Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Targeting Cancer Stem Cells in Multiple Myeloma

[Trends In Cancer] Investigators review advances in understanding MMSCs and their role in drug resistance to multiple myeloma (MM) therapies. They also discuss novel therapeutic strategies to overcome MM stem cell-mediated relapses and drug resistance.

FXN Targeting Induces Cell Death in Ovarian Cancer Stem-Like Cells through PRDX3-Mediated Oxidative Stress

[iScience] Investigators enriched ovarian cancer stem-like cells (OCSCs) through mammosphere culture, as an OCSC model. OCSLCs displayed heightened ferroptosis susceptibility, correlating with elevated FXN levels compared to non-stem ovarian cancer cells.

PHF6 Suppresses Self-Renewal of Leukemic Stem Cells in AML

[Leukemia] Scientists reported that Phf6 knockout increased the aggressiveness of Hoxa9-driven acute myeloid leukemia over serial transplantation, and increases the frequency of leukemia initiating cells.

Changes of Circulating Tumor Cells Expressing CD90 and EpCAM in Early-Phase of Atezolizumab and Bevacizumab for Hepatocellular Carcinoma

[Heliyon] Researchers investigated the cellular characteristics of circulating tumor cells focusing on monitoring during atezolizumab and bevacizumab therapy in patients with HCC. Peripheral blood samples were collected from 10 healthy controls and 40 patients with HCC.

Disruption of TGF-β Signaling Pathway Is Required to Mediate Effective Killing of Hepatocellular Carcinoma by Human iPSC-Derived NK Cells

[Cell Stem Cell] The authors used human induced pluripotent stem cells (iPSCs) to produce natural killer (NK) cells engineered to mediate improved anti-HCC activity.

Post-Translational Modifications: The Potential Ways for Killing Cancer Stem Cells

[Heliyon] Investigators accentuate the critical significance of several prevalent post-translational protein modifications post-translational protein modifications (PTMs) and the intricate interplay of PTM crosstalk in regulating CSC behavior.

Suppress the Cell Growth of Cancer Stem-Like Cells (NTERA-2) Using Sox2-Oct4 Decoy Oligodeoxynucleotide−Encapsulated Niosomes-Zinc Hybrid Nanocarriers under X-Irradiation

[Heliyon] The synergistic effects of Sox2-Oct4 decoy oligodeoxynucleotides-encapsulated Niosomes-zinc hybrid nanocarriers along with X‐irradiation conditions as a combinational therapy tool were investigated in the treatment of cancer-like stem cells.

FERMT1 Suppression Induces Anti-Tumor Effects and Reduces Stemness in Glioma Cancer Cells

[Journal of Cancer Research and Clinical Oncology] The authors investigated the potential of FERMT1 as a prognostic biomarker and its role in regulating stemness through cell cycle in glioma.

Inhibiting Bruton’s Tyrosine Kinase to Counteract Chemoresistance and Stem Cell-Like Properties in Osteosarcoma

[Environmental Toxicology] Researchers delved into the expression levels of Bruton's tyrosine kinase in osteosarcoma tissues by data from the GEO and TCGA database, revealing a marked increase in BTK expression compared with primary osteoblasts and a potential correlation with primary site progression.

CENPA Facilitates Glioma Stem Cell Stemness and Suppress Ferroptosis to Accelerate Glioblastoma Multiforme Progression by Promoting GBP2 Transcription

[Pathology - Research and Practice] GSCs proliferation and stemness were assessed using EdU assay and sphere formation assay. Cell ferroptosis was evaluated by detecting related factors.

Promotion of Stem Cell-Like Phenotype of Lung Adenocarcinoma by FAM83A via Stabilization of ErbB2

[Cell Death & Disease] Through a global proteomics analysis, the study identifies human epidermal growth factor receptor 2 as a crucial target of FAM83A. Mechanistically, FAM83A facilitated ErbB2 expression at the posttranslational modification level via the E3 ubiquitin ligase STUB1.

Two Faculty of Health Sciences Cancer Researchers Awarded Canada Research Chairs

[McMaster University] Two members of McMaster’s Faculty of Health Sciences and the Centre for Discovery in Cancer Research have been named Canada Research Chairs. Dr. Hong Han is focused on high-throughput investigation of cancer biology, specifically alternative splicing and coordinated multilayer gene regulations that impact cancer progression, therapy response and relapse.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.