Noshin Noorjahan

Intestinal Cell News

Crosstalk between Colorectal Cancer Cells and Cancer-Associated Fibroblasts in the Tumor Microenvironment Mediated by Exosomal Noncoding RNAs

[Frontiers in Immunology] The authors review the current status and progress of research on cancer-associated fibroblastss-derived exosomal non-coding RNAs in colorectal cancer.

Intestinal Cell News

Insight into Immune Checkpoint Inhibitor Therapy for Colorectal Cancer from the Perspective of Circadian Clocks

[Immunology] Scientists highlight the crosstalk between the tumor immune microenvironment in colorectal cancer (CRC) and the immunogenicity of CRC cells based on the circadian clocks.

Intestinal Cell News

$8.7M USD for World’s Largest Colorectal Cancer Registry

[University of Melbourne] The international registry of colorectal cancer patients and relatives, supporting earlier diagnosis and research to improve patient outcomes, has received $8.7 million USD from the US National Institutes of Health.

Mammary Cell News

Combination of Novel Oncolytic Herpesvirus with Paclitaxel as an Efficient Strategy for Breast Cancer Therapy

[Journal of Medical Virology] The antitumor effect of VG161 and paclitaxel was confirmed in a breast cancer xenograft mouse model.

Mammary Cell News

Dependency of NELF-E-SLUG-KAT2B Epigenetic Axis in Breast Cancer Carcinogenesis

[Nature Communications] Using cancer cell lines and patient-derived tumor organoids, scientists demonstrated that loss of the negative elongation factor (NELF) complex inhibited breast cancer development through downregulating epithelial-mesenchymal transition and stemness-associated genes.

Mammary Cell News

Macrophages Maintain Mammary Stem Cell Activity and Mammary Homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 Axis

[npj Regenerative Medicine] Investigators showed that mammary resident macrophages regulated mammary epithelium cell division and mammary development through TNF-α-Cdk1/Cyclin B1 axis.

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Atorvastatin Calcium Alleviates UVB-Induced HaCat Cell Senescence and Skin Photoaging

[Scientific Reports] Through in vitro experiments with human immortalized keratinocytes (HaCat), researchers found that atorvastatin calcium could significantly reduce the ultraviolet radiation B-induced increased expression of age-related protein p16 and age-related gene p21, and also reduce the up-regulation of inflammatory factors such as IL-1 and IL-6.

Dysregulation in Keratinocytes Drives Systemic Lupus Erythematosus Onset

[Cellular & Molecular Immunology] Investigators found that the level of peroxisome proliferator-activated receptor gamma was substantially reduced in the skin lesions of patients, and replicating this reduction in mice led to rapid disease onset with multiple hallmarks of systemic lupus erythematosus.

USP19 Potentiates Autophagic Cell Death via Inhibiting mTOR Pathway through Deubiquitinating NEK9 in Pancreatic Cancer

[Cell Death & Differentiation] Scientists identified that ubiquitin-specific protease 19 (USP19) was downregulated in pancreatic tumor tissues and forced expression of USP19 diminished tumorigenicity of pancreatic cancer.

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Noshin Noorjahan

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