[Current HIV/Aids Reports] The authors review the role of innate immune cells in shaping the viral reservoir and maintenance of long-term viral control of spontaneous Elite and Viremic HIV controllers.

[Dyadic International, Inc.] Dyadic International, Inc. announced that it has been awarded a $3 million grant from the Gates Foundation for the cell line development of monoclonal antibodies targeting respiratory syncytial virus (RSV) and malaria utilizing the company’s proprietary C1 protein production platform to provide globally accessible treatment options for underserved populations.

[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists characterized the biological signature of small cell lung cancer and outline the obstacles to current treatment, including impaired antigen presentation and T cell infiltration.

[Cancer and Metastasis Reviews] The authors review the clinical outcomes of CAR T cell therapy and the major resistance mechanisms that lead to poor outcomes. They also review the many innovative and encouraging strategies that are being developed to improve CAR T cell therapy for non-Hodgkin lymphomas.

[Stem Cell Research & Therapy] Researchers increased mitochondria transferred from bone marrow mesenchymal stem/stromal cells supported metabolic remodeling in leukemia stem cells to sustained their stemness.

[Naunyn-Schmiedebergs Archives of Pharmacology] Investigators elucidated the effects of pirfenidone, a FDA-approved oral anti-fibrotic drug which has recently shown antitumor potential, in the progression of TNBC and the underlying mechanisms.

[Breast Cancer Research] Scientists highlighted the potential role for NF-κB-associated factors, specifically lymphotoxin beta to be used as prognostic markers in TNBC, which could ultimately provide insight for improved targeted treatment approaches in the clinic.

[Scientific Reports] Through in vitro experiments with human immortalized keratinocytes (HaCat), researchers found that atorvastatin calcium could significantly reduce the ultraviolet radiation B-induced increased expression of age-related protein p16 and age-related gene p21, and also reduce the up-regulation of inflammatory factors such as IL-1 and IL-6.

[Cellular & Molecular Immunology] Investigators found that the level of peroxisome proliferator-activated receptor gamma was substantially reduced in the skin lesions of patients, and replicating this reduction in mice led to rapid disease onset with multiple hallmarks of systemic lupus erythematosus.

[Cell Death & Differentiation] Scientists identified that ubiquitin-specific protease 19 (USP19) was downregulated in pancreatic tumor tissues and forced expression of USP19 diminished tumorigenicity of pancreatic cancer.

[Experimental & Molecular Medicine] The authors revealed that glutamyl-prolyl-tRNA synthetase 1 (EPRS1) expression levels were increased in the fibrotic kidneys of patients and mice, especially in fibroblasts and proximal tubular epithelial cells, on the basis of single-cell analysis and immunostaining of fibrotic kidneys.

[Stem Cell Research & Therapy] Researchers presented a novel approach to highly and efficiently generate mature megakaryocytes and functional platelets from human ESCs (hESCs). The in vivo functionality of hESC-derived platelets closely resembled that of natural human platelets.