Noshin Noorjahan

Extracellular Matrix News

LIMK2 Inactivation Suppresses Mechanical Stimulation-Induced Dermal Fibroblast Differentiation and Resistance to Apoptosis

[Scientific Reports] Researchers investigated the role of LIMK2, a component of the Rho/ROCK/LIMK/cofilin pathway, in cell differentiation and apoptosis in response to mechanical stimulation and proliferation in human dermal fibroblasts.

Extracellular Matrix News

An Update on the Landscape of Collagen Bioactive Fragments

[FEBS Journal] Investigators provide an overview of the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and pathological contexts affecting heart, lung, adipose, and even brain tissues.

Extracellular Matrix News

Cell Adhesion Molecules As Emerging Regulators of Ferroptosis: Mechanisms and Therapeutic Opportunities in Cancer

[Apoptosis] The authors offer a systematic summary of the roles played by major cell adhesion molecules families—namely, the immunoglobulin superfamily, cadherins, and integrins—in the regulation of ferroptosis.

Extracellular Matrix News

FibroBiologics Announces Issuance of Canadian Patent Covering Novel Fibroblast-Based Treatment for Cachexia

[FibroBiologics, Inc.] FibroBiologics, Inc. announced that the Canadian Intellectual Property Office has issued Canadian Patent No. 3118732, titled “Treatment of Cachexia Using Fibroblast Cells and Products Thereof.”

Endothelial Cell News

Human Subcutaneous Derived Stromal Vascular Fraction Endothelial Cells Display Venous and Arterial Markers in Culture and 3D Capillaries

[Tissue Engineering and Regenerative Medicine] Researchers investigated endothelial cells from the stromal vascular fraction of human subcutaneous white adipose tissue in 2D culture and 3D bioengineered skin models to better define their specific subtypes.

Endothelial Cell News

Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells, and Impairs Late Cortical Angiogenesis

[Journal of Neurochemistry] Scientists investigated whether ethanol-induced effects on endothelial cells involve epigenetic reprogramming, specifically through alterations in DNA methylation profiles.

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GentiBio Secures NIH Backing for Allogeneic Engineered Treg Therapy in Type 1 Diabetes

[GentiBio, Inc. (AllSci)] GentiBio, Inc. has received a USD 1.07 million NIH Phase II grant from the National Institute of Diabetes and Digestive and Kidney Diseases to advance an allogeneic, off-the-shelf engineered Treg therapy for newly diagnosed type 1 diabetes. q

CD4+CD25+FOXP3+ Regulatory T Cells to Protect against Graft-Versus-Host Disease

[Blood] The authors discuss the history, preclinical studies, and successful translation of CD4+CD25+FoxP3+ Tregs in the context of allogeneic hematopoietic cell transplantation.

UV Irradiation Drives Lineage-Specific MITF-Mediated Transcription of PD-L1 to Confer Immune Tolerance to UV-Mutated Melanocytes

[Immunity] Researchers investigated whether melanocyte-intrinsic transcriptional program(s) underlie immune tolerance to mutations resulting from UV radiation exposure.

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Noshin Noorjahan

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