Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

LAPTM4B-Mediated Hepatocellular Carcinoma Stem Cell Proliferation and MDSC Migration: Implications for HCC Progression and Sensitivity to PD-L1 Monoclonal Antibody Therapy

[Cell Death & Disease] Scientists' mechanistic investigations identified lysosomal-associated transmembrane protein 4B (LAPTM4B) as a crucial gene regulated by ETV1, especially in liver cancer stem cells.

A Tumor Suppressor Protein Encoded by circKEAP1 Inhibits Osteosarcoma Cell Stemness and Metastasis by Promoting Vimentin Proteasome Degradation and Activating Anti-Tumor Immunity

[Journal of Experimental & Clinical Cancer Research] Microarray analysis was performed to identify circRNAs that were differentially-expressed between osteosarcoma and corresponding normal tissues.

Identification of Subtypes in Triple-Negative Breast Cancer Based on Shared Genes Between Immunity and Cancer Stemness

[Journal Of Immunotherapy] Researchers investigated the correlation of immunity and cancer stemness with the molecular subtyping and survival rates in triple negative breast cancer using bioinformatics approaches.

Discovery of Novel N-(Anthracen-9-ylmethyl) Benzamide Derivatives as ZNF207 Inhibitors Promising in Treating Glioma

[Journal Of Medicinal Chemistry] A series of novel N-(anthracen-9-ylmethyl) benzamide derivatives against ZNF207 were rationally designed and synthesized. The inhibitory activity was evaluated, and their structure–activity relationships were summarized.

Cellular Hierarchy Insights Reveal Leukemic Stem-Like Cells and Early Death Risk in Acute Promyelocytic Leukemia

[Nature Communications] Researchers unveiled a cellular differentiation hierarchy within acute promyelocytic leukemia blasts, rooted in leukemic stem-like cells.

Methionine Secreted by Tumor-Associated Pericytes Supports Cancer Stem Cells in Clear Cell Renal Carcinoma

[Cell Metabolism] Scientists identified a subset of vascular pericytes that promoted tumorigenesis and tyrosine kinase inhibitors resistance by functioning as the primary methionine source for CSCs in clear cell renal cell carcinoma.

Revealing Role of Epigenetic Modifiers and DNA Oxidation in Cell-Autonomous Regulation of Cancer Stem Cells

[Cell Communication and Signaling] Researchers used pharmacological inhibitor of H3K4, knockdown of KMT2B or KMT2D in breast cancer cells, real time PCR, response to chemotherapy, flow cytometry, and more for circulating markers of CSCs and DNA hydroxylases in breast cancer patients.

Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells

[Stem Cell Reviews And Reports] Circulating tumor cells exhibit molecular diversity and stem-like and mesenchymal features, even when derived from primary tumor tissue from a single patient.

NIH Launches Research Network to Evaluate Emerging Cancer Screening Technologies

[National Institutes of Health] The National Institutes of Health (NIH) has launched a clinical trials network to evaluate emerging technologies for cancer screening.

Iovance’s AMTAGVI™ (lifileucel) Receives US FDA Accelerated Approval for Advanced Melanoma

Iovance Biotherapeutics, Inc. announced that the US FDA has approved AMTAGVI™ suspension for intravenous infusion. [nan] Press Release

FBP1 Inhibits NSCLC Stemness by Promoting Ubiquitination of Notch1 Intracellular Domain and Accelerating Degradation

[Cellular And Molecular Life Sciences] Scientists showed that overexpression of fructose-1,6-bisphosphatase 1 (FBP1), a gluconeogenic enzyme, functions as a tumor suppressor to regulate the stemness of NSC led to a decrease in the proportion of CD133-positive cells, weakened tumorigenicity, and decreased expression of stemness factors.

The Dopamine Transporter Antagonist Vanoxerine Inhibits G9a and Suppresses Cancer Stem Cell Functions in Colon Tumors

[Nature Cancer] Using a stem cell-based phenotypic drug-screening pipeline, the authors identified the dopamine transporter antagonist vanoxerine, a compound with previously demonstrated clinical safety, as a cancer-specific downregulator of G9a expression.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.