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Danielle Corrigan
Extracellular Matrix News
Fast Construction of Biomimetic Organic-inorganic Interface by Crosslinking of Calcium Phosphate Oligomers: A Strategy for Instant Regeneration of Hard Tissue
[Advanced Healthcare Materials] Investigators demonstrated a fast in situ crosslinking of calcium phosphate oligomers on collagen matrixes for efficient organic-inorganic interface re-construction, which could result in a biomimetic hybrid.
Extracellular Matrix News
Virogin Biotech and MD Anderson Announce Strategic Collaboration to Accelerate Oncolytic Virus Research and Development for Treating Advanced Cancers
[Virogin Biotech (Globe Newswire, Inc.)] Virogin Biotech and The University of Texas MD Anderson Cancer Center announced a strategic collaboration to accelerate the development of investigational treatments, including oncolytic viruses and immunotherapies, for patients with advanced cancers.
Cell Therapy News
Anti-CD19 Car T Cell Therapy for Refractory Systemic Lupus Erythematosus
[Nature Medicine] Autologous T cells from patients with systemic lupus erythematosus were transduced with a lentiviral anti-CD19 CAR vector, expanded and reinfused at a dose of 1 × 106 CAR T cells per kilogram of body weight into the patients after lymphodepletion with fludarabine and cyclophosphamide.
Immunology of Infectious Disease News
Identification of Immunomodulatory Drugs That Inhibit Multiple Inflammasomes and Impair SARS-CoV-2 Infection
[Science Advances] The authors performed a high-throughput screening using a 2560 small-molecule compound library and identified FDA-approved drugs that functioned as pan-inflammasome inhibitors.
Immunology of Infectious Disease News
A Lipoglycopeptide Antibiotic for Gram-Positive Biofilm-Related Infections
[Science Translational Medicine] Scientists developed a preclinical glycopeptide antibiotic, MCC5145, that had excellent potency against hundreds of isolates of methicillin-resistant S. aureus and other Gram-positive bacteria, with a greater than 1000-fold margin over mammalian cell cytotoxicity values.
Newsletters
AIM2 Upregulation Promotes the Metastatic Progression and Pd-L1 Expression in Lung Adenocarcinoma
[Cancer Science] Scientists showed that the mRNA levels of absence in melanoma 2 (AIM2), one of the inflammasome members, were extensively upregulated in primary tumors compared to normal tissues derived from the TCGA lung adenocarcinoma database.
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Myosin-Binding Protein C Regulates the Sarcomere Lattice and Stabilizes the OFF States of Myosin Heads
[Nature Communications] Investigators used a combination of mechanics and small-angle X-ray diffraction to study the immediate and selective removal of the myosin-binding protein C (MyBP-C) C1C7 domains of fast MyBP-C in permeabilized skeletal muscle.
MST1/2 Regulates Fibro/Adipogenic Progenitor Fate Decisions in Skeletal Muscle Regeneration
[Stem Cell Reports] Using inducible conditional knockout mice, the authors showed that blocking mammalian Ste20-like kinases 1/2 (MST1/2) of fibroblast/adipose progenitors prevented apoptosis and reduced interleukin-6 secretion in vivo and in vitro.
Yin Yang 1 Regulates Cohesin Complex Protein SMC3 in Mouse Hematopoietic Stem Cells
[Blood Advances] Researchers found that Yin Yang 1 (YY1) physically interacted with structural maintenance of chromosomes 3 (SMC3) and co-occupied with SMC3 at a large cohort of promoters genome-wide, and YY1 deficiency deregulated the genetic network governing cell metabolism.