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Reduced Adhesion of Aged Intestinal Stem Cells Contributes to an Accelerated Clonal Drift

[Life Science Alliance] Tracking of clonal dynamics by clonal tracing revealed that aged crypts drift into monoclonality substantially faster than young ones.

Surrozen Initiates Dosing in Phase I Clinical Trial of SZN-1326 for Moderate to Severe Ulcerative Colitis

[Surrozen, Inc.] Surrozen, Inc. announced that the first subject has been dosed in its three-part Phase I clinical trial to evaluate SZN-1326 for the potential treatment of moderate to severe ulcerative colitis.

RNA Splicing Is a Key Mediator of Tumour Cell Plasticity and a Therapeutic Vulnerability in Colorectal Cancer

[Nature Communications] The authors identified dysregulated RNA splicing as a key driver of tumour cell dedifferentiation in colorectal cancer.