All Articles by Author:

Noshin Noorjahan

SMCHD1 Activates the Expression of Genes Required for the Expansion of Human Myoblasts

[Nucleic Acids Research] Genomic and transcriptomic experiments determined that structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) associated with enhancers of genes controlling cell cycle to activate their expression.

METAPHOR: Metabolic Evaluation through Phasor-Based Hyperspectral Imaging and Organelle Recognition for Mouse Blastocysts and Oocytes

[Proceedings of The National Academy of Sciences of The United States of America] Metabolic Evaluation through Phasor-based Hyperspectral Imaging and Organelle Recognition (METAPHOR) is a non-invasive, label-free imaging method thaT combined two-photon illumination and AI to deliver the metabolic profile of embryos and oocytes based on intrinsic autofluorescence signals.

Intracellular Domain of Epithelial Cell Adhesion Molecule Induces Wnt Receptor Transcription to Promote Colorectal Cancer Progression

[Journal of Biomedical Science] Scientists used patient-derived organoids and xenografts, and various colorectal cancer cell lines were used to study the roles of epithelial cell adhesion molecule and its intracellular domains in Wnt receptor expression.

Tumor Evolution Metrics Predict Recurrence beyond 10 Years in Locally Advanced Prostate Cancer

[Nature Cancer] The authors mapped genomic intratumor heterogeneity in locally advanced prostate cancer using 642 samples from 114 individuals enrolled in clinical trials with a 12-year median follow-up.

Human Yolk Sac-Derived Innate Lymphoid-Biased Multipotent Progenitors Emerge Prior to Hematopoietic Stem Cell Formation

[Developmental Cell] Scientists demonstrated the presence of human yolk sac-derived lymphoid-biased progenitors expressing CD34, IL7R, LTB, and IRF8 at Carnegie stage 10, much earlier than the first HSC emergence.

Endomucin Marks Quiescent Long-Term Multi-lineage Repopulating Hematopoietic Stem Cells and Is Essential for Their Transendothelial Migration

[Cell Reports] Cell cycle analyses and transcriptional profiling demonstrated that endomucin (EMCN)+ long-term repopulating HSCs (LT-HSCs) were more quiescent compared to EMCN LT-HSCs.

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Efficacy of Stem Cells Versus Microvesicles in Ameliorating Chronic Renal Injury in Rats (Histological and Biochemical Study)

[Scientific Reports] Scientists evaluated the therapeutic potential of adipose tissue-derived stem cells in comparison to their microvesicles in aluminum chloride-induced chronic renal injury.

Evaluating [225Ac]Ac-FAPI-46 for the Treatment of Soft-Tissue Sarcoma in Mice

[European Journal of Nuclear Medicine and Molecular Imaging] The authors investigated the anti-tumor efficacy of [225Ac]Ac-FAPI-46 as monotherapy or in combination with immune checkpoint blockade (ICB) in immunocompetent murine models of sarcoma sensitive or resistant to ICB.

Production and Performance Evaluation of Chitosan/Collagen/Honey Nanofibrous Membranes for Wound Dressing Applications

[International Journal of Biological Macromolecules] Scientists formulated mixtures of polyvinyl alcohol, chitosan, collagen, and honey to produce nanofibrous membranes with healing properties.