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lbeveridge

EVA1-Antibody Drug Conjugate Is a New Therapeutic Strategy for Eliminating Glioblastoma-Initiating Cells

[Neuro-Oncology] Hybridoma cells were generated by immunizing BALB/c mice with EVA1-Fc fusion protein. The reactivity of the supernatant from these hybridoma cells was examined using EVA1-overexpressing cells and glioblastoma-initiating cells. Candidate antibodies were further selected using Biacore surface plasmon resonance analysis and two cytotoxicity assays, antibody-dependent cell cytotoxicity and complement-dependent cytotoxicity

RAS-Mutant Leukemia Stem Cells Drive Clinical Resistance to Venetoclax

[Nature] Investigators provide the mechanistic explanation for this in a requirement for mutant RAS to specifically transform committed progenitors of the myelomonocytic lineage harboring previously acquired driver mutations, showing that advanced leukemic clones can originate from a different cell type in the hematopoietic hierarchy than ancestral clones.

High-Parametric Protein Maps Reveal the Spatial Organization in Early-Developing Human Lung

[FierceBiotech] Using high-parametric tissue imaging with a 30-plex antibody panel, investigators analyzed human lung samples from 6 to 13 post-conception weeks, generating data from over 2 million cells across five developmental timepoints.

MICU2 Up-Regulation Enhances Tumor Aggressiveness and Metabolic Reprogramming during Colorectal Cancer Development

[PLOS Biology] Scientists describe the role of MICU2 in cell proliferation and invasion using in vitro and in vivo models of human CRC. Transcriptomic analysis demonstrated an increase in MICU2 expression and the MICU2/MICU1 ratio in advanced CRC and CRC-derived metastases.

Single-Cell Transcriptomics of Rectal Organoids from Individuals with Perianal Fistulizing Crohn’s Disease Reveals Patient-Specific Signatures

[Scientific Reports] Rectal organoid and mucosal cells from endoscopic biopsies of each patient having perianal fistulizing CD or no disease controls were prepared for and sequenced at the single cell level.

Integrative Single-Cell Multi-Omics of CD19-CARpos and CARneg T Cells Suggest Drivers of Immunotherapy Response in B Cell Neoplasias

[Cell Reports Medicine] Investigators integrated clonal kinetics with transcriptomic heterogeneity resolved by single-cell omics to interrogate cellular dynamics of non-transduced and transduced T cells, in the infusion product and at the CAR-T cell expansion peak in five B cell acute lymphoblastic leukemia patients treated with CD19 CAR-T cells

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Inhibition of Stemness and PD-L1 Expression by Pien Tze Huang Enhances T Cell-Mediated Killing of Colorectal Cancer

[Journal of Ethnopharmacology] Investigators assessed the impact of Pien Tze Huang on colorectal cancer stem cells (CSCs), and evaluate the coordination effect of PZH on T cell-mediated anti-colorectal cancer with patient-derived autologous T cell co-culture.

Hydrogel PCDME Creates Pancreatic Cancer Stem Cells in OXPHOS Metabolic State with TXNIP Elevation

[Biochemical and Biophysical Research Communications] Researchers demonstrated that hydrogel PCDME could rapidly induce pancreatic cancer cell spheroids with elevated levels of stem cell markers including Sox2, Oct3/4, and Nanog, and the growth rate was reduced.

The Molecular Impact of miR-326 in Acute Lymphoblastic Leukemia and Its Cross Talk with P53

[Annals of Hematology] Scientists revealed that miR-326 exhibited a multifunctional anti-tumor behavior, affecting various aspects of drug resistance, stemness, and apoptosis in cancer, particularly in the context of acute lymphoblastic leukemia.