lbeveridge

[Nucleic Acids Research] The authors prepared numerous RNA substrates, including both long substrates mimicking the viral genome and short defined RNA, to clarify the substrate preference and cleavage pattern of SARS-CoV-2 nsp15.

[Molecular Cancer] Investigators bridge the gap between discovering element genes to a specific process of T cell activities and apprehending these genes in the global T cell life cycle, deepened the understanding of T cell biology in tumour immunity, and outline CRISPR screens resources that might facilitate the development and implementation of cancer immunotherapies in the clinic.

[Molecular Cancer] The authors explore the dynamic interactions among T and B cell subpopulations of varying phenotypes that contribute to the structural and functional diversity of TLS, examining both existing and emerging techniques for TLS imaging and induction, focusing on cancer immunotherapies and biomaterials.

[Advanced Materials] Scientists manipulated the immunopotentiator manganese into six differing structures that resemble the architectures of two types of pathogens. They revealed that innate immune cells accurately sense and respond to the architectures, of which two outperformed material candidates showedhigher competence in creating local pro-inflammatory environment with promoted innate immune cell influx and stimulatory effects on multiple subsets of dendritic cells.

[Journal For Immunotherapy Of Cancer] Scientists investigated therapy-mediated immunological alterations in the tumor microenvironment and tumor-draining lymph nodes in the D4M.3A preclinical melanoma mouse model by using high-dimensional multicolor flow cytometry in combination with multiplex immunohistochemistry.

[University of Waterloo] Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.