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Danielle Corrigan

Mitochondrial Fragmentation in Liver Cancer: Emerging Player and Promising Therapeutic Opportunities

[Cancer Letters] Scientists describe the mechanisms by which mitochondrial fragmentation (MF) contributes to HCC development, discuss potential therapeutic approaches, and the possibility that MF modulation has a synergistic effect with immunotherapy.

FDA Grants GENFIT’s GNS561 Orphan Drug Designation for the Treatment of Cholangiocarcinoma

[GENFIT] GENFIT announced that the US FDA has granted orphan drug designation to GNS5611 (ezurpimtrostat), a novel clinical-stage autophagy/PPT1 inhibitor, for the treatment of cholangiocarcinoma.

Transgenic Construction and Functional miRNA Analysis Identify the Role of miR-7 in Prostate Cancer Suppression

[Oncogene] The authors found that expression of miR-7, regulated by p53, was lower in prostate cancer tissues, and miR-7 overexpression significantly mitigated prostate cancer cells growth both in vitro, in organoids, and in vivo regardless of p53 status.

Transcriptional Profiling of Matched Patient Biopsies Clarifies Molecular Determinants of Enzalutamide-Induced Lineage Plasticity

[Nature Communications] To improve our understanding of enza resistance, the authors analyzed the transcriptomes of matched biopsies from men with metastatic CRPC obtained prior to treatment and at progression.

Decidual Dendritic Cells 10 and CD4+MCD25+FOXP3 Regulatory T Cell in Preeclampsia and Their Correlation With Nutritional Factors in Pathomechanism of Immune Rejection in Pregnancy

[Journal of Reproductive Immunology] Researchers conducted a cross-sectional study among early onset preeclampsia, late onset preeclampsia, and normotensive pregnancies. The number of decidual dendritic cell-10 and Treg cells were counted using flow cytometry.

Liver Organoids: An In Vitro 3D Model for Liver Cancer Study

[Cell & Bioscience] The authors summarize the categories and development of liver organoids, and focus on the functions of culture medium components and applications of organoids for hepatitis B virus infection and associated liver cancer studies.

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TGR5-Mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Circuit Regulates Depressive-Like Behavior in Male Mice

[Neuron] Using depression models of chronic social defeat stress and chronic restraint stress in male mice, researchers found that TGR5 in the lateral hypothalamic area predominantly decreased in GABAergic neurons, the excitability of which increased in depressive-like mice.

Feedforward and Feedback Mechanisms Cooperatively Regulate Rapid Experience-Dependent Response Adaptation in a Single Thermosensory Neuron Type

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers showed that rapid thermosensory response adaptation in AFD was mediated via cGMP and calcium-dependent feedforward and feedback mechanisms operating at the level of primary thermotransduction.

Glucosylceramide Accumulation in Microglia Triggers STING-Dependent Neuroinflammation and Neurodegeneration in Mice

[Science Signaling] Scientists investigated the mechanisms by which glucosylceramide (GC) accumulation induced neuroinflammation. They found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo.