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U of A Oncology Researcher Named to the Order of Canada

[University of Alberta] Vickie Baracos, University of Alberta oncology professor, researcher and Alberta Cancer Foundation Chair in Palliative Medicine from 2003-23, was recently awarded the Order of Canada. She was honoured for her groundbreaking insights into the fundamental biology of cachexia.

3D Matrix Stiffness Modulation Unveils Cardiac Fibroblast Phenotypic Switching

[Scientific Reports] Using hybrid hydrogels with tunable stiffness, the authors created an in vitro model to mimic the varying stiffness of the cardiac microenvironment.

Single-Cell Analysis Reveals Transcriptional Dynamics in Healthy Primary Parathyroid Tissue

[Genome Research] Researchers sequenced, as a comparator, four histologically characterized hyperfunctioning human parathyroids with varying oxyphil and chief cell abundance and leveraged advanced computational techniques to highlight similarities and differences from non-human primate parathyroid expression dynamics. P

In Situ Triggered Self-Contraction Bioactive Microgel Assembly Accelerates Diabetic Skin Wound Healing by Activating Mechanotransduction and Biochemical Pathway

[Advanced Materials] The authors advanced self-contraction bioactive core-shell microgel assembly with robust tissue-adhesion was introduced to expedite diabetic wound healing.

Single-Cell Analysis Reveals Transcriptional Dynamics in Healthy Primary Parathyroid Tissue

[Clinical Cancer Research] The authors investigated the influence of IDH status on the myeloid compartment using human glioma specimens and preclinical models.

Designer Cellular Spheroids with DNA Origami for Drug Screening

[Science Advances] Investigators introduced a method that uses self-assembling nucleic acid nanostructures decorated living cells, termed NACs, to create spheroids with a customizable 3D layout.


Five Harvard Medical School Faculty Named HHMI Investigators

[Harvard Medical School] Five researchers from Harvard Medical School have been named among 26 new HHMI Investigators by the Howard Hughes Medical Institute (HHMI).

Shifts in Receptors during Submergence of an Encephalitic Arbovirus

[Nature] Investigators identified protocadherin 10 (PCDH10) as a cellular receptor for Western equine encephalitis virus (WEEV). They showed that multiple highly virulent ancestral WEEV strains isolated in the 1930s and 1940s, in addition to binding human PCDH10, could also bind very low-density lipoprotein receptor and apolipoprotein E receptor 2.

Glycan-Shielded Homodimer Structure and Dynamical Features of the Canine Distemper Virus Hemagglutinin Relevant for Viral Entry and Efficient Vaccination

[eLife] Scientists determined the crystal structure of the globular head domain of canine distemper virus-hemagglutinin (CDV-H) vaccine strain at 3.2 Å resolution, revealing that CDV-H exhibited a highly tilted homodimeric form with a six-bladed β-propeller fold.