All Articles by Author:

Noshin Noorjahan

Biomarkers of Alveolar Epithelial Injury and Endothelial Dysfunction Are Associated with Scores of Pulmonary Edema in Invasively Ventilated Patients

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Plasma levels of surfactant protein-D, soluble receptor for advanced glycation end products, and angiopoietin-2 (Ang-2) were measured in a prospective, multicenter cohort of invasively ventilated patients.

Intraprocedural Endothelial Cell Seeding of Arterial Stents via Biotin/Avidin Targeting Mitigates In-Stent Restenosis

[Scientific Reports] Investigators reported on the novel stent endothelialization strategy of post-deployment seeding of biotin-modified endothelial cells to avidin-functionalized stents.

Paricalcitol Protects against Hydrogen Peroxide-Induced Injury in Endothelial Cells through Suppression of Apoptosis

[Experimental Biology and Medicine] Scientists investigated the restorative and protective potentials of paricalcitol, a vitamin D analogue, which was frequently used in patients with chronic renal failure in human umbilical vein endothelial cells before and after H2O2-induced oxidative stress.

Diabetic Retinopathy and Corneal Endothelial Parameters: An Analytical Cross-Sectional Study

[BMC Ophthalmology] In this descriptive-analytical cross-sectional study, corneal endothelium parameters including endothelial cell density, average cell size, coefficient of variation in cell size, and hexagonality were evaluated by non-contact specular microscopy.

Role of Anti-Vascular Endothelial Growth Factor in the Management of Non-Proliferative Diabetic Retinopathy without Center-Involving Diabetic Macular Edema: A Meta-Analysis of Trials

[Eye] The authors reviewed the impact of anti-vascular endothelial growth factor treatment in management of eyes with non-proliferative diabetic retinopathy without center involving diabetic macular edema.

Contego Medical Completes Enrollment of the PERFORMANCE II Carotid Stent Trial

[Contego Medical, Inc.] Contego Medical, Inc. announced that enrollment of the PERFORMANCE II clinical trial had been completed. PERFORMANCE II was designed to evaluate the safety and effectiveness of the Neuroguard IEP® 3-in-1 Carotid Stent and Post-Dilation Balloon System with Integrated Embolic Protection.

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Truqap Plus Faslodex Approved in the EU for Patients with Advanced ER-Positive Breast Cancer

[AstraZeneca] AstraZeneca’s Truqap (capivasertib) in combination with Faslodex (fulvestrant) has been approved in the European Union (EU) for the treatment of adult patients with ER-positive, HER2‑negative locally advanced or metastatic breast cancer with one or more PIK3CA, AKT1, or PTEN-alterations following recurrence or progression on or after an endocrine-based regimen.

Breast Cancer Exploits Neural Signaling Pathways for Bone-to-Meninges Metastasis

[Science] Scientists applied a combination of intravital and ex vivo three-dimensional confocal microscopy, micro–computed tomography, and histologic analyses to mouse models of bone-metastatic breast cancer and leptomeninges (LM) metastasis,. They demonstrated that breast cancer cells could traffic to the LM from the bone marrow through abluminal emissary vein migration.

RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis

[Cancer Research] Investigators employed a CRISPR/Cas9 screening strategy that revealed RUVBL1 and RUVBL2 as putative targets. Loss of RUVBL1/2 preferentially impaired the growth of YTHDF1-high colorectal cancer (CRC) cells, patient-derived primary CRC organoids, and subcutaneous xenografts.