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Extracellular Matrix News

Resistance Training-Induced Changes in Muscle Proteolysis and Extracellular Matrix Remodeling Biomarkers in the Untrained and Trained States

[European Journal Of Applied Physiology] Scientists examined how proteolysis-related biomarkers and ECM remodeling factors respond to a bout of resistance training in the untrained and trained state.

Extracellular Matrix News

Sophoridine Exerts Anti-Arthritic Effects on Fibroblast-Like Synoviocytes and Collagen-Induced Arthritis in Rats

[Phytotherapy Research] A collagen-induced arthritis rat model and tumor necrosis factor alpha-induced fibroblast-like synoviocytes were utilized to investigate the inhibitory effect of Sophoridine on hreumatoid arthritis.

Extracellular Matrix News

Engineering Approaches for Understanding Mechanical Memory in Cancer Metastasis

[APL Bioengineering] Investigators explore the evolving mechanical landscape during metastasis, emphasizing the significance of mechanical memory and its influence on cell behavior.

Hepatic Cell News

DCDC2 Inhibits Hepatic Stellate Cell Activation and Ameliorates CCl4-Induced Liver Fibrosis by Suppressing Wnt/β-Catenin Signaling

[Scientific Reports] Investigators elucidated the role of doublecortin domain containing 2 (DCDC2) in liver fibrosis. Their findings revealed a reduction in DCDC2 expression in both human fibrotic liver tissues and carbon tetrachloride (CCl4)-induced mouse liver fibrotic tissues.

Mesenchymal Cell News

Defining Mesenchymal Stem/Stromal Cell-Induced Myeloid-Derived Suppressor Cells Using Single-Cell Transcriptomics

[Molecular Therapy] The authors revealed seven distinct immune cell types including myeloid-derived suppressor cells in the CD11bmidLy6Cmid cells, while CD11bhiLy6Chi cells included mostly monocytes/macrophages with a small cluster of neutrophils.

Mesenchymal Cell News

Transcriptomic and Cellular Decoding of Scaffolds-Induced Suture Mesenchyme Regeneration

[International Journal Of Oral Science] Investigators' data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.

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LSD1 Drives Intestinal Epithelial Maturation and Controls Small Intestinal Immune Cell Composition Independent of Microbiota in a Murine Model

Scientists showed that intestinal-epithelial intrinsic expression of lysine-specific demethylase 1A (LSD1) was necessary for the postnatal maturation of intestinal epithelium and maintenance of this developed state during adulthood. [Nature Communications] Full...

Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

[Cancer Research] To provide insights into the molecular mechanisms regulating IL1A expression in PDAC, researchers performed transcriptional profiling of The Cancer Genome Atlas datasets and pharmacologic screening in PDAC cells and identified p38α MAPK as a key positive regulator of IL1A expression.

From Stem Cells to Pancreatic β-Cells: Strategies, Applications, and Potential Treatments for Diabetes

[Molecular And Cellular Biochemistry] Scientists introduce the development of functional β-cells and their heterogeneity and then turn to highlight recent advances in the generation of β-cells from stem cells and their potential applications in disease modeling, drug discovery and clinical therapy.

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