[Journal Of Cell Biology] Using an innovative planar-sagittal live imaging technique to visualize the basement membrane of developing skin, researchers directly observed basement membrane deformation during hair follicle budding and basal progenitor cell divisions.

[Nature Genetics] Scientists studied the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B on epidermal growth factor receptor-driven lung cancer.

[European Journal Of Pharmacology] The angiotensin (Ang)-(1–7)-/Mas axis inhibited TGF-β1-induced lung fibroblast differentiation, inflammation, and fibrosis in bleomycin-treated lung tissue.

[Advanced Science] The correlation between YAP1 expression and fibrosis in human and rat benign prostatic hyperplasia specimens was analyzed, and the effects of YAP1 activation on prostatic cell survival and fibrosis, as well as the underlying mechanism, were also studied.

[Nature Cell Biology] The authors developed an approach to perform metabolomics on primary prostate epithelial cells, and using this approach, discovered that the basal and luminal cells of the prostate exhibited distinct metabolomes and nutrient utilization patterns.

[Genome Medicine] Researchers evaluated associations between 11 circulating cytokines and hormones with T2D among a population of sub-Saharan Africans and tested for causal relationships using Mendelian randomization analyses.

[Nature] To identify early disease-driving events, researchers performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors.

[eLife] Researchers used experimental and computational techniques to investigate the relationship between functional networks, structural networks, and intrinsic -cell dynamics in slow and fast oscillating islets.

[London Health Sciences Centre] The Baker Centre for Pancreatic Cancer at London Health Sciences Centre (LHSC) opened in 2019 as part of the vision of Rick and Shelley Baker. They generously donated $1.5 million to support pancreatic cancer care and research in the London region after Rick was diagnosed with pancreatic cancer.

[University of Alberta] PhD student Jasmine Maghera, who was diagnosed with T1D when she was 11, remembers being told that five years from her diagnosis she wouldn’t need to take insulin anymore: technology would make injecting insulin obsolete. Now Maghera’s goal is to create and share that technology — if not for herself, for future generations.

[Diabetologia] Scientists identified the changes in hypothalamic gene and protein expression that underlie impaired counterregulatory response (CRR) in a mouse model of defective CRR.

[Nature] The authors reported genetic and non-genetic approaches to generate authentic hypoblast cellsfrom naïve human PSCs.