[Nature Reviews Endocrinology] The authors explore current and potential therapeutics for T1DM prevention. They offer alternative approaches, such as targeting the receptor for advanced glycation end products.

[Nature Cancer] Investigators highlight key advances in small cell lung cancer biology, therapeutic innovation, and biomarker development. Finally, they discuss the role of reverse translation in optimizing treatments, approaches to overcoming resistance, and ensuring equitable access to care.

[Nature Reviews Clinical Oncology] Scientists provide an overview of emerging immunotherapies in clinical development for NSCLC and/or small cell lung cancer, including novel immune-checkpoint modulators, immune cell engagers, adoptive cell therapies, and therapeutic cancer vaccines.

[Stem Cell Reports] Scientists discuss how Parkinson's disease (PD) pathology affects the behavior of NSCs and current pharmacological strategies to boost regeneration in PD.

[Molecular Psychiatry] The authors demonstrated that microtubule-associated protein tau mRNA and tau protein are expressed in microglia in human brains and in hiPSC-derived microglia like cells.

[International Journal of Hematology] Using the pp65 antigenemia assay, scientists showed a similar incidence of cytomegalovirus reactivation, onset, and risk factors to those in the previous reports using PCR.

[Angiogenesis] Researchers reported a conditional mouse model allowing the simultaneous tissue specific expression of guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) p.R183Q and green fluorescent protein from the Rosa26 locus.

[Thrombosis Journal] The authors utilized multi-omics analysis to investigate the Eno1-regulated network, providing a comprehensive understanding of its molecular mechanisms in septic-induced coagulopathy.

[Annals of Medicine] The authors summarize recent advances in gene therapy, its background, molecular basis, gene-editing techniques, and its foremost applications in severe disorders, such as cancer, monogenic disorders, etc.

[Life Sciences] hiPSC-derived cardiomyocytes were treated with siRNA to knock down tTopoisomerase-2 beta and were then exposed to doxorubicin.

[International Journal of Oral Science] Mesenchymal stem cells have been redefined as “medical signaling cells,” with their primary biological effects mediated through exosome secretion. Optimized isolation methods offer a path forward for overcoming current limitations and advancing the clinical use of exosome-based therapies.

[Mesoblast] Mesoblast provided an update on continued momentum with US FDA regarding both accelerated approval pathway for Revascor^® in the treatment of patients with ischemic chronic heart failure with reduced ejection fraction and inflammation, and label extension for Ryoncil^® in adults with steroid refractory acute graft versus host disease.