Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

TSP50 Facilitates Breast Cancer Stem Cell-Like Properties Maintenance and Epithelial-Mesenchymal Transition via PI3K p110α Mediated Activation of AKT Signaling Pathway

[Journal of Experimental & Clinical Cancer Research] TSP50 was negatively correlated with the prognosis of patients with breast cancer. TSP50 promoted CSC-like traits and EMT in both breast cancer cells and mouse xenograft tumor tissues.

Discovering Cancer Stem-Like Molecule, Nuclear Factor I X, Using Spatial Transcriptome in Gastric Cancer

[Cancer Science] Researchers identified Nuclear Factor IX (NFIX) as a critical regulator of cancer stemness in gastric cancer and evaluated its clinicopathological significance and function.

Polyploid Giant Cancer Cells Induced by Docetaxel Exhibit a Senescence Phenotype With the Expression of Stem Cell Markers in Ovarian Cancer Cells

[PLOS One] Ovarian cancer cells were treated with Docetaxel (Doc), and then the effect of Doc on cellular viability was evaluated by MTT assay and microscopic imaging analysis.

Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

[Molecular Cancer Therapeutics] Investigators generated HOTAIR knock-out high-grade serous ovarian cancer cell lines using paired CRISPR guide RNA design to investigate the function of HOTAIR.

Polyhedral Magnetic Nanoparticles Induce Apoptosis in Gastric Cancer Stem Cells and Suppressing Tumor Growth through Magnetic Force Generation

[Journal of Controlled Release] Scientists introduced a novel therapeutic strategy utilizing polyhedral magnetic nanoparticles functionalized with CD44 antibodies and cell-penetrating peptides to improve uptake by gastric CSCs.

So You Got a Null Result. Will Anyone Publish It?

[Nature News] Researchers have tried a bunch of strategies to get more negative results into the literature. Nature asks whether they are working.

U of A Oncology Researcher Named to the Order of Canada

[University of Alberta] Vickie Baracos, University of Alberta oncology professor, researcher and Alberta Cancer Foundation Chair in Palliative Medicine from 2003-23, was recently awarded the Order of Canada. She was honoured for her groundbreaking insights into the fundamental biology of cachexia.

HER2-Targeted Therapies Beyond Breast Cancer — an Update

[Nature Reviews Clinical Oncology] Scientists provide an update on the current development landscape of HER2-targeted therapies beyond breast cancer, as well as anticipated future HER2-directed treatment strategies to overcome resistance and thereby improve efficacy and patient outcomes.

PIM1 Is a Potential Therapeutic Target for the Leukemogenic Effects Mediated by JAK/STAT Pathway Mutations in T-ALL/LBL

[NPJ Precision Oncology] The authors combined the analysis of molecular data from T-ALL/LBL patients with the generation of hematopoietic cellular models to reveal that JAK/STAT pathway mutations are associated with an aberrant transcriptional profile.

Targeting Cancer Stem Cells in Multiple Myeloma

[Trends In Cancer] Investigators review advances in understanding MMSCs and their role in drug resistance to multiple myeloma (MM) therapies. They also discuss novel therapeutic strategies to overcome MM stem cell-mediated relapses and drug resistance.

FXN Targeting Induces Cell Death in Ovarian Cancer Stem-Like Cells through PRDX3-Mediated Oxidative Stress

[iScience] Investigators enriched ovarian cancer stem-like cells (OCSCs) through mammosphere culture, as an OCSC model. OCSLCs displayed heightened ferroptosis susceptibility, correlating with elevated FXN levels compared to non-stem ovarian cancer cells.

PHF6 Suppresses Self-Renewal of Leukemic Stem Cells in AML

[Leukemia] Scientists reported that Phf6 knockout increased the aggressiveness of Hoxa9-driven acute myeloid leukemia over serial transplantation, and increases the frequency of leukemia initiating cells.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.