Keep Current with the Latest in Cell Biology Research

TMEM16E Regulates Endothelial Cell Procoagulant Activity and Thrombosis

[Journal Of Clinical Investigation] Researchers employed a focused genetic screen to evaluate the contribution of transmembrane phospholipid transport on endothelial cell (EC) procoagulant activity. They identified two TMEM16 family members, TMEM16F and TMEM16E, which were both required to support coagulation on ECs via phosphatidylserine externalization.

Fabrication of CO-releasing Surface to Enhance the Blood Compatibility and Endothelialization of TiO2 Nanotubes on Titanium Surface

[Biomaterials Advances] The regular titanium dioxide (TiO2) nanotube arrays were firstly prepared in situ on the titanium surface by anodic oxidation, followed by the immobilization of the complex of sodium alginate/carboxymethyl chitosan on the self-assembled modified nanotube surface.

Breast Tumors Interfere with Endothelial TRAIL at the Premetastatic Niche to Promote Cancer Cell Seeding

[Science Advances] Investigators found that endothelial cells at the premetastatic niche coexpress tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5.

Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)–Dependent Vasodilation and Blood Pressure Homeostasis

[Arteriosclerosis Thrombosis And Vascular Biology] Isolated mouse mesenteric artery and endothelial cell models were used to determine S1P-induced vasodilation, intracellular calcium, membrane potentials, and calcium-activated potassium channels, KCa3.1 and KCa2.3.

Preferential Hematopoietic Differentiation in Induced Pluripotent Stem Cells Derived from Human Umbilical Cord Arterial Endothelial Cells

[Arteriosclerosis Thrombosis And Vascular Biology] Human induced pluripotent stem cells (hiPSCs) were generated from somatic cells by transduction of 4 human transcription factors using Sendai virus vectors. Genome-wide DNA methylation analysis and transcriptional analysis were performed to evaluate the pluripotent capacity and somatic memory state of hiPSCs.

Hedgehog-Induced ZFYVE21 Promotes Chronic Vascular Inflammation by Activating NLRP3 Inflammasomes in T Cells

[Science Signaling] Using humanized mouse models, primary human cells, and patient samples, scientists identified a T cell–autonomous role for the zinc finger protein ZFYVE21 in promoting chronic vascular inflammation associated with allograft vasculopathy.

Temporally and Regionally Distinct Morphogenetic Processes Govern Zebrafish Caudal Fin Blood Vessel Network Expansion

[Development] The authors performed a longitudinal analysis of zebrafish caudal fin vascular assembly, revealing the existence of temporally and spatially distinct morphogenetic processes.

Endothelial Cell Vasodilator Dysfunction Mediates Progressive Pregnancy-Induced Hypertension in Endothelial Cell Tetrahydrobiopterin Deficient Mice

[Vascular Pharmacology] The vascular reactivity of mouse aortas and uterine arteries from non-pregnant and pregnant endothelial cell-specific tetrahydrobiopterin deficient mice was assessed by wire myography. Systolic blood pressure was assessed by tail cuff plethysmography.

A Novel Role for YPEL2 in Mediating Endothelial Cellular Senescence via the p53/p21 Pathway

[Mechanisms of Ageing and Development] Investigators reported the essential role of yippee-like 2 (YPEL2) in promoting senescence in human umbilical vein endothelial cells and the upregulation of YPEL2 in human atherosclerotic plaques.

Baicalin Inhibited Both the Furin/TGFβ1/Smad3/TSP-1 Pathway in Endothelial Cells and the AKT/Ca2+/ROS Pathway in Platelets to Ameliorate Inflammatory Coagulopathy

[European Journal of Pharmacology] The effects of baicalin, an active component of the traditional Chinese medicine Huangqin, on inflammatory coagulopathy were observed both in vivo and in vitro.

N-Acetyl-L-Cysteine Attenuates Oxidative Stress-Induced Bone Marrow Endothelial Cells Apoptosis by Inhibiting BAX/Caspase 3 Pathway

[Biochemical and Biophysical Research Communications] Researchers explored injury caused by oxidative stress enhancement in bone marrow endothelial cells (BMECs) both in vivo and in vitro. The BMECs, indicators of oxidative stress, bone mass, and apoptosis-related proteins were analyzed in different age groups.

The Vascular Endothelial Growth Factor (VEGF) System as a Key Regulator of Ovarian Follicle Angiogenesis and Growth

[Molecular Reproduction and Development] The members of the VEGF system affect the proliferation, survival, and migration of endothelial and nonendothelial cells and are involved in the regulation of follicular angiogenesis and development.

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