Adipocyte-Like Signature in Ovarian Cancer Minimal Residual Disease Identifies Metabolic Vulnerabilities of Tumor Initiating Cells

Investigators performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy.
[JCI Insight]
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An RFC4/Notch1 Signaling Feedback Loop Promotes NSCLC Metastasis and Stemness

To understand how Notch signaling was overactivated to couple tumor metastasis and self-renewal in NSCLC cells, researchers showed that RFC4, directly bound to the Notch1 intracellular domain (NICD1) to competitively abrogate CDK8/FBXW7-mediated degradation of NICD1.
[Nature Communications]
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Mucosal Ribosomal Stress-Induced PRDM1 Promotes Chemoresistance via Stemness Regulation

Stress-driven ribosomal dysfunction enhanced PR domain zinc finger protein 1 (PRDM1) levels in intestinal cancer cells, which contributed to their survival and enhanced cancer cell stemness against cancer treatment.
[Communications Biology]
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Functional Inhibition of Cancer Stemness-Related Protein DPP4 Rescues Tyrosine Kinase Inhibitor Resistance in Renal Cell Carcinoma

The authors established patient-derived renal cell carcinoma spheroids and showed that dipeptidyl peptidase IV (DPP4) expression was associated with stemness-related gene expression.
[Oncogene]
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WPD Pharmaceuticals to Receive $6.7 Million Grant for Development of Annamycin Drug Candidate

WPD Pharmaceuticals, Inc. announced that it has been conditionally awarded a grant of $6,730,036 from the Polish National Center for Research and Development, for the development of Annamycin, the company’s drug candidate used in the treatment of Acute Myeloid Leukemia.
[WPD Pharmaceuticals, Inc.]
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C/EBPβ Is a MYB- and p300-Cooperating Pro-leukemogenic Factor and Promising Drug Target in Acute Myeloid Leukemia

Scientists characterized a group of natural sesquiterpene lactones, previously shown to suppress MYB activity, for their potential to decrease AML cell proliferation.
[Oncogene]
Yusenko, M. V., Trentmann, A., Casolari, D. A., Abdel Ghani, L., Lenz, M., Horn, M., Dörner, W., Klempnauer, S., Mootz, H. D., Arteaga, M. F., Mikesch, J.-H., Andrea, R. J. D., Gonda, T. J., Müller-Tidow, C., Schmidt, T. J., & Klempnauer, K.-H. (2021). C/EBPβ is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01800-x Cite
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LncRNA SLCO4A1-AS1 Modulates Colon Cancer Stem Cell Properties by Binding to miR-150-3p and Positively Regulating SLCO4A1

The authors explored the specific role of solute carrier organic anion transporter family member 4A1-AS1 (SLCO4A1-AS1) in colon CSCs.
[Laboratory Investigation]
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YTHDF2 Is a Potential Target of AML1/ETO-HIF1α Loop-Mediated Cell Proliferation in t(8; 21) AML

Scientists showed that YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) was highly expressed in t(8;21) acute myeloid leukemia (AML) patients and associated with a higher risk of relapse and inferior relapse-free survival. Knockdown of YTHDF2 in leukemia cells caused an impaired cell proliferation rate in vitro and in mice.
[Oncogene]
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Hematopoietic Stem Cells Retain Functional Potential and Molecular Identity in Hibernation Cultures

The authors describe a powerful seven day HSC hibernation culture system that maintained HSCs as single cells in the absence of a physical niche.
[Stem Cell Reports]
Oedekoven, C. A., Belmonte, M., Bode, D., Hamey, F. K., Shepherd, M. S., Che, J. L. C., Boyd, G., McDonald, C., Belluschi, S., Diamanti, E., Bastos, H. P., Bridge, K. S., Göttgens, B., Laurenti, E., & Kent, D. G. (2021). Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.04.002 Cite
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Detection of Metabolic Change in Glioblastoma Cells after Radiotherapy Using Hyperpolarized 13C-MRI

Dynamic nuclear polarization‐magnetic resonance imaging chemical shift imaging with hyperpolarized [1‐13C] pyruvate was conducted to evaluate the metabolic change in glycolytic profiles after radiation of two glioma stem‐like cell‐derived gliomas and an adherent human glioblastoma cell line in an orthotopic xenograft mouse model.
[Nmr in Biomedicine]
Kawai, T., Brender, J. R., Lee, J. A., Kramp, T., Kishimoto, S., Krishna, M. C., Tofilon, P., & Camphausen, K. A. (n.d.). Detection of metabolic change in glioblastoma cells after radiotherapy using hyperpolarized 13C-MRI. NMR in Biomedicine, n/a(n/a), e4514. https://doi.org/https://doi.org/10.1002/nbm.4514 Cite
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ALG3 Contributes to Stemness and Radioresistance through Regulating Glycosylation of TGF-β Receptor II in Breast Cancer

Scientists screened all ten asparagine-linked glycosylation (ALG) members in breast cancer patients’ samples by RT-PCR. Cancer stem-like traits were assessed by RT-PCR, Western blot, and flow cytometry.
[Journal of Experimental & Clinical Cancer Research]
Sun, X., He, Z., Guo, L., Wang, C., Lin, C., Ye, L., Wang, X., Li, Y., Yang, M., Liu, S., Hua, X., Wen, W., Lin, C., Long, Z., Zhang, W., Li, H., Jian, Y., Zhu, Z., Wu, X., & Lin, H. (2021). ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 149. https://doi.org/10.1186/s13046-021-01932-8 Cite
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