Keep Current with the Latest in Cell Biology Research

Neuroimmune Transcriptome Changes in Patient Brains of Psychiatric and Neurological Disorders

[Molecular Psychiatry] 1275 immune-related genes were curated and their expression changes investigated in 2467 postmortem brains of controls and patients with six major brain disorders, including schizophrenia, bipolar disorder, autism spectrum disorder, major depressive disorder, Alzheimer’s disease, and Parkinson’s disease.

Modular Automated Microfluidic Cell Culture Platform Reduces Glycolytic Stress in Cerebral Cortex Organoids

[Scientific Reports] Investigators developed a multiplex platform that automates the culture of individual organoids in isolated microenvironments at user-defined media flow rates.

CD147 Contributes to SARS-CoV-2-Induced Pulmonary Fibrosis

[Signal Transduction and Targeted Therapy] Investigators systemically analyzed lung pathogenesis in SARS-CoV-2- and its delta variant-infected humanized CD147 transgenic mice. Histopathology and Transmission Electron Microscopy revealed inflammation, fibroblast expansion and pronounced fibrotic remodeling in SARS-CoV-2-infected lungs.

Indictment of Monkey Importers Could Disrupt US Drug and Vaccine Research

[Science Insider] The US Department of Justice charged two Cambodian wildlife officials and several members of a Hong Kong-based primate supply company with illegally exporting hundreds—and potentially more than 2000— cynomolgus macaques, an endangered species, to the United States for research.

ZDHHC9 Promotes Colon Tumor Growth by Inhibiting Effector T Cells

[Oncology Letters] Using Gene Expression Profiling Interactive Analysis and Tumor Immune Estimation Resource, data obtained from The Cancer Genome Atlas were analyzed, and the results showed that ZDHHC9 was highly expressed in colon cancer and that patients with higher ZDHHC9 expression levels had a worse prognosis.

CTLA-4 on Thymic Epithelial Cells Complements Aire for T Cell Central Tolerance

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that a small population of medullary thymic epithelial cells expressed the coinhibitory receptor cytotoxic T lymphocyte-associated protein 4. These CTLA-4+ cells were detectable in perinates, peaked around young adulthood and expanded sixfold in the absence of Aire.

Eosinophils Protect against Pulmonary Hypertension through 14-HDHA and 17-HDHA

[European Respiratory Journal] Eosinophils infiltration and chemotaxis were investigated in peripheral blood and lung tissues from pulmonary arterial hypertension patients without allergic history and sugen/hypoxia-induced pulmonary hypertension mice.

Plasma Cell but Not CD20-Mediated B Cell Depletion Protects from Bleomycin-Induced Lung Fibrosis

[European Respiratory Journal] To determine the therapeutic potential of inhibiting B cell function in pulmonary fibrosis, scientists examined the effects of anti-CD20 B cell ablation therapy to selectively remove mature B-cells from the immune system and inhibit Blm-induced lung fibrosis.

Following Yale Investigator-Led Trials, FDA Approves First Drug to Delay Onset of Type 1 Diabetes

[Yale School of Medicine] The FDA approved teplizumab, the first drug with the ability to change the course of type 1 diabetes, or any autoimmune disease. Yale School of Medicine played a crucial role in the drug’s trials, most of which were led by Dr. Kevan Herold, Long Professor of Immunobiology and of Medicine

Advancements in the Characterization of Tissue Resident Memory T Cells in Skin Disease

[Clinical Immunology] The authors review the differentiation, regulation, variety and function of resident memory T cells and the roles they play in skin diseases, including cutaneous melanoma and psoriasis.

ARID2 Mitigates Hepatic Steatosis via Promoting the Ubiquitination of JAK2

[Cell Death & Differentiation] Scientists demonstrated that liver-specific loss of Arid2 induced hepatic steatosis and this progression could be exacerbated by a high-fat diet.

Branched-Chain Amino Acid Catabolism Breaks Glutamine Addiction to Sustain Hepatocellular Carcinoma Progression

[Cell Reports] Researchers demonstrated that branched-chain amino acid (BCAA) catabolism was activated in liver cancer cells without glutamine, leading to BCAA-derived carbon and nitrogen flow toward nucleotide synthesis.

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