Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

An Ellagic Acid Coordinated Copper-Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness

[Small] Ellagic acid inhibited stemness maintenance by suppressing the hedgehog pathway, while Cu2+ further decreased stemness features of tumor cells by disrupting mitochondrial metabolism, effectively enhancing doxorubicin-mediated chemotherapy.

Distinctive Mesenchymal-Like Neurofibroma Stem Cells Shape NF1 Clinical Phenotypes Controlled by BDNF Microenvironment

[Translational Oncology] Researchers determined the phenotypic and therapeutic relevance of tumor microenvironment in neurofibroma type I (NF1) patients. Tumor stem cell from NF1 were isolated and cultured using fluorescence activated cell sorting and colony formation experiments.

METTL3 Facilitates Stemness Properties and Tumorigenicity of Cancer Stem Cells in Hepatocellular Carcinoma through the SOCS3/JAK2/STAT3 Signaling Pathway

[Cancer Gene Therapy] Loss- and gain-of-function experiments were utilized to assess the biological effects of METTL3 and SOCS3 on the proliferation and stemness phenotypes in vitro and in vivo.

Targeting ABCA12-Controlled Ceramide Homeostasis Inhibits Breast Cancer Stem Cell Function and Chemoresistance

[Science Advances] Investigators developed a stem cell factor SOX9-based reporter for isolating CSCs in primary tumors and metastases of spontaneous mammary tumor models.

MiR-204 Suppresses Cancer Stemness and Enhances Osimertinib Sensitivity in Non-Small Cell Lung Cancer by Targeting CD44

[Molecular Therapy - Nucleic Acids] Scientists explored novel miRNA–mRNA regulatory mechanisms that contribute to osimertinib resistance in lung cancer. They found that miR-204 expression in osimertinib-resistant lung cancer cells was markedly reduced compared to that in osimertinib-sensitive parental cells.

RAB27B-Regulated Exosomes Mediate LSC Maintenance via Resistance to Senescence and Crosstalk with the Microenvironment

[Leukemia] Investigators found that increased RAB27B in leukemia stem cells prevented their senescence and maintained their stemness in vitro and in vivo.

The Promoting Effect and Mechanism of MAD2L2 on Stemness Maintenance and Malignant Progression in Glioma

[Journal of Translational Medicine] Scientists elucidated the role of Mitotic arrest deficient 2 like 2 (MAD2L2) in maintaining glioblastoma stemness and promoting malignant behaviors through the regulation of c-MYC.

Transcription Factor MITF Inhibits the Transcription of CPT1B to Regulate Fatty Acid β-Oxidation and Thus Affects Stemness in Lung Adenocarcinoma Cells

[Pharmacology] Transcription factor MITF inhibited transcription of CPT1B to regulate fatty acid β-oxidation, thereby suppressing stemness in lung adenocarcinoma cells.

Inhibition of Mitochondria Induces Apoptosis and Reduces Telomere Length and Activity in Acute Myeloid Leukemia Stem Cells

[Cell Biochemistry And Function] Investigators evaluated whether leukemia stem cells was influenced by mitochondrial inhibition.They demonstrated that the inhibition of mitochondrial activity by tigecycline affects CSCs in comparison with other cells.

Inhibiting NR5A2 Targets Stemness in Pancreatic Cancer by Disrupting SOX2/MYC Signaling and Restoring Chemosensitivity

[Journal of Experimental & Clinical Cancer Research] The authors elucidated the function of the nuclear receptor subfamily 5, group A, member 2 (NR5A2) in the context of pancreatic CSCs.

RCC2 Promotes Prostate Cancer Cell Proliferation and Migration through Hh/GLI1 Signaling Pathway and Cancer Stem-Like Cells

[Biology Direct] Researchers explored the function of regulator of chromosome condensation 2 (RCC2) on prostate cancer (PCa) development. They found that RCC2 promoted PCa development through Hh/Gli1 signaling pathway via regulating epithelial-mesenchymal transition and CSCs.

1-Benzylimidazole Attenuates the Stemness of Breast Cancer Cells through Partially Targeting CYP4Z1

[Environmental Toxicology] RNA sequencing found that 1-benzylimidazole held a preferable correlation with breast cancer and suppressed the expression of CSC makers.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.