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Danielle Corrigan

Fast Construction of Biomimetic Organic-inorganic Interface by Crosslinking of Calcium Phosphate Oligomers: A Strategy for Instant Regeneration of Hard Tissue

[Advanced Healthcare Materials] Investigators demonstrated a fast in situ crosslinking of calcium phosphate oligomers on collagen matrixes for efficient organic-inorganic interface re-construction, which could result in a biomimetic hybrid.

Virogin Biotech and MD Anderson Announce Strategic Collaboration to Accelerate Oncolytic Virus Research and Development for Treating Advanced Cancers

[Virogin Biotech (Globe Newswire, Inc.)] Virogin Biotech and The University of Texas MD Anderson Cancer Center announced a strategic collaboration to accelerate the development of investigational treatments, including oncolytic viruses and immunotherapies, for patients with advanced cancers.

Anti-CD19 Car T Cell Therapy for Refractory Systemic Lupus Erythematosus

[Nature Medicine] Autologous T cells from patients with systemic lupus erythematosus were transduced with a lentiviral anti-CD19 CAR vector, expanded and reinfused at a dose of 1 × 106 CAR T cells per kilogram of body weight into the patients after lymphodepletion with fludarabine and cyclophosphamide.

Identification of Immunomodulatory Drugs That Inhibit Multiple Inflammasomes and Impair SARS-CoV-2 Infection

[Science Advances] The authors performed a high-throughput screening using a 2560 small-molecule compound library and identified FDA-approved drugs that functioned as pan-inflammasome inhibitors.

A Lipoglycopeptide Antibiotic for Gram-Positive Biofilm-Related Infections

[Science Translational Medicine] Scientists developed a preclinical glycopeptide antibiotic, MCC5145, that had excellent potency against hundreds of isolates of methicillin-resistant S. aureus and other Gram-positive bacteria, with a greater than 1000-fold margin over mammalian cell cytotoxicity values.

AIM2 Upregulation Promotes the Metastatic Progression and Pd-L1 Expression in Lung Adenocarcinoma

[Cancer Science] Scientists showed that the mRNA levels of absence in melanoma 2 (AIM2), one of the inflammasome members, were extensively upregulated in primary tumors compared to normal tissues derived from the TCGA lung adenocarcinoma database.

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Myosin-Binding Protein C Regulates the Sarcomere Lattice and Stabilizes the OFF States of Myosin Heads

[Nature Communications] Investigators used a combination of mechanics and small-angle X-ray diffraction to study the immediate and selective removal of the myosin-binding protein C (MyBP-C) C1C7 domains of fast MyBP-C in permeabilized skeletal muscle.

MST1/2 Regulates Fibro/Adipogenic Progenitor Fate Decisions in Skeletal Muscle Regeneration

[Stem Cell Reports] Using inducible conditional knockout mice, the authors showed that blocking mammalian Ste20-like kinases 1/2 (MST1/2) of fibroblast/adipose progenitors prevented apoptosis and reduced interleukin-6 secretion in vivo and in vitro.

Yin Yang 1 Regulates Cohesin Complex Protein SMC3 in Mouse Hematopoietic Stem Cells

[Blood Advances] Researchers found that Yin Yang 1 (YY1) physically interacted with structural maintenance of chromosomes 3 (SMC3) and co-occupied with SMC3 at a large cohort of promoters genome-wide, and YY1 deficiency deregulated the genetic network governing cell metabolism.