NR2F2 Controls Malignant Squamous Cell Carcinoma State by Promoting Stemness and Invasion and Repressing Differentiation

Using transcriptional profiling of cancer stem cells from benign tumors and malignant skin squamous cell carcinoma (SCC), scientists identified the nuclear receptor NR2F2 as uniquely expressed in malignant SCC.
[Nature Cancer]
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Metabolic Stress Induces GD2+ Cancer Stem Cell-Like Phenotype in Triple-Negative Breast Cancer

Researchers tested the hypothesis that metabolic stress induced breast cancer stem-like cell phenotype in triple-negative breast cancer.
[British Journal of Cancer]
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TMPRSS4 Promotes Cancer Stem–Like Properties in Prostate Cancer Cells through Upregulation of SOX2 by SLUG and TWIST1

The authors investigated whether transmembrane serine protease 4 (TMPRSS4) confered cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.
[Journal of Experimental & Clinical Cancer Research]
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ABHD5 Inhibits YAP-Induced C-Met Overexpression and Colon Cancer Cell Stemness via Suppressing YAP Methylation

Researchers showed that loss of ABHD5 promoted c-Met activation to sustain colorectal cancer stemness in a non-canonical manner.
[Nature Communications]
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First Subject Dosed in Biosplice Therapeutics Phase Ib Clinical Trial in Oncology

Biosplice Therapeutics, Inc. announced the dosing of the first subject in a Phase Ib, open-label, multicenter, dose-escalation, dose expansion clinical trial of cirtuvivint in subjects with advanced solid tumors.
[Biosplice Therapeutics, Inc.]
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GLRX3, a Novel Cancer Stem Cell-Related Secretory Biomarker of Pancreatic Ductal Adenocarcinoma

Secretome analysis was performed in pancreatic CSC-enriched spheres and controlled adherent cells for biomarker discovery.
[BMC Cancer]
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Heterogeneity of BCSCs Contributes to the Metastatic Organotropism of Breast Cancer

Scientists summarize current clinical trials, which assessed the safety and efficacy of breast cancer stem cells-related therapies.
[Journal of Experimental & Clinical Cancer Research]
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The Sulfiredoxin-Peroxiredoxin Redox System Regulates the Stemness and Survival of Colon Cancer Stem Cells

Scientists assessed the role of the sulfiredoxin-peroxiredoxin redox system and mitochondrial oxidative phosphorylation in maintaining the stemness and survival of colon CSCs.
[Redox Biology]
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ZRANB1 Enhances Stem-Cell-Like Features and Accelerates Tumor Progression by Regulating Sox9-Mediated USP22/Wnt/β-Catenin Pathway in Colorectal Cancer

Scientists examined the regulatory effects of ZRANB1 on the maintenance of CSC properties and tumor growth in colorectal cancer.
[Cellular Signalling]
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Autophagy Regulates the Cancer Stem Cell Phenotype of Head and Neck Squamous Cell Carcinoma through the Noncanonical FOXO3/SOX2 Axis

The mechanism by which autophagy affects the self-renewal of CSCs remains unclear. Researchers investigated whether autophagy activation contributes to CSC properties of head and neck squamous cell carcinoma.
[Oncogene]
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The IVF-Generated Human Embryonic Microenvironment Reverses Progestin Resistance in Endometrial Cancer Cells by Inducing Cancer Stem Cell Differentiation

Scientists found that progestin resistance of endometrial CSCs could be improved or reversed by using in vitro fertilization (IVF)-generated embryonic sac-derived fluid containing the embryonic microenvironment.
[Cancer Letters]
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