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Noshin Noorjahan

Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification

[Cell Reports] Researchers delineated the dynamics of TFAP2C during the mouse peri-implantation stage and elucidated its collaboration with the key lineage regulators CDX2 and NANOG.

Neural Tracing Protein-Functionalized Nanoparticles Capable of Fast Retrograde Axonal Transport in Live Neurons

[Small] Microfluidics and two-photon confocal microscopy was applied to screen nanocarriers for transport efficacy and gain mechanistic insights into their interactions with neurons.

Discovery of Gefitinib-1,2, 3-Triazole Derivatives against Lung Cancer via Inducing Apoptosis and Inhibiting the Colony Formation

[Scientific Reports] A series of 20 novel gefitinib derivatives incorporating the 1,2,3-triazole moiety were designed and synthesized. The synthesized compounds were evaluated for their potential anticancer activity against epidermal growth factor receptor wild-type human NSCLC cells and human lung adenocarcinoma cells as NSCLC.

Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by Increasing ODC1 to Suppress Autophagy

[Journal Of Proteome Research] Investigators found that pirin was upregulated in NSCLC, and its expression was positively correlated with poor prognosis. Overexpression of pirin inhibited autophagy and promoted NSCLC proliferation.

Evasion of NKG2D-Mediated Cytotoxic Immunity by Sarbecoviruses

[Cell] Researchers found that SARS-CoV-2 evaded NKG2D recognition by surface downregulation of MIC-A/B via shedding, observed in human lung tissue and COVID-19 patient serum.

The Role of Extracellular Vesicles in the Treatment of Prostate Cancer

[Small] The authors discuss the recent advancements in the application of extracellular vesicle (EV) therapies and highlight EV-based functional materials as novel interventions for prostate cancer.

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Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity

[Nature Communications] The authors showed that the hyperactivation of Janus kinase 2 by the V617F mutation phosphorylated tyrosine residues in coactivator-associated arginine methyltransferase 1 (CARM1), an important target in hematologic malignancies, increasing its methyltransferase activity and altering its target specificity.

Clinical Associations with a Polygenic Predisposition to Benign Lower White Blood Cell Counts

[Nature Communications] Researchers investigated the clinical consequences of a genetic predisposition toward lower white blood cell (WBC) counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count comprising single nucleotide polymorphisms not associated with disease.

SUCLG1 Restricts POLRMT Succinylation to Enhance Mitochondrial Biogenesis and Leukemia Progression

[EMBO Journal] Investigators reported that expression of tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlated with electron transport chain genes across various TCGA cancer transcriptomes.