Keep Current with the Latest in Cell Biology Research

A Single-Cell Atlas of the Normal and Malformed Human Brain Vasculature

Investigators profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity.
[Science]
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TIRAP Drives Myelosuppression through an Ifnγ–Hmgb1 Axis That Disrupts the Endothelial Niche in Mice

The authors showed that toll/interleukin-1 receptor domain containing adaptor protein (TIRAP) was overexpressed in various types of myelodysplastic syndromes and suppressed all three major hematopoietic lineages.
[Journal of Experimental Medicine]
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Chimeric Antigen Receptor Engineered T Cells and Their Application in the Immunotherapy of Solid Tumors

With several hundred clinical trials undergoing worldwide, the pace of CAR-T immunotherapy moves from bench to bedside is unprecedented.
[Expert Reviews in Molecular Medicine]
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Human Inhibitory Leukocyte Ig-Like Receptors: From Immunotolerance to Immunotherapy

The authors discuss the immunoregulatory functions of human LILRBs and the potential of targeting them to manipulate immune responses in various pathologies.
[JCI Insight]
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INmune Bio, Inc. Announces Research Collaboration with Chinese University of Hong Kong to Evaluate INKmune in Nasopharyngeal Cancer

INmune Bio, Inc. announced that the company has entered into a pre-clinical research collaboration with Chinese University of Hong Kong to evaluate INKmune™ in nasopharyngeal cancer, a type of head and neck cancer.
[INmune Bio, Inc.]
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Integrated Histopathological, Lipidomic, and Metabolomic Profiles Reveal Mink Is a Useful Animal Model to Mimic the Pathogenicity of Severe COVID-19 Patients

The authors demonstrated that minks were largely permissive to SARS-CoV-2, characterized by severe and diffuse alveolar damage, and lasted at least 14 days post inoculation.
[Signal Transduction and Targeted Therapy]
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Immune Imprinting, Breadth of Variant Recognition and Germinal Center Response in Human SARS-CoV-2 Infection and Vaccination

Scientists analyzed human lymph nodes after infection or mRNA vaccination for correlates of serological differences.
[Cell]
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Todos Medical and NLC Pharma Announce Primary and Secondary Endpoints Met in NLC-V-01 Phase II Clinical Trial of Oral Antiviral 3CL Protease Inhibitor Tollovir™ in the Treatment of Hospitalized COVID-19 Patients

Todos Medical, Ltd. announced positive interim data for its Tollovir™ oral antiviral 3CL protease inhibitor Phase II clinical trial for the treatment of hospitalized (severe and critical) COVID-19 patients.
[Todos Medical, Ltd.]
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Lung-Resident Memory B Cells Established after Pulmonary Influenza Infection Display Distinct Transcriptional and Phenotypic Profiles

Scientists characterized tissue-resident memory B cells that are stably maintained in the lungs of mice after pulmonary influenza infection.
[Science Immunology]
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Forskolin-Induced Organoid Swelling Is Associated with Long-Term CF Disease Progression

Individual cystic fibrosis transmembrane conductance regulator function was defined by FIS, measured as the relative size increase of intestinal organoids after stimulation with 0.8 µM forskolin, quantified as area under the curve.
[European Respiratory Journal]
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Kidney Organoids Recapitulate Human Basement Membrane Assembly in Health and Disease

Researchers investigated the dynamics of basement membranes assembly in human pluripotent stem cell-derived kidney organoids.
[eLife]
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