[Nature] Researchers identified dynamic cytoskeletal regulation of lymphatic endothelial cells shape, induced by isotropic stretch, as crucial for the integrity and function of dermal lymphatic capillaries.

[Communications Biology] Scientists uncovered that toll-like receptor 4 (TLR4) operated through multiple pathways in endothelial dysfunction: macrophage TLR4 mediated inflammatory damage to endothelial cells (ECs) and lymphatic ECs while endothelial TLR4 both directly sensitized cells to lipopolysaccharide-induced injury.

[Signal Transduction and Targeted Therapy] Using in vitro and orthotopic xenograft mouse models, scientists demonstrated that constitutively active mTORC1 signaling rendered PI3K inhibitor-resistant breast cancer exquisitely sensitive to various drugs targeting cancer metabolism.

[Nature Communications] Researchers reported that citronellal, a plant-derived acyclic monoterpene commonly used for personal care, stimulated skin renewal by promoting keratinocyte proliferation through the activation of transient receptor potential vanilloid 3 (TRPV3).

[Autophagy] Investigators demonstrated that truncated MCPyV-encoded large T-antigen (suppressed macroautophagy/autophagy by stabilizing and sequestering KIT in the paranuclear compartment via binding VPS39.

[Cell Death Discovery] Researchers presented a proof-of-concept PROTAC design tailored for glioblastoma (GBM) stem cells, potentially addressing the occurrence challenges for GBM.

[Scientific Reports] The authors demonstrated that PNO1 silencing markedly reduced the proliferation and invasion capabilities of ovarian cancer cell lines, triggering their apoptosis.

[Cell Communication and Signaling] By studying mouse bone marrow-derived macrophages, researchers showed that LY6E regulated IFN-α- and IC-induced production and secretion of mature interleukin-1β, foam cell formation, and several mitochondria-associated mechanisms.

[Cell Reports Medicine] Scientists showed that pro-inflammatory B-T cell-enriched cell clusters form during autoproliferation and mirror features of a germinal center reaction.

[Journal of Translational Medicine] The authors comprehensively review the regulatory mechanisms related to the functions of ncRNAs and the Wnt/β-catenin pathway in lung cancer.

[Cell Death & Disease] Investigators found that dynamic BH3 profiling presented an excellent predictive capacity to anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors, that would facilitate their use in a clinical setting and complementing the readout of standard diagnostic assays.

[Imbed Biosciences (BioSpace)] Imbed Biosciences announced the US FDA has approved an Investigational Device Exemption application to conduct a feasibility clinical trial to validate the safety of their pipeline polymeric matrix with silver and gallium ions in human donor site wounds.