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Ishira
Mesenchymal Cell News
Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes for Treating Traumatic Pancreatitis in Rats
[Stem Cell Research & Therapy] Scientists established a rat model of traumatic pancreatitis and evaluated and compared the therapeutic effects of human umbilical cord (hUC)-MSCs and hucMSC-exosomes.
Mesenchymal Cell News
Standard Toxicity Study of Clinical-Grade Allogeneic Human Bone Marrow-Derived Clonal Mesenchymal Stromal Cells
[Stem Cell Research & Therapy] Investigators determined the probable toxicity effects of local and systemic injections of cryopreserved human bone marrow-derived clonal MSCs during subacute and subchronic periods of time.
Mesenchymal Cell News
Magnetic Exposure Using Samarium Cobalt (SmCO5) Increased Proliferation and Stemness of Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs)
[Scientific Reports] Researchers investigated the impact of induced static MF on hUC-MSCs using SmCO5.
Cancer Stem Cell News
Knockdown of the Stem Cell Marker Musashi-1 Inhibits Endometrial Cancer Growth and Sensitizes Cells to Radiation
[Stem Cell Research & Therapy] Musashi-1 knockdown resulted in a strong decrease in endometrial cancer proliferation and a loss of radioresistance, suggesting therapeutic potential.
Newsletters
Suppression of Nuclear GSK3 Signaling Promotes Serine/One-Carbon Metabolism and Confers Metabolic Vulnerability in Lung Cancer Cells
[Science Advances] Scientists uncovered a critical role of glycogen synthase kinase 3 (GSK3) in regulating the expression of serine/one-carbon metabolic enzymes.
Newsletters
MERS-CoV Endoribonuclease and Accessory Proteins Jointly Evade Host Innate Immunity during Infection of Lung and Nasal Epithelial Cells
[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated the antagonist effects of the conserved coronavirus endoribonuclease, in combination with NS4a or NS4b.
Popular
Myosin-Binding Protein C Regulates the Sarcomere Lattice and Stabilizes the OFF States of Myosin Heads
[Nature Communications] Investigators used a combination of mechanics and small-angle X-ray diffraction to study the immediate and selective removal of the myosin-binding protein C (MyBP-C) C1C7 domains of fast MyBP-C in permeabilized skeletal muscle.
MST1/2 Regulates Fibro/Adipogenic Progenitor Fate Decisions in Skeletal Muscle Regeneration
[Stem Cell Reports] Using inducible conditional knockout mice, the authors showed that blocking mammalian Ste20-like kinases 1/2 (MST1/2) of fibroblast/adipose progenitors prevented apoptosis and reduced interleukin-6 secretion in vivo and in vitro.
Yin Yang 1 Regulates Cohesin Complex Protein SMC3 in Mouse Hematopoietic Stem Cells
[Blood Advances] Researchers found that Yin Yang 1 (YY1) physically interacted with structural maintenance of chromosomes 3 (SMC3) and co-occupied with SMC3 at a large cohort of promoters genome-wide, and YY1 deficiency deregulated the genetic network governing cell metabolism.