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Noshin Noorjahan

Extracellular Vesicles Engineering by Silicates-Activated Endothelial Progenitor Cells for Myocardial Infarction Treatment in Male Mice

[Nature Communications] The authors demonstrated a biomaterial-based approach to prepare high amounts of extracellular vesicles with high bioactivity from endothelial progenitor cells by stimulation with silicate ions derived from bioactive silicate ceramics.

Molecular Profiling of the Stroke-Induced Alterations in the Cerebral Microvasculature Reveals Promising Therapeutic Candidates

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists elucidated the stroke-induced transcriptomic changes in the mouse cerebral microvasculature and compared them with the alterations observed in human brain stroke lesions.

SCAP Contributes to Embryonic Angiogenesis by Negatively Regulating KISS-1 Expression in Mice

[Cell Death & Disease] Investigators reported for the first time that vascular smooth muscle cell (VSMC)-specific ablation of sterol regulatory element-binding protein cleavage-activating protein (SCAP) inhibited VSMC proliferation and migration, interacting with endothelial cells, and finally caused defective embryonic angiogenesis in mice.

Endothelial ACKR1 Is Induced by Neutrophil Contact and Down-Regulated by Secretion in Extracellular Vesicles

[Frontiers In Immunology] The authors reported that exposure to whole blood induced atypical chemokine receptor-1 (ACKR1) mRNA and protein expression in cultured primary human lung microvascular endothelial cells.

Mechanosensitive mTORC1 Signaling Maintains Lymphatic Valves

[Journal of Cell Biology] Researchers investigated the dynamics and the molecular mechanisms of lymphatic endothelial cell renewal in adult mesenteric quiescent lymphatic vasculature using label-retention, lineage tracing, and cell ablation strategies.

Piezo1 Induces Endothelial Responses to Shear Stress via Soluble Adenylyl Cyclase-IP3R2 Circuit

[iScience] Scientists showed that activation of the mechanosensitive channel Piezo1 by defined shear forces induced Ca2+ entry into the endoplasmic reticulum (ER) via the ER Ca2+ ATPase pump.

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NOR-1 Overexpression Elevates Myoglobin Expression via PERM1 and Enhances Mitochondrial Function and Endurance in Skeletal Muscles of Aged Mice

[FASEB Journal] Transcriptomic profiling of the human response to exercise revealed that the nuclear receptor NR4A3 (NOR-1) was among the most responsive genes to acute exercise.

One-Step Laser-Assisted Electrohydrodynamic Printing of Microelectronic Scaffolds for Electrophysiological Monitoring of Aligned Cardiomyocytes

[ACS Nano ] A laser-assisted electrohydrodynamic printing strategy was proposed to directly fabricate a microfibrous architecture with built-in microelectronics for electrophysiological monitoring of aligned cardiomyocytes.

Sarcopenia and Skeletal Muscle Loss after CAR T-cell Therapy in Diffuse Large B cell Lymphoma

[Clinical Cancer Research] In 83 large B-cell lymphoma patients, the skeletal muscle index was measured from clinical images obtained at baseline and days 30 and 90 post-therapy.