Keep Current with the Latest in Cell Biology Research

The Inhibitory Effect and Mechanism of Yi-Qi-Hua-Yu-Jie-Du Decoction on the Drug Resistance of Gastric Cancer Stem Cells Based on ABC Transporters

[Chinese Medicine] Scientists constructed a reliable gastric cancer (GC) drug-resistant stem cell model and explore the inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du medicated serum on the drug resistance of GC stem cells based on ABC transporters.

CD33 Isoforms in Microglia and Alzheimer’s Disease: Friend and Foe

[Molecular Aspects of Medicine] Scientists review recent advances made in understanding the multifaceted roles that CD33 plays in microglia with emphasis on two human-specific CD33 isoforms that differentially correlate with Alzheimer's disease susceptibility.

Cerevance Establishes Strategic Research Collaboration with Merck for the Discovery of Novel Targets in Alzheimer’s Disease

[Cerevance] Cerevance announced a multi-year strategic research collaboration with Merck, known as MSD outside the United States and Canada, to identify novel targets for Alzheimer’s disease utilizing Cerevance’s proprietary Nuclear Enriched Transcript Sort sequencing technology platform.

BU Researcher Receives $4M NIH Grant to Study the Impact of Cumulative Racism on Brain Health

[Boston University] Through a five-year, $4 million R01 grant from the National Institutes of Health, Karin Schon plans to examine how cardiorespiratory fitness and chronic psychosocial stress interact to affect the MTH system of the brain in Black emerging adults who are exposed to daily social stress, examined through the lens of racism-rated chronic stress.

Mimicking Bone Extracellular Matrix: From BMP-2-Derived Sequences to Osteogenic-Multifunctional Coatings

[Advanced Healthcare Materials] The wrist and knuckle epitopes of BMP-2 are screened to identify peptides with potential osteogenic properties.

An Oleanolic Acid Derivative, K73-03, Inhibits Pancreatic Cancer Cells Proliferation In Vitro and In Vivo via Blocking EGFR/Akt Pathway

[Cell Biology International] The authors demonstrated that K73-03 effectively inhibited the cell proliferation of pancreatic cells, and induced apoptosis and autophagy of ASPC-1 cells in a dose-dependent manner.

ZNF655 Accelerates Progression of Pancreatic Cancer by Promoting the Binding of E2F1 and CDK1

[Oncogenesis] Scientists demonstrated that Zinc finger protein 655 (ZNF655) knockdown inhibited the biological progression of pancreatic cancer cells, which was characterized by weaken proliferation, enhanced apoptosis, arrested cell cycle in G2, impeded migration, and suppressed tumor growth.

Synthetic Oleanane Triterpenoid Derivative CDDO-Me Disrupts Cellular Bioenergetics To Suppress Pancreatic Ductal Adenocarcinoma via Targeting SLC1A5

[Journal of Biochemical and Molecular Toxicology] The authors verified that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) downregulated glutamine transporter SLC1A5, resulting in excessive reactive oxygen species levels that suppressed tumor growth.

Adaptation to Chronic ER Stress Enforces Pancreatic β-Cell Plasticity

[Nature Communications] Single cell RNA-sequencing analysis of islets from type 1 diabetes patients indicated severe deregulation of the chronic stress-adaptation program and revealed novel biomarkers of diabetes progression.

Current and Future Approaches for In Vitro Hit Discovery in Diabetes Mellitus

[Drug Discovery Today] High-content screening has become a strong technology in phenotypic screens because it allows comprehensive screening for the cell-modulatory activity of small molecules.

Dysregulated FOXM1 Signaling in the Regulation of Cancer Stem Cells

[Seminars in Cancer Biology] The authors compile the large body of literature that has accumulated in recent years that provides evidence for the mechanisms by which FOXM1 expression promotes stemness in glioblastoma, breast, colon, ovarian, lung, hepatic, and pancreatic carcinomas.

Acylglycerol Kinase Promotes Ovarian Cancer Progression and Regulates Mitochondria Function by Interacting with Ribosomal Protein L39

[Journal of Experimental & Clinical Cancer Research] Acylglycerol kinase induced CSC-like properties and was resistant to cisplatin chemotherapy in the epithelial ovarian cancer cells, which were investigated through sphere formation assays and the in vivo model of chemoresistance.

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