International Regenerative Medicine Expert Will Lead CSU Translational Medicine Institute

Frank Barry, Ph.D., has been selected as the new director of the C. Wayne McIlwraith Translational Medicine Institute at Colorado State University. Barry’s research and interests include stem cell biology and the development of cell-based repair strategies for osteoarthritis.
[Colorado State University]
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Researchers Receive National Award to Further Study Muscular Dystrophy, Cancer and Heart Failure

Three Virginia Commonwealth University researchers were awarded funding that will support the expansion of their health research and translation of that research into improved care for patients.
[Virginia Commonwealth University]
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m6A Modification of circHPS5 Facilitates Cytoplasmic Export and Promotes Hepatocellular Carcinoma Progression by Enhancing HMGA2 Expression

Silencing of circHPS5 inhibited epithelial-mesenchymal transition and cancer stem-like cell (CSC) phenotypes. METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5.
[Molecular Therapy-Nucleic Acids]
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FOXC1 Modulates Stem-Like Cell Properties and Chemoresistance through Hedgehog and EMT Signaling in Gastric Adenocarcinoma

The function of the only gene overexpressed in both chemoresistant tumors and tumor tissue relative to normal gastric epithelia, FOXC1, was examined in gastric adenocarcinoma cells, mouse xenograft models, and patient-derived organoid systems, focusing on cancer stem-like cell phenotypes, metastasis, and chemoresistance
[Molecular Therapy]
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RASSF1C Oncogene Elicits Amoeboid Invasion, Cancer Stemness, and Extracellular Vesicle Release via a SRC/Rho Axis

Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.
[EMBO Journal]
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miR-151a-3p-Rich Small Extracellular Vesicles Derived from Gastric Cancer Accelerate Liver Metastasis via Initiating a Hepatic Stemness-Enhancing Niche

Researchers reported that gastric cancer (GC)-derived small extracellular vesicles (sEV) were primarily absorbed by Kupffer cells and revealed a previously unidentified regulatory axis initiated by sEV-miR-151a-3p that established a hepatic stemness-permissive niche to support GC-liver metastasis.
[Oncogene]
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Δ133p53β Isoform Pro-Invasive Activity Is Regulated through an Aggregation-Dependent Mechanism in Cancer Cells

The authors reported that Δ133p53β activity was regulated through an aggregation-dependent mechanism. Δ133p53β aggregates were observed in cancer cells and tumor biopsies.
[Nature Communications]
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Down-Regulation of lncRNA MEG3 Promotes Chronic Low Dose Cadmium Exposure-Induced Cell Transformation and Cancer Stem Cell-Like Property

The long non-coding RNA microarray analysis showed that the expression level of a tumor suppressive lncRNA maternally expressed 3 was significantly down-regulated in cadium-transformed cells, which was confirmed by further q-PCR analysis.
[Toxicology and Applied Pharmacology]
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STRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism

The authors generated Strap intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments.
[Gastroenterology]
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Exosomal MicroRNA-19b Targets FBXW7 to Promote Colorectal Cancer Stem Cell Stemness and Induce Resistance to Radiotherapy

The regulatory role of miR-19b in colorectal cancer stem cells and radiotherapy-resistant cells was determined using miRNA microarray analysis, and its prognostic value was probed using the TCGA database.
[Kaohsiung Journal of Medical Sciences]
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Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model

Researchers characterized the time-dependent impact of regadenoson on brain endothelial cell interactions and paracellular transport, using mouse and rat brain endothelial cells and tumor models.
[Molecular Cancer Research]
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