[Chinese Medicine] Scientists constructed a reliable gastric cancer (GC) drug-resistant stem cell model and explore the inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du medicated serum on the drug resistance of GC stem cells based on ABC transporters.

[Molecular Aspects of Medicine] Scientists review recent advances made in understanding the multifaceted roles that CD33 plays in microglia with emphasis on two human-specific CD33 isoforms that differentially correlate with Alzheimer's disease susceptibility.

[Cerevance] Cerevance announced a multi-year strategic research collaboration with Merck, known as MSD outside the United States and Canada, to identify novel targets for Alzheimer’s disease utilizing Cerevance’s proprietary Nuclear Enriched Transcript Sort sequencing technology platform.

[Boston University] Through a five-year, $4 million R01 grant from the National Institutes of Health, Karin Schon plans to examine how cardiorespiratory fitness and chronic psychosocial stress interact to affect the MTH system of the brain in Black emerging adults who are exposed to daily social stress, examined through the lens of racism-rated chronic stress.

[Advanced Healthcare Materials] The wrist and knuckle epitopes of BMP-2 are screened to identify peptides with potential osteogenic properties.

[Cell Biology International] The authors demonstrated that K73-03 effectively inhibited the cell proliferation of pancreatic cells, and induced apoptosis and autophagy of ASPC-1 cells in a dose-dependent manner.

[Oncogenesis] Scientists demonstrated that Zinc finger protein 655 (ZNF655) knockdown inhibited the biological progression of pancreatic cancer cells, which was characterized by weaken proliferation, enhanced apoptosis, arrested cell cycle in G2, impeded migration, and suppressed tumor growth.

[Journal of Biochemical and Molecular Toxicology] The authors verified that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) downregulated glutamine transporter SLC1A5, resulting in excessive reactive oxygen species levels that suppressed tumor growth.

[Nature Communications] Single cell RNA-sequencing analysis of islets from type 1 diabetes patients indicated severe deregulation of the chronic stress-adaptation program and revealed novel biomarkers of diabetes progression.

[Drug Discovery Today] High-content screening has become a strong technology in phenotypic screens because it allows comprehensive screening for the cell-modulatory activity of small molecules.

[Seminars in Cancer Biology] The authors compile the large body of literature that has accumulated in recent years that provides evidence for the mechanisms by which FOXM1 expression promotes stemness in glioblastoma, breast, colon, ovarian, lung, hepatic, and pancreatic carcinomas.

[Journal of Experimental & Clinical Cancer Research] Acylglycerol kinase induced CSC-like properties and was resistant to cisplatin chemotherapy in the epithelial ovarian cancer cells, which were investigated through sphere formation assays and the in vivo model of chemoresistance.