[Journal Of Pathology] Scientists highlighted stellate-specific expression of transcripts encoding the collagen-processing enzymes ADAMTS2 and ADAMTS14.
[Small] The authors reported the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting of a magnetized polycaprolactone-based composite.
[Science Immunology] To investigate how B cells respond to repeated SARS-CoV-2 antigen exposure by Wu01 booster vaccination and Omicron breakthrough infection, the authors performed a molecular longitudinal analysis of the memory B cell pool.
[Science Advances] Scientists identified that the enzyme leukotriene A4 hydrolase (LTA4H) was expressed in healthy mouse neurons, and inhibition of LTA4H in aged mice improved hippocampal dependent memory.
[Science] To permit the fast and scalable development of neuropeptide sensors, we have developed an ICL3 grafting method that efficiently generates genetically encoded fluorescent sensors.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors reported that the activity of cyclin-dependent kinase 5 (Cdk5) and the conversion of its activating subunit p35 to the more potent activator p25 were significantly up-regulated in mouse models and human induced pluripotent stem cell models of spinal muscular atrophy.
[New England Journal of Medicine] Investigators enrolled patients from a compassionate-use program and those from a Phase I study who had primary multirefractory autoimmune hemolytic anemia. Each patient received a single infusion of autologous CD19 CAR T cells.
[Nature Medicine] Among 198 patients treated with ciltacabtagene autoleucel or idecabtagene vicleucel, 27 developed CAR T cell therapy-associated immune-related adverse events (CirAEs). This included one remarkable case with three distinct CirAEs in association with an extreme CD4+ CAR T cell expansion.
[Nature Medicine] Scientists conducted a case study of a child with spinal muscular atrophy type 1 experiencing substantial hepatitis after receiving onasemnogene abeparvovec, undertaking long- and short-read metagenomic sequencing of liver tissue.