Keep Current with the Latest in Cell Biology Research

Dual Electrochemical Sensing of Spiked Virus and SARS-CoV-2 Using Natural Bed-Receptor (MV-gal1)

Investigators introduced a natural bed-receptor surface as Microparticle Vesicle-Galactins1 (MV-gal1) with the ability of glycan binding to screen every spiked virus.
[Scientific Reports]
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The Hepatic Stellate Cells (HSTCs) and Adipose-Derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications

Researchers suggested that inter-organ communication on the level of stem progenitor cells-HSTCs and ASCs could represents a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity.
[Stem Cell Reviews and Reports]
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Aadi Bioscience Announces FDA Approval of Its First Product FYARRO for Patients with Locally Advanced Unresectable or Metastatic Malignant Perivascular Epithelioid Cell Tumor (PEComa)

Aadi Bioscience, Inc. announced that the US FDA has approved FYARRO for intravenous use for the treatment of adult patients with locally advanced unresectable or metastatic malignant PEComa.
[Aadi Bioscience, Inc.]
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An Atlas of Protein Turnover Rates in Mouse Tissues

Using stable isotope labeling and mass spectrometry, research determine the in vivo turnover rates of thousands of proteins—including those of the extracellular matrix—in a set of biologically important mouse tissues.
[Nature Communications]
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Mammary Tumor Cells Remodel the Bone Marrow Vascular Microenvironment to Support Metastasis

Using breast cancer as a model of solid tumor metastasis to the bone marrow, we applied large-scale quantitative 3D imaging to characterize temporal changes in the bone marrow microenvironment during disease progression.
[Nature Communications]
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Sorafenib Attenuates Liver Fibrosis by Triggering Hepatic Stellate Cell Ferroptosis via HIF-1α/SLC7A11 Pathway

Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.
[Cell Proliferation]
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Multiple Stimuli-Responsive MXene-Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Investigators presented the development of a 2D MXene-based hydrogel system for highly efficient photo- and magnetic-responsive drug delivery oriented to deep chronic wounds repair.
[Small]
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Inhibition of Matrix Stiffness Relating Integrin β1 Signaling Pathway Inhibits Tumor Growth In Vitro and in Hepatocellular Cancer Xenografts

A higher matrix stiffness equipped tumor cells with enhanced stemness and proliferative characteristics, which was dependent on the activation of integrin β1/FAK/ERK1/2/NF-κB signaling pathway.
[BMC Cancer]
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Long Non-Coding RNA HOMER3-AS1 Drives Hepatocellular Carcinoma Progression via Modulating the Behaviors of Both Tumor Cells and Macrophages

The authors identified a lncRNA, HOMER3-AS1, which was over-expressed in hepatocellular carcinoma (HCC) and correlated with poor survival of HCC patients. HOMER3-AS1 promoted HCC cellular proliferation, migration, and invasion, and reduced HCC cellular apoptosis.
[Cell Death & Disease]
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Ligature Induced Periodontitis in Rats Causes Gut Dysbiosis Leading to Hepatic Injury through SCD1/AMPK Signaling Pathway

RNA sequencing of liver tissue showed that the expression of SCD1 increased significantly in chronic periodontitis rats compared to controls. KEGG enrichment analysis showed that the AMPK signalling pathway may have been involved in liver steatosis.
[Life Sciences]
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Concurrent Disruption of Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis

Investigators showed that an unanticipated severe tumor phenotype was contributed collectively by severe cholestasis, metabolic changes, upregulated cell cycle progression and disruption of circadian rhythm in mutant hepatocytes.
[Molecular Cancer Research]
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