All Articles by Author:

Britya Ghosh

Role of CDH23 as a Prognostic Biomarker and Its Relationship with Immune Infiltration in Acute Myeloid Leukemia

[BMC Cancer] The authors found that the CDH23 expression was aberrantly upregulated in patients with acute myeloid leukemia and could be used as an independent risk factor of overall survival using Cox multivariate analysis.

15-PGDH Regulates Hematopoietic and Gastrointestinal Fitness during Aging

[PLoS One] Researchers demonstrated that genetic loss of 15-PGDH (Hpgd) confers a protective effect on aging of murine hematopoietic and gastrointestinal tissues.

Acute Lymphoblastic Leukemia Displays a Distinct Highly Methylated Genome

[Nature Cancer] Scientists performed whole-genome bisulfite sequencing across ALL subtypes, leukemia cell lines and healthy hematopoietic cells, and showed that unlike most cancers, ALL samples exhibited CpG island hypermethylation but minimal global loss of methylation.

Post-Transplant Cyclophosphamide Alters Immune Signatures and Leads to Impaired T Cell Reconstitution in Allogeneic Hematopoietic Stem Cell Transplant

[Journal of Hematology & Oncology] Using blood samples from patients who underwent allogeneic hematopoietic stem cell transplantation under regimens containing post-transplant cyclophosphamide (PTCy) versus those who received no PTCy, researchers examined the impact of PTCy on the post-transplant immune response.

A Phase I/IIa Clinical Trial of Autologous Hematopoietic Stem Cell Transplantation in Amyotrophic Lateral Sclerosis

[Journal of Neurology] To verify the safety and potential effect on ALS progression of a low-intensity immunosuppressive regimen followed by autologous hematopoietic stem cell transplantation in amyotrophic lateral sclerosis patients.

Significance of Alveolar Nitric Oxide Concentration in the Airway of Patients with Organizing Pneumonia after Allogeneic Hematopoietic Stem Cell Transplantation

[Annals of Hematology] Researchers evaluated whether alveolar nitric oxide concentration levels could reflect the presence of Organizing pneumonia and structural airway changes in patients after allo-hematopoietic stem cell transplantation.

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TGR5-Mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Circuit Regulates Depressive-Like Behavior in Male Mice

[Neuron] Using depression models of chronic social defeat stress and chronic restraint stress in male mice, researchers found that TGR5 in the lateral hypothalamic area predominantly decreased in GABAergic neurons, the excitability of which increased in depressive-like mice.

Feedforward and Feedback Mechanisms Cooperatively Regulate Rapid Experience-Dependent Response Adaptation in a Single Thermosensory Neuron Type

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers showed that rapid thermosensory response adaptation in AFD was mediated via cGMP and calcium-dependent feedforward and feedback mechanisms operating at the level of primary thermotransduction.

Glucosylceramide Accumulation in Microglia Triggers STING-Dependent Neuroinflammation and Neurodegeneration in Mice

[Science Signaling] Scientists investigated the mechanisms by which glucosylceramide (GC) accumulation induced neuroinflammation. They found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo.