Keep Current with the Latest in Cell Biology Research
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[Diabetes Center Berne (BusinessWire, Inc.)]
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Dexcom, Inc. (NASDAQ: DXCM), a leader in real-time continuous glucose monitoring (CGM), announced today that people with diabetes who are on intensive insulin therapy, age two years or older, may now be eligible for provincial coverage of the Dexcom G6 CGM System through BC PharmaCare.
[Dexcom, Inc. (BusinessWire, Inc.)]
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Researchers reported the largest and most diverse genetic study of type 1 diabetes to date, yielding 78 genome-wide-significant regions, including 36 that are new.
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Robertson, C. C., Inshaw, J. R. J., Onengut-Gumuscu, S., Chen, W.-M., Santa Cruz, D. F., Yang, H., Cutler, A. J., Crouch, D. J. M., Farber, E., Bridges, S. L., Edberg, J. C., Kimberly, R. P., Buckner, J. H., Deloukas, P., Divers, J., Dabelea, D., Lawrence, J. M., Marcovina, S., Shah, A. S., … Rich, S. S. (2021). Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nature Genetics, 1–10. https://doi.org/10.1038/s41588-021-00880-5 Cite
Scientists showed that oncogenic KRAS promoted protein kinase C-mediated NAD+ kinase (NADK) phosphorylation, leading to its hyperactivation, thus sustaining both NADP+ and NADPH levels in pancreatic ductal adenocarcinoma cells.
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Schild, T., McReynolds, M. R., Shea, C., Low, V., Schaffer, B. E., Asara, J. M., Piskounova, E., Dephoure, N., Rabinowitz, J. D., Gomes, A. P., & Blenis, J. (2021). NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Reports, 35(11). https://doi.org/10.1016/j.celrep.2021.109238 Cite
Investigators showed that basic nitrogen-containing residues blocked central adverse events of Dextromethorphan without reducing its anti-diabetic effects, including the protection of human pancreatic islets from cell death.
[Cell Chemical Biology]
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Scholz, O., Otter, S., Welters, A., Wörmeyer, L., Dolenšek, J., Klemen, M. S., Pohorec, V., Eberhard, D., Mrugala, J., Hamacher, A., Koch, A., Sanz, M., Hoffmann, T., Hogeback, J., Herebian, D., Klöcker, N., Piechot, A., Mayatepek, E., Meissner, T., … Lammert, E. (2021). Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2021.05.011 Cite
Researchers found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice.
[Cell Death & Disease]
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Scientists provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+ cell population.
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Tian, J.-Z., Xing, S., Feng, J.-Y., Yang, S.-H., Ding, Y.-F., Huang, X.-T., Yang, J.-S., & Yang, W.-J. (2021). SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury. Scientific Reports, 11(1), 12614. https://doi.org/10.1038/s41598-021-92075-5 Cite
Researchers suggested that missense p53 mutations might contribute to worse pancreatic ductal adenocarcinoma prognosis by promoting a more vigorous fibrotic tumor microenvironment and impeding the ability of the immune system to eliminate the cancer cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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Maddalena, M., Mallel, G., Nataraj, N. B., Shreberk-Shaked, M., Hassin, O., Mukherjee, S., Arandkar, S., Rotkopf, R., Kapsack, A., Lambiase, G., Pellegrino, B., Ben-Isaac, E., Golani, O., Addadi, Y., Hajaj, E., Eilam, R., Straussman, R., Yarden, Y., Lotem, M., & Oren, M. (2021). TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment. Proceedings of the National Academy of Sciences, 118(23). https://doi.org/10.1073/pnas.2025631118 Cite
Oncolytic viral chimera, CF33-hNIS-antiPDL1 genetically modified to express anti-human PD-L1 antibody and CF33-hNIS-Δ without the anti-PD-L1 gene, were used to investigate the immunogenic effects of oncolytic virus and virus-delivered anti-PD-L1 in pancreatic ductal adenocarcinoma in vitro.
[Cancer Gene Therapy]
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Zhang, Z., Yang, A., Chaurasiya, S., Park, A. K., Lu, J., Kim, S.-I., Warner, S. G., Yuan, Y.-C., Liu, Z., Han, H., Von Hoff, D., Fong, Y., & Woo, Y. (2021). CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy. Cancer Gene Therapy, 1–12. https://doi.org/10.1038/s41417-021-00350-4 Cite
Scientists found that EPCAM + tumors developed in the mouse pancreas store zinc that is detectable by fluorescence-activated cell sorting using N-(6-methoxy-8-quinolyl)-p-toluenesulfonamide (TSQ), a fluorescence chelator. EPCAM + TSQ + tumor cells isolated from the mouse pancreas formed organoids in matrigel.
[Biological Trace Element Research]
Human pancreatic cancer cells MIA-Pa-Ca-2 were treated with the phytochemicals alone or their equimolar mixture for 24 h and activation of Nrf2 and expression of its target genes were evaluated.
[Nutrition and Cancer-An International Journal]
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Cykowiak, M., Krajka-Kuźniak, V., & Baer-Dubowska, W. (2021). Combinations of Phytochemicals More Efficiently than Single Components Activate Nrf2 and Induce the Expression of Antioxidant Enzymes in Pancreatic Cancer Cells. Nutrition and Cancer, 0(0), 1–16. https://doi.org/10.1080/01635581.2021.1933097 Cite