Keep Current with the Latest in Cell Biology Research
Scientist used quantitative mass-spectrometry-based phosphoproteomics to identify secretory carrier membrane proteins (SCAMP3) as a target of mutant epidermal growth factor receptor in lung adenocarcinoma and further investigated the role of SCAMP3 in the regulation of lung tumorigenesis.
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Researchers explored the role of the HIF-1α/NRP1 axis in mediating lung adenocarcinoma metastasis and vasculogenic mimicry (VM) formation.
[Cell Death & Disease]
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Investigators showed that classically activated M1 alveolar macrophages (AMs) facilitated viral spread; however, alternatively activated M2 AMs limited the spread.
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Using chemical genetic screens, scientists identified inhibition of ataxia telangiectasia and rad3 related (ATR), the primary activator of the replication stress response, and topoisomerase I (TOP1), nuclear enzyme that suppressed genomic instability, as synergistically cytotoxic in small cell lung cancer (SCLC).
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Scientists investigated the interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs)
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Researchers detected a focal, canonical hypomethylation phenotype that revealed considerable overlap with hypomethylated regions found in Dnmt3a-deficient mouse skin.
[Proceedings of the National Academy of Sciences of the United States of America]
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The authors provide up-to-date information on the best use of currently available immunotherapies in hepatocellular carcinoma and the therapeutic strategies under development.
[Nature Reviews Gastroenterology & Hepatology]
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Scientists showed that glycolysis was significantly enhanced, while the expression of brain and muscle arnt-like protein-1 (Bmal1) was downregulated in fibrotic liver tissues of mice, primary Hepatic stellate cells (HSCs), and transforming growth factor-β1 (TGF-β1)-induced LX2 cells.
[Acta Pharmaceutica Sinica B]
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Based on the enzyme-mimicking properties, the constructed 2D vanadium carbide MXene nanoenzyme (MXenzyme) not only possessed high biocompatibility but also exhibited robust in vitro cytoprotection against oxidative stress.
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To better understand the mechanistic effect cromolyn has in slowing down or halting the neuroinflammatory response associated with Alzheimer’s Disease progression, the authors tested the effect of cromolyn to dampen the inflammatory response in the human HMC3 microglia cell line.
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To examine the role of long-range DNA interactions in early development, researchers generated a high-resolution contact map of active enhancers in avian neural crest cells.