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Pathophysiological Role of Ion Channels and Transporters in Hepatocellular Carcinoma

[Cancer Gene Therapy] Ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed.

Surface Nanocoating of Bacteria as a Versatile Platform to Develop Living Therapeutics

[Nature Protocols] The authors used interfacial self-assembly to prepare lipid membrane-coated bacteria, exhibiting increased resistance against a variety of harsh environmental conditions owing to the nanocoating’s protective capability.

Targeting Tumor-Associated Sialic Acids Using Chimeric Switch Receptors Based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells

[Cancer Immunology Research] Scientists reported that IFNγ, a potent immunomodulator secreted in the tumor microenvironment, can induce α2,6 hypersialylation in cancer cell lines derived from various histologies.

AURKB Promotes Immunogenicity and Immune Infiltration in Clear Cell Renal Cell Carcinoma

[Discover Oncology] Expression profiles and relevant clinical annotations were retrieved from the Cancer Genome Atlas and UCSC Xena platform for progression-free survival data. The R package "limma" was used to identify differentially expressed chromatin regulators.

Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing

[Circulation] Single-cell sequencing in peripheral blood mononuclear cells revealed a novel human-specific long noncoding RNA called HEAT4 (heart failure–associated transcript 4). HEAT4 expression was assessed in several in vitro and ex vivo models of immune cell activation, as well as in the blood of patients with heart failure, acute myocardial infarction, or cardiogenic shock.

ATM Inhibition Enhance Immunotherapy by Activating STING Signaling and Augmenting MHC Class I

[Cell Death & Disease] Investigators found that either gene knockout or drug intervention, ataxia telangiectasia mutated (ATM) inhibition activated the cGAS/STING pathway and augmented MHC class I in CRC cells, and these effects could be amplified by radiation.


Five Harvard Medical School Faculty Named HHMI Investigators

[Harvard Medical School] Five researchers from Harvard Medical School have been named among 26 new HHMI Investigators by the Howard Hughes Medical Institute (HHMI).

Shifts in Receptors during Submergence of an Encephalitic Arbovirus

[Nature] Investigators identified protocadherin 10 (PCDH10) as a cellular receptor for Western equine encephalitis virus (WEEV). They showed that multiple highly virulent ancestral WEEV strains isolated in the 1930s and 1940s, in addition to binding human PCDH10, could also bind very low-density lipoprotein receptor and apolipoprotein E receptor 2.

Glycan-Shielded Homodimer Structure and Dynamical Features of the Canine Distemper Virus Hemagglutinin Relevant for Viral Entry and Efficient Vaccination

[eLife] Scientists determined the crystal structure of the globular head domain of canine distemper virus-hemagglutinin (CDV-H) vaccine strain at 3.2 Å resolution, revealing that CDV-H exhibited a highly tilted homodimeric form with a six-bladed β-propeller fold.