Keep Current with the Latest in Cell Biology Research
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Type 1 Diabetes Mellitus Prevention: Present and Future
[Nature Reviews Endocrinology] The authors explore current and potential therapeutics for T1DM prevention. They offer alternative approaches, such as targeting the receptor for advanced glycation end products.
Advancing Therapeutics in Small-Cell Lung Cancer
[Nature Cancer] Investigators highlight key advances in small cell lung cancer biology, therapeutic innovation, and biomarker development. Finally, they discuss the role of reverse translation in optimizing treatments, approaches to overcoming resistance, and ensuring equitable access to care.
The Next Generation of Immunotherapies for Lung Cancers
[Nature Reviews Clinical Oncology] Scientists provide an overview of emerging immunotherapies in clinical development for NSCLC and/or small cell lung cancer, including novel immune-checkpoint modulators, immune cell engagers, adoptive cell therapies, and therapeutic cancer vaccines.
Neural Stem Cells of the Subventricular Zone: A Potential Stem Cell Pool for Brain Repair in Parkinson’S Disease
[Stem Cell Reports] Scientists discuss how Parkinson's disease (PD) pathology affects the behavior of NSCs and current pharmacological strategies to boost regeneration in PD.
Cell Autonomous Microglia Defects in a Stem Cell Model of Frontotemporal Dementia Tau
[Molecular Psychiatry] The authors demonstrated that microtubule-associated protein tau mRNA and tau protein are expressed in microglia in human brains and in hiPSC-derived microglia like cells.
Cytomegalovirus Reactivation in Patients with Large B-Cell Lymphoma Treated with Chimeric Antigen Receptor T-Cell Therapy
[International Journal of Hematology] Using the pp65 antigenemia assay, scientists showed a similar incidence of cytomegalovirus reactivation, onset, and risk factors to those in the previous reports using PCR.
An Endothelial Specific Mouse Model for the Capillary Malformation Mutation Gnaq P.R183Q
[Angiogenesis] Researchers reported a conditional mouse model allowing the simultaneous tissue specific expression of guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) p.R183Q and green fluorescent protein from the Rosa26 locus.
Eno1 in Sepsis-Induced Coagulopathy: A Pleiotropic Mechanism Hypothesis Involving Immunomodulation and Endothelial Dysfunction
[Thrombosis Journal] The authors utilized multi-omics analysis to investigate the Eno1-regulated network, providing a comprehensive understanding of its molecular mechanisms in septic-induced coagulopathy.
Unlocking the Potential: Advancements and Applications of Gene Therapy in Severe Disorders
[Annals of Medicine] The authors summarize recent advances in gene therapy, its background, molecular basis, gene-editing techniques, and its foremost applications in severe disorders, such as cancer, monogenic disorders, etc.
SiRNA-Mediated Knockdown of TOP2B Protects hiPSC-Derived Cardiomyocytes from Doxorubicin-Induced Toxicity.
[Life Sciences] hiPSC-derived cardiomyocytes were treated with siRNA to knock down tTopoisomerase-2 beta and were then exposed to doxorubicin.
Isolation Methods of Exosomes Derived from Dental Stem Cells
[International Journal of Oral Science] Mesenchymal stem cells have been redefined as “medical signaling cells,” with their primary biological effects mediated through exosome secretion. Optimized isolation methods offer a path forward for overcoming current limitations and advancing the clinical use of exosome-based therapies.
Mesoblast Maintains Momentum With FDA on Accelerated Approval Pathway for Revascor® in Ischemic Heart Failure and Label Extension for Ryoncil® in Adults With GvHD
[Mesoblast] Mesoblast provided an update on continued momentum with US FDA regarding both accelerated approval pathway for Revascor® in the treatment of patients with ischemic chronic heart failure with reduced ejection fraction and inflammation, and label extension for Ryoncil® in adults with steroid refractory acute graft versus host disease.