Keep Current with the Latest in Cell Biology Research
Organoid Modeling of Human Fetal Lung Alveolar Development Reveals Mechanisms of Cell Fate Patterning and Neonatal Respiratory Disease
[Cell Stem Cell] Researchers identified an alveolar-fated epithelial progenitor in human fetal lungs, which they grew as self-organizing organoids that modeled key aspects of cell lineage commitment.
[Nature Communications] Using computational tools, organoids, and spatial tools, the authors showed that LY6D+ basosquamous cells represented a persister population lying on a central node along the skin lineage-associated spectrum of epithelial states.
Epithelial TGFβ Engages Growth-Factor Signaling to Circumvent Apoptosis and Drive Intestinal Tumorigenesis with Aggressive Features
[Nature Communications] Scientists identified a cohort of early-stage colorectal tumors, with aggressive features and a propensity to disseminate early, that were characterized by high epithelial cell-intrinsic TGFβ signaling.
The Chromatin Remodeler CHD6 Promotes Colorectal Cancer Development by Regulating TMEM65-Mediated Mitochondrial Dynamics via EGF and Wnt Signaling
[Cell Discovery] The authors reported that CHD6 was highly expressed in colorectal cancer, and that CHD6 knockdown inhibited cancer cell proliferation, migration, invasion, and tumorigenesis.
Ex Vivo Chemosensitivity Assay Using Primary Ovarian Cancer Organoids for Predicting Clinical Response and Screening Effective Drugs
[Human Cell] We prepared organoids using the cancer tissue-originated spheroid method from 61 patients with ovarian cancer. Chemosensitivity assays for paclitaxel and carboplatin were performed using the primary organoids from 50 patients who received the chemotherapy.
[iScience] The authors summarize the recent progress of novel approaches to engineering oral and maxillofacial organoids. They introduce the necessary components and their roles in forming oral and maxillofacial organoids.
[Molecular Psychiatry] Scientists review the current methods used to generate microglia-containing human brain organoids (MC-HBOs) and provide opinions on the use of MC-HBOs for disease modeling and functional studies.
Crown Bioscience and ERS Genomics Announce Global CRISPR/Cas9 Licensing Agreement for Genome Editing Patents
[ERS Genomics Limited] Crown Bioscience, Inc. and ERS Genomics Ltd. have signed a global license agreement for access to the foundational CRISPR/Cas9 patent portfolio held by ERS, which provides the company full license to operate globally using CRISPR/Cas9 for gene editing.
[Immunity] To gain insight into the process of mucosal healing, researchers longitudinally examined the immune cell composition during intestinal damage and regeneration.
Epithelial TGFβ Engages Growth-Factor Signaling to Circumvent Apoptosis and Drive Intestinal Tumourigenesis with Aggressive Features
[Nature Communications] Investigators identified a cohort of born to be bad early-stage colorectal tumours, with aggressive features and a propensity to disseminate early, that were characterized by high epithelial cell-intrinsic TGFβ signaling.
[Cellular and Molecular Gastroenterology and Hepatology] Researchers used transcriptomic analyses to dissect the role of HNF4α in the maintenance of jejunal epithelial culture when cultured ex vivo as enteroids, in the presence or absence of compensatory mesenchymal cells.
Bacterial Protein MakA Causes Suppression of Tumour Cell Proliferation via Inhibition of PIP5K1α/Akt Signaling
[Cell Death & Disease] The authors evaluated the effects of MakA on the host cell PIP5K1α lipid-signaling pathway and the mechanism by which MakA inhibited cell proliferation and induced cell cycle arrest, particularly in HCT8 colon cancer cells.