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Ishira

Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes for Treating Traumatic Pancreatitis in Rats

[Stem Cell Research & Therapy] Scientists established a rat model of traumatic pancreatitis and evaluated and compared the therapeutic effects of human umbilical cord (hUC)-MSCs and hucMSC-exosomes.

Standard Toxicity Study of Clinical-Grade Allogeneic Human Bone Marrow-Derived Clonal Mesenchymal Stromal Cells

[Stem Cell Research & Therapy] Investigators determined the probable toxicity effects of local and systemic injections of cryopreserved human bone marrow-derived clonal MSCs during subacute and subchronic periods of time.

Knockdown of the Stem Cell Marker Musashi-1 Inhibits Endometrial Cancer Growth and Sensitizes Cells to Radiation

[Stem Cell Research & Therapy] Musashi-1 knockdown resulted in a strong decrease in endometrial cancer proliferation and a loss of radioresistance, suggesting therapeutic potential.

Suppression of Nuclear GSK3 Signaling Promotes Serine/One-Carbon Metabolism and Confers Metabolic Vulnerability in Lung Cancer Cells

[Science Advances] Scientists uncovered a critical role of glycogen synthase kinase 3 (GSK3) in regulating the expression of serine/one-carbon metabolic enzymes.

MERS-CoV Endoribonuclease and Accessory Proteins Jointly Evade Host Innate Immunity during Infection of Lung and Nasal Epithelial Cells

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated the antagonist effects of the conserved coronavirus endoribonuclease, in combination with NS4a or NS4b.

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Myosin-Binding Protein C Regulates the Sarcomere Lattice and Stabilizes the OFF States of Myosin Heads

[Nature Communications] Investigators used a combination of mechanics and small-angle X-ray diffraction to study the immediate and selective removal of the myosin-binding protein C (MyBP-C) C1C7 domains of fast MyBP-C in permeabilized skeletal muscle.

MST1/2 Regulates Fibro/Adipogenic Progenitor Fate Decisions in Skeletal Muscle Regeneration

[Stem Cell Reports] Using inducible conditional knockout mice, the authors showed that blocking mammalian Ste20-like kinases 1/2 (MST1/2) of fibroblast/adipose progenitors prevented apoptosis and reduced interleukin-6 secretion in vivo and in vitro.

Yin Yang 1 Regulates Cohesin Complex Protein SMC3 in Mouse Hematopoietic Stem Cells

[Blood Advances] Researchers found that Yin Yang 1 (YY1) physically interacted with structural maintenance of chromosomes 3 (SMC3) and co-occupied with SMC3 at a large cohort of promoters genome-wide, and YY1 deficiency deregulated the genetic network governing cell metabolism.