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lbeveridge
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Exosomal miR-129-2-3p Promotes Airway Epithelial Barrier Disruption in PM2.5-Aggravated Asthma
The authors investigated the role of exosomal miR-129-2-3p in regulating airway epithelial cell barrier function, its potential targets, and signaling pathways involved in PM2.5-induced aggravation of asthma. Abstract
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3D Cultivation of Non-Small-Cell Lung Cancer Cell Lines Using Four Different Methods
Four NSCLC cell lines, two adenocarcinomas and two squamous cell carcinomas, were first cultured in traditional 2D settings. Their expected expression profiles concerning TTF-1, CK7, CK5, and p40 status were confirmed...
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Activatable Near-Infrared Fluorescence Probe for Real-Time Imaging of PD-L1 Expression in Tumors
Investigators presented for the first time an activatable near-infrared fluorescence imaging probe for the real-time monitoring of PD-L1 expression in vitro and in vivo. The ability of Q-Atezol to detect PD-L1...
Cell Therapy News
Synergistic Effects of Human Umbilical Cord Mesenchymal Stem Cells/Neural Stem Cells and Epidural Electrical Stimulation on Spinal Cord Injury Rehabilitation
[Scientific Reports] Scientists examined neural stem cell changes via mRNA sequencing in an in vitro Transwell co-culture model. They then explored cell interaction mechanisms using proliferation assays, differentiation assays, and neuron complexity analysis.
Hematopoiesis News
Clonal Dynamics after Allogeneic Hematopoietic Cell Transplantation
[Nature] The authors quantified dynamics of long-term stem cell engraftment, the authors sequenced genomes from 2,824 single-cell-derived hematopoietic colonies of ten donor–recipient pairs taken 9–31 years after HLA-matched sibling HCT3.
Hematopoiesis News
FDA Grants Orphan Drug Designation to AND017 for the Treatment of Sickle Cell Disease
[Pharmacy Times] The FDA granted an orphan drug designation to AND017 for the treatment of sickle cell disease (SCD). The preclinical work that supports the ODD for AND017 in SCD will be presented in future scientific meetings and published in journals, according to experts.
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Inhibition of Stemness and PD-L1 Expression by Pien Tze Huang Enhances T Cell-Mediated Killing of Colorectal Cancer
[Journal of Ethnopharmacology] Investigators assessed the impact of Pien Tze Huang on colorectal cancer stem cells (CSCs), and evaluate the coordination effect of PZH on T cell-mediated anti-colorectal cancer with patient-derived autologous T cell co-culture.
Hydrogel PCDME Creates Pancreatic Cancer Stem Cells in OXPHOS Metabolic State with TXNIP Elevation
[Biochemical and Biophysical Research Communications] Researchers demonstrated that hydrogel PCDME could rapidly induce pancreatic cancer cell spheroids with elevated levels of stem cell markers including Sox2, Oct3/4, and Nanog, and the growth rate was reduced.
The Molecular Impact of miR-326 in Acute Lymphoblastic Leukemia and Its Cross Talk with P53
[Annals of Hematology] Scientists revealed that miR-326 exhibited a multifunctional anti-tumor behavior, affecting various aspects of drug resistance, stemness, and apoptosis in cancer, particularly in the context of acute lymphoblastic leukemia.