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[Seminars in Diagnostic Pathology] Investigators discuss whether stem-ness enables metastasis or mutations drive metastasis. They ponder about low-grade versus high-grade tumors and about primary versus metastatic tumors.

[Nature Reviews Urology] New biological insights from these tumor microenvironments will enable rational design of strategies that co-target the tumor and stroma, which are expected to improve the outcomes of patients with advanced bladder cancer.

[Nature Metabolism] Scientists found that proline, a highly abundant amino acid in collagen proteins, was newly synthesized from glutamine in cancer-associated fibroblasts to make tumor collagen in breast cancer xenografts.

[Advanced Therapeutics] The authors showed that the direct injection of a hyaluronic acid-based microporous annealed particle hydrogel into the stroke core in mice reduces the percent of highly reactive astrocytes, increases the percent of alternatively activated microglia, decreases cerebral atrophy, and preserves NF200 axonal bundles.

[Medicinal Research Reviews] Investigators present the commonly used alternatives and latest advances in biofabrication of tumor-on-chips, which allow the generation of the most sophisticated and optimized models for recapitulating the tumor process.

[Cancer Discovery] Scientists performed integrative multi-omics analyses on tissues isolated before and after three months of androgen receptor-targeting enzalutamide monotherapy from high-risk prostate cancer patients enrolled in a neoadjuvant clinical trial.