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Quoin Pharmaceuticals Announces FDA Clearance of IND for its Lead Asset, QRX003, for Netherton Syndrome

[Quoin Pharmaceuticals, Inc.] Quoin Pharmaceuticals Ltd. announced that it has received FDA clearance to initiate clinical testing for its Investigational New Drug application for QRX003, the Company’s investigational product for Netherton Syndrome.

Sol-Gel Technologies and Galderma Announce FDA Approval of EPSOLAY®

[Sol-Gel Technologies Ltd.] Sol-Gel Technologies, Ltd. announced the FDA approval of its drug product, EPSOLAY®, a proprietary cream formulation of benzoyl peroxide, 5%, for the treatment of inflammatory lesions of rosacea in adults.

Sphingolipids Control Dermal Fibroblast Heterogeneity

[Science] Researchers found that the cell-to-cell variations of specific lipid metabolic pathways contribute to the establishment of cell states involved in the organization of skin architecture.

Weight-Bearing Activity Impairs Nuclear Membrane and Genome Integrity via YAP Activation in Plantar Melanoma

[Nature Communications] Scientists showed that the nuclear and micronuclear membranes of melanoma cells were frequently ruptured by macroscopic mechanical stress on the plantar surface due to weight-bearing activities.

Effect of the Most Common Wound Antiseptics on Human Skin Fibroblasts

[Clinical and Experimental Dermatology] Scientists determined the effects of hexetidine, povidone-iodine, undecylenamidopropyl-betaine/polyhexanide, chlorhexidine, disodium eosin, and hydrogen peroxide, on human skin fibroblasts.

Impact of Portuguese Propolis on Keratinocyte Proliferation, Migration and ROS Protection: Significance for Applications in Skin Products

[International Journal of Cosmetic Science] Researchers probed the action of Portuguese propolis extracts on skin cells, provided mechanistic insights into its mode of action and preliminarily assesed its applicability as a skin repair ingredient.

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Five Harvard Medical School Faculty Named HHMI Investigators

[Harvard Medical School] Five researchers from Harvard Medical School have been named among 26 new HHMI Investigators by the Howard Hughes Medical Institute (HHMI).

Shifts in Receptors during Submergence of an Encephalitic Arbovirus

[Nature] Investigators identified protocadherin 10 (PCDH10) as a cellular receptor for Western equine encephalitis virus (WEEV). They showed that multiple highly virulent ancestral WEEV strains isolated in the 1930s and 1940s, in addition to binding human PCDH10, could also bind very low-density lipoprotein receptor and apolipoprotein E receptor 2.

Glycan-Shielded Homodimer Structure and Dynamical Features of the Canine Distemper Virus Hemagglutinin Relevant for Viral Entry and Efficient Vaccination

[eLife] Scientists determined the crystal structure of the globular head domain of canine distemper virus-hemagglutinin (CDV-H) vaccine strain at 3.2 Å resolution, revealing that CDV-H exhibited a highly tilted homodimeric form with a six-bladed β-propeller fold.