Danielle Corrigan

Hepatic Cell News

Mitochondrial Fragmentation in Liver Cancer: Emerging Player and Promising Therapeutic Opportunities

[Cancer Letters] Scientists describe the mechanisms by which mitochondrial fragmentation (MF) contributes to HCC development, discuss potential therapeutic approaches, and the possibility that MF modulation has a synergistic effect with immunotherapy.

Hepatic Cell News

FDA Grants GENFIT’s GNS561 Orphan Drug Designation for the Treatment of Cholangiocarcinoma

[GENFIT] GENFIT announced that the US FDA has granted orphan drug designation to GNS5611 (ezurpimtrostat), a novel clinical-stage autophagy/PPT1 inhibitor, for the treatment of cholangiocarcinoma.

Newsletters

Transgenic Construction and Functional miRNA Analysis Identify the Role of miR-7 in Prostate Cancer Suppression

[Oncogene] The authors found that expression of miR-7, regulated by p53, was lower in prostate cancer tissues, and miR-7 overexpression significantly mitigated prostate cancer cells growth both in vitro, in organoids, and in vivo regardless of p53 status.

Newsletters

Transcriptional Profiling of Matched Patient Biopsies Clarifies Molecular Determinants of Enzalutamide-Induced Lineage Plasticity

[Nature Communications] To improve our understanding of enza resistance, the authors analyzed the transcriptomes of matched biopsies from men with metastatic CRPC obtained prior to treatment and at progression.

Human Immunology News

Decidual Dendritic Cells 10 and CD4+MCD25+FOXP3 Regulatory T Cell in Preeclampsia and Their Correlation With Nutritional Factors in Pathomechanism of Immune Rejection in Pregnancy

[Journal of Reproductive Immunology] Researchers conducted a cross-sectional study among early onset preeclampsia, late onset preeclampsia, and normotensive pregnancies. The number of decidual dendritic cell-10 and Treg cells were counted using flow cytometry.

Hepatic Cell News

Liver Organoids: An In Vitro 3D Model for Liver Cancer Study

[Cell & Bioscience] The authors summarize the categories and development of liver organoids, and focus on the functions of culture medium components and applications of organoids for hepatitis B virus infection and associated liver cancer studies.

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Innate Immune Cell Functions Contribute to Spontaneous HIV Control

[Current HIV/Aids Reports] The authors review the role of innate immune cells in shaping the viral reservoir and maintenance of long-term viral control of spontaneous Elite and Viremic HIV controllers.

Dyadic Receives $3 Million Grant to Develop Cost-Effective Monoclonal Antibodies for RSV and Malaria Using C1 Platform Technology

[Dyadic International, Inc.] Dyadic International, Inc. announced that it has been awarded a $3 million grant from the Gates Foundation for the cell line development of monoclonal antibodies targeting respiratory syncytial virus (RSV) and malaria utilizing the company’s proprietary C1 protein production platform to provide globally accessible treatment options for underserved populations.

CAR-T Cell Therapy: Challenge and Opportunity for Effective Treatment of Small Cell Lung Cancer

[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists characterized the biological signature of small cell lung cancer and outline the obstacles to current treatment, including impaired antigen presentation and T cell infiltration.

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Danielle Corrigan

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