Keep Current with the Latest in Cell Biology Research

Caspase-4/11 is Critical for Angiogenesis by Repressing Notch1 Signaling via Inhibiting γ-Secretase Activity

[British Journal of Pharmacology] In vivo, investigators studied the role of Caspase-11 in several angiogenesis mouse models using Caspase-11 wild-type and knockout mice. In vitro, scientists detected the effects of Caspase-4 on endothelial functions and Notch signaling by depleting or overexpressing Caspase-4 in HUVECs.

FGFR1 SUMOylation Coordinates Endothelial Angiogenic Signaling in Angiogenesis

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified the reversible SUMOylation of FGF receptor 1 (FGFR1) as an intrinsic fine-tuned mechanism in coordinating endothelial angiogenic signaling during neovascularization.

MCPIP1 Promotes Cell Proliferation, Migration and Angiogenesis of Glioma via VEGFA-Mediated ERK Pathway

Scientists report that overexpressed MCPIP1 in glioma cells is a boost of angiogenesis. [nan] AbstractGraphical Abstract

Acer Therapeutics Announces Initiation of Its Pivotal Phase III DiSCOVER Trial of EDSIVO™ (Celiprolol) for the Treatment of Vascular Ehlers-Danlos Syndrome

[Acer Therapeutics, Inc.] Acer Therapeutics, Inc. announced the initiation of patient screening in its Phase III DiSCOVER (Decentralized Study of Celiprolol on vEDS-related Event Reduction) clinical trial of EDSIVO (celiprolol) for the treatment of patients with COL3A1-positive vascular Ehlers-Danlos Syndrome.

The Establishment of Polypeptide PSMA-Targeted Chimeric Antigen Receptor-Engineered Natural Killer Cells for Castration-Resistant Prostate Cancer and the Induction of Ferroptosis-Related Cell Death

[Cancer Communications] Scientists designed a novel CAR-natural killer cells with a clinically significant tumoricidal effect on castration-resistant prostate cancer.

The Healing of Bone Defects by Cell-Free and Stem Cell-Seeded 3D-Printed PLA Tissue-Engineered Scaffolds

[Journal of Orthopaedic Surgery and Research] The authors showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively.

Long-Term Hematopoietic Stem Cells as a Parasite Niche during Treatment Failure in Visceral Leishmaniasis

[Communications Biology] Double bioluminescent/fluorescent Leishmania infantum and L. donovani reporter lines enabled the identification of long-term hematopoietic stem cells as a niche in the bone marrow with remarkably high parasite burdens, a feature confirmed for human hematopoietic stem cells.

Kinetics of Disappearance and Appearance of Isoagglutinins A and B after ABO-Incompatible Hematopoietic Stem Cell Transplantation

[Bone Marrow Transplantation] In a one-year follow-up, data of 136 ABO-incompatible hematopoietic stem cell allogeneic transplanted patients were studied, of which 60 had major, 61 minor and 15 bidirectional incompatibility.

Acute Kidney Injury within 100 Days Post Allogeneic Hematopoietic Cell Transplantation Is Associated with Increased Risk of Post-Transplant Complications and Poor Transplant Outcomes

[Bone Marrow Transplantation] Researchers investigated the incidence of AKI and its impact on transplant outcomes among 408 patients transplanted at Princess Margaret Hospital Cancer Centre, Toronto, Canada.

miR-107 Attenuates Sepsis-Induced Myocardial Injury by Targeting PTEN and Activating the PI3K/AKT Signaling Pathway

[Cells Tissues Organs] Scientists investigated the mechanism of miR-107 on sepsis-induced myocardial injury. Sepsis rat models were established by cecal ligation and puncture, and the cell model was established using lipopolysaccharide-induced cardiomyocytes.

A Carbon-Based Biosensing Platform for Simultaneously Measuring the Contraction and Electrophysiology of iPSC-Cardiomyocyte Monolayers

[ACS Nano] Researchers developed a biosensing platform that was capable of performing on-chip and simultaneous measurement of contractility and electrophysiology of human induced pluripotent stem-cell-derived (iPSC) cardiomyocyte monolayers.

Identification and in vitro Characterization of a New Series of Potent and Highly Selective G9a Inhibitors as Novel Anti-Fibroadipogenic Agents

[Bioorganic & Medicinal Chemistry Letters] A new series of in vitro potent and highly selective histone methyl transferase enzyme G9a inhibitors was obtained. In particular, compound 2a, one the most potent G9a inhibitor identified, was endowed with >130-fold selectivity over GLP and excellent ligand efficiency.

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