Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Self-Assembled Aldehyde Dehydrogenase-Activatable Nano-Prodrug for Cancer Stem Cell-Enriched Tumor Detection and Treatment

[Nature Communications] Scientists reported a self-assembled nano-prodrug composed of aldehyde dehydrogenases activatable photosensitizer and disulfide-linked all-trans retinoic acid for diagnosis and targeted treatment of CSCs enriched tumors.

Polyclonality Overcomes Fitness Barriers in Apc-Driven Tumorigenesis

Investigators combined multicolor lineage tracing with chemical mutagenesis in mice to show that a large proportion of intestinal tumours have a multiancestral origin. Polyclonal...

EVA1-Antibody Drug Conjugate Is a New Therapeutic Strategy for Eliminating Glioblastoma-Initiating Cells

[Neuro-Oncology] Hybridoma cells were generated by immunizing BALB/c mice with EVA1-Fc fusion protein. The reactivity of the supernatant from these hybridoma cells was examined using EVA1-overexpressing cells and glioblastoma-initiating cells. Candidate antibodies were further selected using Biacore surface plasmon resonance analysis and two cytotoxicity assays, antibody-dependent cell cytotoxicity and complement-dependent cytotoxicity

RAS-Mutant Leukemia Stem Cells Drive Clinical Resistance to Venetoclax

[Nature] Investigators provide the mechanistic explanation for this in a requirement for mutant RAS to specifically transform committed progenitors of the myelomonocytic lineage harboring previously acquired driver mutations, showing that advanced leukemic clones can originate from a different cell type in the hematopoietic hierarchy than ancestral clones.

Non-Glycanated ΔDCN Isoform in Muscle Invasive Bladder Cancer Mediates Cancer Stemness and Gemcitabine Resistance

[Cellular Oncology] The authors obtained data were acquired from TCGA and GEO. The bladder cancer stem cells were cultured by enriching the suspension culture in a serum-free medium, followed by flow cytometry sorting.

Combined Targeting of GPX4 and BCR-ABL Tyrosine Kinase Selectively Compromises BCR-ABL+ Leukemia Stem Cells

[Molecular Cancer] Investigators demonstrated that Disulfiram induced ferroptosis to synergize with TKIs in inhibiting BCR-ABL+ cells, particularly targeting resistant cells and leukemia stem cells, using cell models, mouse models, and primary cells from patients.

Two OHSU Researchers Receive Prestigious Cancer Moonshot Scholars Award to Advance Cancer Research, Innovation

[OSHU] The National Cancer Institute announced the second cohort of Cancer Moonshot Scholars, a program launched by the Biden-Harris Administration to “support early-career researchers and help build a cancer research workforce that better represents the diversity of America.”

Sugar Symphony: Glycosylation in Cancer Metabolism and Stemness

[Trends In Cell Biology] Scientists explore how differential glycosylation in cancer influences the metabolism and stemness features alongside new avenues in glycobiology.

Stemness in Solid Malignancies: Coping with Immune Attack

[Nature Reviews Cancer] Scientists focus on advancements in understanding how CSCs in solid tumours achieve their unique immune-evasive properties, enabling them to drive tumor regrowth.

ROR1 Facilitates Glioblastoma Growth via Stabilizing GRB2 to Promote C-Fos Expression in Glioma Stem Cells

[Neuro-Oncology] The expression characteristics of ROR1 in glioblastoma and glioma stem cells (GSCs) were assessed by bioinformatic analysis, patient specimens, and patient-derived GSCs. Lentivirus-mediated gene knockdown and overexpression were conducted to evaluate the effect of ROR1 on GSCs proliferation and self-renewal both in vitro and in vivo.

Delphinidin or α-Amyrin Attenuated Liver Steatosis and Metabolic Disarrangement in Rats Fed a High-Fat Diet

[Biofactors] Investigators assessed the therapeutic impacts of delphinidin, an anthocyanin, or α-amyrin, a pentacyclic triterpenoid, on non-alcoholic fatty liver disease in rats and the underlying mechanisms involved.

Delphinidin or α-Amyrin Attenuated Liver Steatosis and Metabolic Disarrangement in Rats Fed a High-Fat Diet

[Biofactors] Investigators assessed the therapeutic impacts of delphinidin, an anthocyanin, or α-amyrin, a pentacyclic triterpenoid, on non-alcoholic fatty liver disease in rats and the underlying mechanisms involved.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.

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