Scientist used quantitative mass-spectrometry-based phosphoproteomics to identify secretory carrier membrane proteins (SCAMP3) as a target of mutant epidermal growth factor receptor in lung adenocarcinoma and further investigated the role of SCAMP3 in the regulation of lung tumorigenesis.
Using chemical genetic screens, scientists identified inhibition of ataxia telangiectasia and rad3 related (ATR), the primary activator of the replication stress response, and topoisomerase I (TOP1), nuclear enzyme that suppressed genomic instability, as synergistically cytotoxic in small cell lung cancer (SCLC).
Researchers detected a focal, canonical hypomethylation phenotype that revealed considerable overlap with hypomethylated regions found in Dnmt3a-deficient mouse skin.
[Proceedings of the National Academy of Sciences of the United States of America]
The authors provide up-to-date information on the best use of currently available immunotherapies in hepatocellular carcinoma and the therapeutic strategies under development.
Scientists showed that glycolysis was significantly enhanced, while the expression of brain and muscle arnt-like protein-1 (Bmal1) was downregulated in fibrotic liver tissues of mice, primary Hepatic stellate cells (HSCs), and transforming growth factor-β1 (TGF-β1)-induced LX2 cells.
Based on the enzyme-mimicking properties, the constructed 2D vanadium carbide MXene nanoenzyme (MXenzyme) not only possessed high biocompatibility but also exhibited robust in vitro cytoprotection against oxidative stress.
To better understand the mechanistic effect cromolyn has in slowing down or halting the neuroinflammatory response associated with Alzheimer’s Disease progression, the authors tested the effect of cromolyn to dampen the inflammatory response in the human HMC3 microglia cell line.
Wang, Y.-J., Monteagudo, A., Downey, M. A., Ashton-Rickardt, P. G., & Elmaleh, D. R. (2021). Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3). Scientific Reports, 11(1), 8054. https://doi.org/10.1038/s41598-021-85702-8Cite
To examine the role of long-range DNA interactions in early development, researchers generated a high-resolution contact map of active enhancers in avian neural crest cells.
Azambuja, A. P., & Simoes-Costa, M. (2021). The connectome of neural crest enhancers reveals regulatory features of signaling systems. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2021.03.024Cite
