Keep Current with the Latest in Cell Biology Research
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CDCA7 Enhances STAT3 Transcriptional Activity to Regulate Aerobic Glycolysis and Promote Pancreatic Cancer Progression and Gemcitabine Resistance
[Cell Death & Disease] The authors investigated cell division cycle associated 7 (CDCA7) expression levels and biological functions in pancreatic cancer using in vitro and in vivo experiments.
Disrupting AGR2/IGF1 Paracrine and Reciprocal Signaling for Pancreatic Cancer Therapy
[Cell Reports Medicine] Scientists highlighted the critical role of anterior gradient 2 (AGR2), an endoplasmic reticulum protein disulfide isomerase, secreted by PDAC cells to activate cancer-associated fibroblasts via the Wnt signaling pathway.
FLASH Radiation Reprograms Lipid Metabolism and Macrophage Immunity and Sensitizes Medulloblastoma to CAR T Cell Therapy
[Nature Cancer] Using a genetically engineered mouse model of medulloblastoma, researchers showed that FLASH radiation stimulated proinflammatory polarization in tumor macrophages.
Targeting the TRIM21-PD-1 Axis Potentiates Immune Checkpoint Blockade and CAR T Cell Therapy
[Molecular Therapy] Researchers reported that TRIM21 impaired CD8+ T cell activation and anti-tumor immunity. Mechanistically, TRIM21 catalyzed the K63-linked ubiquitination on PD-1 at K233, leading to stabilization of PD-1 through antagonizing its K48-linked ubiquitination and degradation.
A Comprehensive Spatio-Cellular Map of the Human Hypothalamus
[Nature] Investigators combined single-nucleus sequencing of 433,369 human hypothalamic cells with spatial transcriptomics, generating a comprehensive spatio-cellular transcriptional map of the hypothalamus, the ‘HYPOMAP’.
Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases
[Signal Transduction and Targeted Therapy] The research history and milestone events of studying metal ions in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, ALS, and Huntington’s disease, is introduced.
Mettl3-m6A-NPY Axis Governing Neuron–Microglia Interaction Regulates Sleep Amount of Mice
[Cell Discovery] Investigators showed that the deficiency of RNA N6-methyladenosine (m6A) methyltransferase Mettl3 in excitatory neurons specifically induced microglia activation, neuroinflammation, and neuronal loss in thalamus of mice.
FKBP5 Inhibition Ameliorates Neurodegeneration and Motor Dysfunction in the Neuromelanin-SNCA Mouse Model of Parkinson’s Disease
[Molecular Therapy] To investigate the roles of neuromelanin (NM) and α-syn in dopaminergic neuron degeneration, the authors modeled Parkinson's disease by inducing NM accumulation in a humanized α-syn mouse model via the expression of human tyrosinase in the substantia nigra.
Identification of Mitochondrial Carrier Homolog 2 as an Important Therapeutic Target of Castration-Resistant Prostate Cancer
[Cell Death & Disease] The authors investigated the expression of the mitochondrial carrier homolog 2 and its potential function in castration-resistant prostate cancer.
ATAD2 Drives Prostate Cancer Progression to Metastasis
[Molecular Cancer Research] Researchers employed genetically engineered mouse models of prostate cancer bone metastasis, as well as multiple independent human cohorts, to show that ATAD2 was highly enriched in bone metastasis compared to primary tumors.
JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer
[Cancer Research] Investigators found that aberrant accumulation of jumonji domain containing 6 (JMJD6) proteins correlated with poorer prognosis of prostate cancer patients.
Differential Transport Pathways of Saturated and Unsaturated Fatty Acid Esters in Male Mouse Hepatocytes
[Nature Communications] Scientists found the secretion of unsaturated fatty acid but not saturated fatty acid esters was retarded in a male mouse hepatic endoplasmic reticulum stress model.