Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Colorado Blood Cancer Institute Using Patients’ Stem Cells to Treat Their Autoimmune Diseases
[Denver7] The Colorado Blood Cancer Institute at Presbyterian/St. Luke’s is leading the way in a type of stem cell therapy to treat autoimmune diseases, including multiple sclerosis.
Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti-Tumor Immunity
[Advanced Science] Two new potent small-molecule inhibitors of Arf1, identified as DU101 and DU102, for cancer therapy are introduced. Preclinical tumor models demonstrated that these inhibitors triggered a cascade of aging in CSCs and enhanced anti-tumor immunity in mouse cancer and PDX models.
The Dual Role of POSTN in Maintaining Glioblastoma Stem Cells and the Immunosuppressive Phenotype of Microglia in Glioblastoma
[Journal of Experimental & Clinical Cancer Research] Scientists investigated the role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia.
Acid-Sensing Ion Channel 3 Is a New Potential Therapeutic Target for the Control of Glioblastoma Cancer Stem Cells Growth
[Scientific Reports] Researchers reported that the acid-sensing ion channel 3 isoform, usually absent in the central nervous system and present in the peripheral nervous system, was enriched in human glioblastoma cancer stem cells while poorly expressed in the healthy human brain.
Genetically Engineered CD276-Anchoring Biomimetic Nanovesicles Target Senescent Escaped Tumor Cells to Overcome Chemoresistant and Immunosuppressive Breast Cancer
[Biomaterials] Investigators developed new approaches for selectively killing senescent-escape CSCs. High CD276 expression in multidrug-resistant breast cancer cells, facilitated immune evasion by low-immunogenic senescent escape CSCs.
Epigenetic Therapy Potentiates Transposable Element Transcription to Create Tumor-Enriched Antigens in Glioblastoma Cells
[Nature Genetics] Researchers treated patient-derived primary glioblastoma stem cell lines, an astrocyte cell line, and primary fibroblast cell lines with epigenetic drugs, and identified treatment-induced, transposable element-derived transcripts preferentially expressed in cancer cells.
TRIM24/ZFX Affects the Stemness and Resistance to 5-FU of Colorectal Cancer Cells
[Journal of Chemotherapy] Scientists explored the effects of tripartite motif containing 24 (TRIM24) and zinc finger protein, X-linked (ZFX) on colorectal cancer cell stemness and 5-FU resistance.
FOSL1 Promotes Stem Cell-Like Characteristics and Anoikis Resistance to Facilitate Tumorigenesis and Metastasis in Osteosarcoma by Targeting SOX2
[International Journal of Molecular Medicine] The dynamic expression patterns of Fos‑like antigen 1 (FOSL1) were investigated during the acquisition of cancer stem‑like properties using RNA sequencing, PCR, western blotting, and immunofluorescence.
Identification of SPP1+ Macrophages in Promoting Cancer Stemness via Vitronectin and CCL15 Signals Crosstalk in Liver Cancer
[Cancer Letters] Investigators analyzed single-cell RNA sequencing data from 12 patients with liver cancer and identified a subpopulation of macrophages characterized by elevated expression of SPP1. These SPP1+ macrophages induced upregulation of tumor stemness through a vitronectin-dependent paracrine mechanism.
Understanding the Intersection Between Placental Development and Cancer: Lessons From the Tumor Suppressor BAP1
[Communications Biology] Investigators explore the multifaceted role of the tumor suppressor BRCA1-associated protein 1 (BAP1) in cancer and placentation. Initially recognized for its tumor-suppressive properties, BAP1 has emerged as a key regulator at the intersection of tumorigenesis and placental development.
Chromosome 9p Trisomy Increases Stem Cells Clonogenic Potential and Fosters T Cell Exhaustion in JAK2-Mutant Myeloproliferative Neoplasms
[Leukemia] Researchers identified a subset of MPN patients with partial or complete Chromosome 9 trisomy, who differed from JAK2V617F-homozygous MPN patients as they carry three JAK2 alleles as well as three copies of all neighboring gene loci, including CD274, encoding immunosuppressive Programmed death-ligand 1 protein.
Identification of Leukemia Stem Cell Subsets With Distinct Transcriptional, Epigenetic and Functional Properties
[Leukemia] Researchers used the patient-derived OCI-AML22 cell model, which included functionally, transcriptionally and epigenetically characterized leukemia stem cells (LSCs( broadly representative of the LSCs found in primary AML samples.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
