cell-aggregation of differentiated human iPSC-derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain.

INPP5D Regulates Inflammasome Activation in Human Microglia

[Nature Communications] Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, the authors found that reduction in INPP5D activity was associated with molecular profiles consistent with disrupted autophagy and inflammasome activation.

CerS6-Dependent Ceramide Synthesis in Hypothalamic Neurons Promotes ER/Mitochondrial Stress and Impairs Glucose Homeostasis in Obese Mice

[Nature Communications] Scientists found increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neurons exposed to palmitate in vitro and in the hypothalamus of obese mice.

Analysis of BRCA1- and BRCA2-Related Pancreatic Cancer and Survival

[Jama Network Open] This study included 234 consecutively identified patients with germline BRCA PVs and a diagnosis of PDAC. Of patients with BRCA1, 33 of 69 were males with a median age of 63 years. Of patients with BRCA2, 84 of 165 were males, and the median age was 64 years.

Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells

[Diabetes] Investigators discuss conflicting views of the relationship between pancreatic α-cells and β-cells and seek to understand how communication depends on blood flow and/or paracrine mechanisms.

C1QA and COMP: Plasma-Based Biomarkers for Early Diagnosis of Pancreatic Neuroendocrine Tumors

[Scientific Reports] The authors utilized proteomics as a valuable approach for cancer biomarker discovery; therefore, mass spectrometry-based proteomic profiling was conducted on plasma samples from 12 subjects to identify potential proteins capable of effectively distinguishing PanNET from healthy controls.

Banked Term Umbilical Cord Blood to Meet the Packed Red Blood Cell Transfusion Needs of Extremely-Low-Gestational-Age Neonates: A Feasibility Analysis

[Journal Of Perinatology] Researchers retrospectively analyzed all ELGANs RBC Tx over the past three years, estimated local cord blood availability, and assesed interest in this project, and implementation barriers, through stakeholder surveys.

Placental Streptococcus agalactiae DNA Is Associated with Neonatal Unit Admission and Fetal Pro-Inflammatory Cytokines in Term Infants

[Nature Microbiology] The authors re-analyzed a dataset which detected Streptococcus agalactiae DNA in the placenta in ~5% of women before the onset of labour as a case control study of neonatal unit admission.

Stem Cell-Based Interventions for the Treatment of Stroke in Newborn Infants

[Cochrane Database Of Systematic Reviews] To evaluate the benefits and harms of stem cell‐based interventions for the treatment of stroke in newborn infants compared to control or stem‐cell based interventions of a different type or source.

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