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Noshin Noorjahan

Opposing Roles for ADAMTS2 and ADAMTS14 in Myofibroblast Differentiation and Function

[Journal Of Pathology] Scientists highlighted stellate-specific expression of transcripts encoding the collagen-processing enzymes ADAMTS2 and ADAMTS14.

3D Printed Magneto-Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Models

[Small] The authors reported the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting of a magnetized polycaprolactone-based composite.

Enhanced SARS-CoV-2 Humoral Immunity Following Breakthrough Infection Builds upon the Preexisting Memory B Cell Pool

[Science Immunology] To investigate how B cells respond to repeated SARS-CoV-2 antigen exposure by Wu01 booster vaccination and Omicron breakthrough infection, the authors performed a molecular longitudinal analysis of the memory B cell pool.

Leukotriene A4 Hydrolase Inhibition Improves Age-Related Cognitive Decline via Modulation of Synaptic Function

[Science Advances] Scientists identified that the enzyme leukotriene A4 hydrolase (LTA4H) was expressed in healthy mouse neurons, and inhibition of LTA4H in aged mice improved hippocampal dependent memory.

A Tool Kit of Highly Selective and Sensitive Genetically Encoded Neuropeptide Sensors

[Science] To permit the fast and scalable development of neuropeptide sensors, we have developed an ICL3 grafting method that efficiently generates genetically encoded fluorescent sensors.

Mitigating Aberrant Cdk5 Activation Alleviates Mitochondrial Defects and Motor Neuron Disease Symptoms in Spinal Muscular Atrophy

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors reported that the activity of cyclin-dependent kinase 5 (Cdk5) and the conversion of its activating subunit p35 to the more potent activator p25 were significantly up-regulated in mouse models and human induced pluripotent stem cell models of spinal muscular atrophy.

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CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia

[New England Journal of Medicine] Investigators enrolled patients from a compassionate-use program and those from a Phase I study who had primary multirefractory autoimmune hemolytic anemia. Each patient received a single infusion of autologous CD19 CAR T cells.

CD4+ T Cells Mediate CAR-T Cell-Associated Immune-Related Adverse Events after BCMA CAR-T Cell Therapy

[Nature Medicine] Among 198 patients treated with ciltacabtagene autoleucel or idecabtagene vicleucel, 27 developed CAR T cell therapy-associated immune-related adverse events (CirAEs). This included one remarkable case with three distinct CirAEs in association with an extreme CD4+ CAR T cell expansion.

Contaminating Plasmid Sequences and Disrupted Vector Genomes in the Liver following Adeno-Associated Virus Gene Therapy

[Nature Medicine] Scientists conducted a case study of a child with spinal muscular atrophy type 1 experiencing substantial hepatitis after receiving onasemnogene abeparvovec, undertaking long- and short-read metagenomic sequencing of liver tissue.