Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

FDA Floats Oncology Authorization Shake-Up, Pitching ‘One-Trial’ Model for Accelerated and Full Approval

[Fierce Biotech] In draft guidance, the FDA outlined plans to move away from single-arm studies and instead favor randomized controlled trials that can potentially serve as the basis for both accelerated and full approval.

Profiling of Circulating Tumor Cells for Screening of Selective Inhibitors of Tumor-Initiating Stem-Like Cells

[Advanced Science] Investigators identified circulating tumor cell-biomarkers and effective combinations of tumor-initiating stem-like cell-specific, repurposed FDA-approved drugs.

Matrix Gla Protein Drives Stemness and Tumor Initiation in Ovarian Cancer

[Cell Death & Disease] Researchers investigated the molecular and funcitonal makeup of ovarian CSCs (OCSCs) in clinically relevant model systems, and revealed that Matrox Gla Protein, was markedly enriched in OCSCs.

Development of DNA Aptamers for Visualization of Glial Brain Tumors and Detection of Circulating Tumor Cells

[Molecular Therapy - Nucleic Acids] Scientists presented DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors.

Tumor Microenvironment-Responsive Nanoherb Delivery System for Synergistically Inhibition of Cancer Stem Cells

[ACS Applied Materials & Interfaces] Monodisperse hollow-structured MnO2 was successively modified with hyaluronic acid to enhance targeting CSCs with high CD44 expression levels.

TIPE2 Sensitizes Breast Cancer Cells to Paclitaxel by Suppressing Drug-Induced Autophagy and Cancer Stem Cell Properties

[Human Cell] The in vitro and in vivo study demonstrated that tumor necrosis factor-α-induced protein-8-like-2 (TIPE2) sensitized breast cancer cells to paclitaxel by suppressing drug-induced autophagy and CSC properties.

Terminally Exhausted CD8+ T Cells Resistant to PD-1 Blockade Promote Generation and Maintenance of Aggressive Cancer Stem Cells

[Cancer Research] Researchers reported that TTEX cells actively participated in tumor progression by modulating CSCs. TTEX cells strongly correlated with elevated CSC frequency in poorly immune-infiltrated advanced human breast and ovarian carcinomas.

G9a Promotes Immune Suppression by Targeting the Fbxw7/Notch Pathway in Glioma Stem Cells

[CNS Neuroscience & Therapeutics] The authors investigated the effects of histone methyltransferases 2, EHMT2 or G9a, on immunosuppressive tumor microenvironment and whether this effect was related to changes on cell stemness.

Discovery of YH677 as a Cancer Stemness Inhibitor That Suppresses Triple-Negative Breast Cancer Growth and Metastasis by Regulating the TGFβ Signaling Pathway

[Cancer Letters] Harmine was identified as a hit compound based on phenotypic screening of a 2D assay and patient-derived organoid model that was established from a patient with multiple drug resistance and breast metastases.

A Novel Lonidamine Derivative Targeting Mitochondria to Eliminate Cancer Stem Cells by Blocking Glutamine Metabolism

[Pharmacological Research] Investigators reported a novel derivative of lonidamine, namely HYL001, which selectively and potently inhibited CSCs by targeting mitochondria.

Eradicating the Tumor “Seeds”: Nanomedicines-Based Therapies against Cancer Stem Cells

[Daru-Journal Of Pharmaceutical Sciences] The authors summarize the biological hallmarks and markers of CSCs, and the nanotechnology-based therapies to eradicate them.

Cancer-Associated Fibroblast-Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance

[Cancer Research] To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, scientists focused on the role of cancer-associated fibroblasts.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.