Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

FAP, CD10, and GPR77-Labeled CAFs Cause Neoadjuvant Chemotherapy Resistance by Inducing EMT and CSC in Gastric Cancer

[BMC Cancer] One hundred seventy-one patients with locally progressive gastric adenocarcinoma who had undergone neoadjuvant chemotherapy and radical surgery were collected. Immunohistochemistry was used to detect the expression of FAP, CD10, and GPR77 in cancer-associated fibroblasts.

Combined Lineage Tracing and scRNA-Seq Reveals Unexpected First Heart Field Predominance of Human iPSC Differentiation

[eLife] The authors described the development of a TBX5/MYL2 lineage tracing reporter system that allows for the identification of FHF- progenitors and their descendants including left ventricular cardiomyocytes.

GSK-3α/β and MEK Inhibitors Assist the Microenvironment of Tumor Initiation

[Cytotechnology] Human iPSCs reprogrammed from monocytes of healthy volunteers were cultured in a media containing 50% of the conditioned medium from human pancreatic cancer derived BxPC3 cells supplemented with a MEK inhibitor and a GSK-3α/β inhibitor.

Non-Lethal Outcomes of Engaging Regulated Cell Death Pathways in Cancer

[Nature Cancer] Regulated cell death (RCD) is essential for successful systemic cancer therapy. Cells which survive RCD pathways harbor important functions, which can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.

Aldehyde Dehydrogenase, a Marker of Normal and Malignant Stem Cells, Typifies Mesenchymal Progenitors in Perivascular Niches

[Stem Cells Translational Medicine] The authors evaluated the activity of aldehyde dehydrogenase, a family of enzymes catalyzing the oxidation of aldehydes into carboxylic acids and a reported biomarker of normal and malignant stem cells, within human adipose tissue perivascular areas.

MT1M Regulates Gastric Cancer Progression and Stemness by Modulating the Hedgehog Pathway Protein GLI1

[Biochemical And Biophysical Research Communications] Scientists investigated the expression and function of metallothionein 1 M (MT1M) in gastric cancer both in vitro and in vivo, and found that MT1M expression was significantly downregulated in GC tissues and cell lines.

SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence

[Stem Cells International] SET domain-containing protein 4 (SETD4)-positive cells were identified as quiescent lung cancer stem cells, since they expressed high levels of ALDH1 and CD133 and low levels of Ki67.

Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold

[Cancer Research] Investigators identified cold sensitivity at 4°C, commonly used for sample storage, as a novel vulnerability that selectively killed acute myeloid leukemic stem cells with active fatty acid oxidation-supported mitochondrial oxidative phosphorylation while sparing normal hematopoietic stem cells.

Acute Myeloid Leukemia (AML)-Derived Mesenchymal Stem Cells Induce Chemoresistance and Epithelial-Mesenchymal Transition-Like Program in AML Through IL-6/JAK2/STAT3 Signaling

[Cancer Science] Researchers found that AML-mesenchymal stem cellss induced a significant mesenchymal-like morphology in drug-resistant AML cells, but it was scarce in parental AML cells.

Structural Modification of Resveratrol Analogue Exhibits Anticancer Activity against Lung Cancer Stem Cells via Suppression of Akt Signaling Pathway

[BMC Complementary Medicine And Therapies] CSC-rich populations of A549 cells were generated, and CSC markers, and Akt signaling were determined by Western blot analysis and immunofluorescence.

High Expression of PKCλ and ALDH1A3 Indicates a Poor Prognosis, and PKCλ Is Required for the Asymmetric Cell Division of ALDH1A3-Positive Cancer Stem Cells...

[Biochemical And Biophysical Research Communications] To monitor asymmetric cell division of ALDH1A3-positive pancreatic ductal adenocarcinoma (PDAC) CSCs, researchers established stable Panc-1 PDAC clones expressing ALDH1A3-turboGFP.

Therapeutic Inhibition of BMI-1 Ablates Chemoresistant Cancer Stem Cells in Adenoid Cystic Carcinoma

[Oral Oncology] Therapeutic efficacy of a small molecule inhibitor of Bmi-1 and/or Cisplatin on adenoid cystic carcinoma (ACC) stemness was evaluated in immunodeficient mice harboring PDX ACC tumors, and in human ACC cell-lines, or low passage primary human ACC cells.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.