All Articles by Author:
Noshin Noorjahan
Endothelial Cell News
Aulos Bioscience Announces FDA Clearance of IND Application for AU-007, a Novel Immunotherapy for the Treatment of Solid Tumors
[Aulos Bioscience] Aulos Bioscience announced that the US FDA has cleared its Investigational New Drug application for AU-007, a monoclonal antibody computationally designed by Biolojic Design.
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Arglabin, an EGFR Receptor Tyrosine Kinase Inhibitor, Suppresses Proliferation and Induces Apoptosis in Prostate Cancer Cells
[Biomedicine & Pharmacotherapy] Arglabin, a sesquiterpene lactone isolated from Artemisia glabella, was cytotoxic to different human cancer cell lines including those derived from advanced triple-negative breast, lung, and androgen-dependent and androgen-independent prostate carcinomas.
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A Cryptic Transactivation Domain of EZH2 Binds AR and AR’s Splice Variant, Promoting Oncogene Activation, and Tumorous Transformation
[Nucleic Acids Research] Scientists reported that a cryptic transactivation domain of EZH2 binds both androgen receptor (AR) and AR spliced variant 7 mediating assembly and/or recruitment of transactivation-related machineries at genomic sites that lack polycomb repressive complex 2 binding.
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PSMA1-Mediated Ultrasmall Gold Nanoparticles Facilitate Tumor Targeting and MR/CT/NIRF Multimodal Detection of Early-Stage Prostate Cancer
[Nanomedicine: Nanotechnology, Biology and Medicine] Investigators devised a multimodal contrast agent that featured highly-effective PSMA targeting and desired molecular pharmacokinetics for prostate cancer diagnosis.
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Knockdown of USP8 Inhibits Prostate Cancer Cell Growth, Proliferation, and Metastasis and Promotes Docetaxel’s Activity by Suppressing the NF-kB Signaling Pathway
[Frontiers in Oncology] Prostate cancer cell lines DU145 and PC3 were transfected with ubiquitin-specific protease 8 siRNA or overexpressing vector together with or without docetaxel.
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Juglone Promotes Antitumor Activity against Prostate Cancer via Suppressing Glycolysis and Oxidative Phosphorylation
[Phytotherapy Research] Researchers investigated the effect of juglone on energy metabolism in prostate cancer cells and found that juglone inhibited cell proliferation and induced apoptosis.
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Innate Immune Cell Functions Contribute to Spontaneous HIV Control
[Current HIV/Aids Reports] The authors review the role of innate immune cells in shaping the viral reservoir and maintenance of long-term viral control of spontaneous Elite and Viremic HIV controllers.
Dyadic Receives $3 Million Grant to Develop Cost-Effective Monoclonal Antibodies for RSV and Malaria Using C1 Platform Technology
[Dyadic International, Inc.] Dyadic International, Inc. announced that it has been awarded a $3 million grant from the Gates Foundation for the cell line development of monoclonal antibodies targeting respiratory syncytial virus (RSV) and malaria utilizing the company’s proprietary C1 protein production platform to provide globally accessible treatment options for underserved populations.
CAR-T Cell Therapy: Challenge and Opportunity for Effective Treatment of Small Cell Lung Cancer
[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists characterized the biological signature of small cell lung cancer and outline the obstacles to current treatment, including impaired antigen presentation and T cell infiltration.