MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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M6A RNA Methylation-Mediated RMRP Stability Renders Proliferation and Progression of Non-Small Cell Lung Cancer through Regulating TGFBR1/SMAD2/SMAD3 Pathway

Based on an integrative analysis of The Cancer Genome Atlas database, investigators identified long non-coding RNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that are associated with poor survival in non-small cell lung cancer.
[Cell Death & Differentiation]
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Circulating Cell-Free DNA Yield and Circulating-Tumor DNA Quantity from Liquid Biopsies of 12 139 Cancer Patients

Investigators examined the impact of patient age, sex, stage, and tumor type on circulating-free DNA yield, circulating-tumor DNA fraction, and estimated ctDNA quantity from a large cohort of clinical liquid biopsy samples.
[Clinical Chemistry]
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Oncogenic Role of SOX9-DHCR24-Cholesterol Biosynthesis Axis in IGH-BCL2 Positive Diffuse Large B-Cell Lymphomas

Silencing of SOX9 decreased cell proliferation, induced G1/S arrest and increased apoptosis of diffuse large B-cell lymphoma cells, both in vitro and in vivo.
[Blood]
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Hypoxia Effects on Cancer Stem Cell Phenotype in Colorectal Cancer: A Mini-Review

Scientists discuss CSC molecular regulation, signaling pathways, methods for the study of the topic, as well as molecules and drugs capacity of inhibiting the interplay of hypoxia-CSC.
[Molecular Biology Reports]
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Lixte Biotechnology Announces Collaboration with Netherlands Cancer Institute (Amsterdam) and Oncode Institute (Utrecht) to Identify the Most Promising Drug Combinations for its Lead Clinical Compound, LB-100, for Cancer Treatment

Lixte Biotechnology Holdings, Inc. announced entry into a collaboration with the Netherlands Cancer Institute, Amsterdam, and Oncode Institute, Utrecht to identify the most promising drugs to be combined with LB-100, and potentially LB-100 analogues, to be used to treat a range of cancers, as well as to identify the specific molecular mechanisms underlying the identified combinations.
[Lixte Biotechnology Holdings, Inc.]
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SNAIL2 Contributes to Tumorigenicity and Chemotherapy Resistance in Pancreatic Cancer by Regulating IGFBP2

Scientists showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro and in vivo in two pancreatic cancer cell lines, KLM1 and KMP5.
[Cancer Science]
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Targeting EYA2 Tyrosine Phosphatase Activity in Glioblastoma Stem Cells Induces Mitotic Catastrophe

The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.
[Journal of Experimental Medicine]
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Roles of Circadian Clocks in Cancer Pathogenesis and Treatment

Scientists discuss the roles of circadian rhythms in cancer pathogenesis, highlighting the recent advances in chronotherapeutic approaches for improved cancer treatment.
[Experimental & Molecular Medicine]
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CRISPR Screens Identify Cholesterol Biosynthesis as a Therapeutic Target on Stemness and Drug Resistance of Colon Cancer

To identify genetic vulnerabilities of colon cancer, investigators performed targeted CRISPR dropout screens comprising 657 Drugbank targets and 317 epigenetic regulators on two patient-derived colon cancer stem cells-enriched spheroids.
[Oncogene]
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Single-Cell RNA Sequencing Reveals Cell Heterogeneity and Transcriptome Profile of Breast Cancer Lymph Node Metastasis

Scientists identified nine cancer cell subclusters including CD44+/ALDH2+/ALDH6A1+ breast cancer stem cells, which had a copy-number variants profile similar to that of normal breast tissue.
[Oncogenesis]
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