Noshin Noorjahan

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Microbiota-Derived Butyrate Dampens Linaclotide Stimulation of the Guanylate Cyclase C Pathway in Patient-Derived Colonoids

[Neurogastroenterology And Motility] Human-derived intestinal organoids were grown from pediatric disorders of gut-brain interaction and non-IBD colon biopsies. Colonoids were treated with 250 nM linaclotide and assayed for cGMP to develop a model of guanylin cyclase C activity.

Newsletters

Lung Cancer Organoids: Models for Preclinical Research and Precision Medicine

[Frontiers in Oncology] The authors present a comprehensive review on the construction methods and potential applications of lung cancer organoids in both preclinical and clinical research.

Hepatic Cell News

Interaction between Estrogen Receptor-α and PNPLA3 p.I148M Variant Drives Fatty Liver Disease Susceptibility in Women

[Nature Medicine] Scientists showed that there was a specific multiplicative interaction between female sex and PNPLA3 p.I148M in determining fatty liver disease in at-risk individuals (steatosis and fibrosis, and advanced fibrosis/hepatocellular carcinoma) and in the general population.

Hepatic Cell News

Combined FOLFOX4 with All-Trans Retinoic Acid Versus FOLFOX4 with Placebo in Treatment of Advanced Hepatocellular Carcinoma with Extrahepatic Metastasis: A Randomized, Double-Blind Comparative Study

[Signal Transduction and Targeted Therapy] In this randomized, double-blind, placebo-controlled study, investigators assessed the efficacy and safety of FOLFOX4 with all-trans-retinoic acid as a palliative treatment for HCC patients with extrahepatic metastasis, compared to FOLFOX4 with a placebo.

Hepatic Cell News

Long-Term Major Adverse Liver Outcomes in 1,260 Patients with Non-Cirrhotic NAFLD

[JHEP Reports] Researchers conducted a cohort study with data from Swedish university hospitals. Patients with nonalcoholic fatty liver disease (NAFLD) without cirrhosis were diagnosed through biopsy or radiology, and had fibrosis estimated.

Hepatic Cell News

MAD2 Activates IGF1R/PI3K/AKT Pathway and Promotes Cholangiocarcinoma Progression by Interfering USP44/LIMA1 Complex

[Oncogene] Investigators found up-regulated mitotic arrest deficient 2 (MAD2) facilitated cholangiocarcinoma progression and induced lymphatic metastasis dependent on USP44/LIMA1/PI3K/AKT pathway.

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Unmasking Cancer’s Silent Saboteurs: T Regulatory Cells As Therapeutic Targets in Immunotherapy

[Expert Review of Clinical Immunology] Scientists explore the role of Tregs in the immune system, delve into their contribution to cancer and tumor progression, and highlight therapeutic strategies targeting Tregs, along with innovative delivery systems.

Destruction of VISTA by TRIM25 Ablation in T Cells Potentiates Cancer Immunotherapy

[Cell Research] Researchers unveiled a mechanism for V-domain Ig suppressor of T cell activation (VISTA) regulation in T cells and highlights targeting tripartite motif containing 25 (TRIM25)–VISTA as a potential strategy to enhance tumor immunotherapy.

The IL-1R and NFKBIZ Pathway Mediates Immunoregulatory Responses and Immunotherapy Efficacy in Anaplastic Large Cell Lymphoma

[Leukemia] The authors conducted integrated genome-wide CRISPR-Cas9 loss-of-function screens using CD30-specific CAR-engineered NK cells, alongside a complementary PD-L1 regulator screen, and uncovered a critical role for interleukin-1 receptor signaling in modulating CAR therapy efficacy in both ALK^⁺ and ALK^⁻ anaplastic large cell lymphoma.

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