[PLOS One] Using fluorescence-based immunohistological analyses of the colon from experimental mice, scientists demonstrated that along with contribution of goblet cells, mucin glycosylation involves deep crypt secretory cells, a specialized mucin-producing cell population in the colon.

[Cell & Bioscience] Researchers demonstrated that CREPT/RPRD1B, a protein highly expressed in tumors and essential for crypt-base columnar cell maintenance, was required for revival stem cell differentiation during intestinal regeneration.

[Firefly Neuroscience, Inc. (GlobeNewswire)] Firefly Neuroscience, Inc. highlighted its ongoing collaboration with Prof. Dr. med. Christian Schaaf on a groundbreaking study investigating the neurophysiological impact of 15q13.3 copy number variants.

[Nature Neuroscience] Investigators tested the hypothesis that pathological tau contributes to synapse loss and may spread through the brain by moving from presynapses to postsynapses.

[Nature Communications] Scientists explored the expression dynamics of cortical and neuropsychiatric disorder-associated genes in datasets generated from human NSCs across telencephalic fate transitions in vitro and in vivo.

[Journal of Experimental Medicine] The authors generated a postnatal inducible whole-body Ngly1 knockout mouse to model NGLY1 deficiency, an early-onset neurodegenerative disorder.

[Science Advances] Researchers reported an emerging function for the cytosolic PSD-95 interactor, cypin, in the regulation of synaptic content by K63-polyubiquitin during neuronal development in vitro and in adult mice in vivo.

[PLOS Biology] Scientists focused on Maf1, a repressor of protein synthesis genes transcribed by RNA Polymerase (Pol) III, such as the 5S rRNA and tRNAs, and its role in aging.

[Science Signaling] Investigators used mouse genetic tools to induce astrocyte-specific deletion, overexpression, and chemogenetic activation of RIPK3 to demonstrate an anti-inflammatory function for astrocytic RIPK3.

[Trends In Neurosciences] Transcriptional regulation enables neuron-wide structural adaptations, while synapse-specific transport and maturation ensure localized protein synthesis.

[NPJ Aging ] Scientists provide an overview of how Rab3s dysregulation disrupts neuronal homeostasis, contributing to impaired autophagy, synaptic dysfunction, and eventually leading to neuronal death.

[Journal of Clinical Investigation] Researchers established the bitopertin protoporphyrin IX (PPIX) inhibitory half-maximal effective concentration in a human erythroblast erythropoietic protoporphyria (EPP) model and confirm a marked reduction of PPIX in erythroblasts derived from EPP patients.