Britya Ghosh

Cancer Stem Cell News

Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via the PI3K Pathway

[Journal of Immunology Research] Hypoxia induced by using CoCl2 application and 14-3-3β protein knockdown by specific small interfering RNA transfection were performed in GSCs both in vitro and in vivo to observe their role in glioma progression and metastasis occurrence by using western blot analysis and MTT assay.

Cancer Stem Cell News

Reflected Stemness as a Potential Driver of the Tumor Microenvironment

[Trends in Cell Biology] Investigators suggested that focusing on the early interaction between stem cells harbouring mutations in cancer-driver genes and the surrounding tissue cells, which might also carry genetic mutations, might hold the key to this understanding.

Hematopoiesis News

Foghorn Therapeutics Provides Update on Phase I Study of FHD-286 in Relapsed and/or Refractory AML and MDS

[Foghorn Therapeutics, Inc. (BioSpace, Inc.)] Foghorn Therapeutics Inc. announced the FDA has placed the Phase I dose escalation study of FHD-286 in relapsed and/or refractory acute myelogenous leukemia and myelodysplastic syndrome on a partial clinical hold.

Hematopoiesis News

Inhibition of Mitochondrial Complex I Reverses NOTCH1-Driven Metabolic Reprogramming in T-cell Acute Lymphoblastic Leukemia

[Nature Communications] Researchers identified oxidative phosphorylation as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NOTCH1, elevated OxPhos gene expression, and acquired chemoresistance in pre-leukemic and leukemic models.

Hematopoiesis News

Inability to Phosphorylate Y88 of p27Kip1 Enforces Reduced p27 Protein Levels and Accelerates Leukemia Progression

[Leukemia] To investigate the physiological significance of p27 tyrosine phosphorylation, scientists generated a knock-in mouse model where Y88 was replaced by phenylalanine.

Hematopoiesis News

Developmental Cues License Megakaryocyte Priming in Murine Hematopoietic Stem Cells

[Blood Advances] The authors identified LIN28B known for its role in promoting fetal-like self-renewal, as an insulator against the establishment of a megakaryocyte biased hematopoietic stem cell pool.

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Arginine Ingestion Inhibits Phagocyte Invasion in Eccentrically Contracted Rat Fast-Twitch Muscle

[Journal of Muscle Research and Cell Motility] Scientists investigated whether prior ingestion of L-arginine, a nitric oxide precursor, inhibited eccentric contraction-induced macrophage invasion.

KLF13 Promotes VSMCs Phenotypic Dedifferentiation by Directly Binding to the SM22α Promoter

[Journal of Cellular Physiology] The authors investigated the relationship between KLF13 and SM22α expression in normal and atherosclerotic plaques by bioanalysis, and observed a significant increase in KLF13 levels in the atherosclerotic plaques of both human patients and ApoE−/− mice.

Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension

[Circulation Research] Researchers studied cyclophilin D (CypD) acetylation in patients with essential hypertension, defined a pathogenic role of CypD acetylation in deacetylation mimetic CypD-K166R mutant mice and endothelial-specific general control of amino acid synthesis 5 like 1–deficient mice using an angiotensin II model of hypertension.

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Britya Ghosh

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