Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Engineered Mesenchymal Stem Cell Exosomes Loaded with miR-34c-5p Selectively Promote Eradication of Acute Myeloid Leukemia Stem Cells

[Cancer Letters] The authors employed simultaneous two-step modifications to engineer MSCs and MSC-derived exosomes to create exosomes overexpressing the fused protein lysosome-associated membrane protein 2-interleukin 3 and hematopoietic cell E-selectin/L-selectin ligand.

ALDH1A3 Promotes Invasion and Metastasis in Triple-Negative Breast Cancer by Regulating the Plasminogen Activation Pathway

[Molecular Oncology] To elucidate the mechanism of ALDH1A3-mediated breast cancer metastasis, scientists assessed the effect of aldehyde dehydrogenase 1A3 (ALDH1A3) on the expression of proteases and the regulators of proteases that degrade the extracellular matrix.

Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells

[Cancer Research] Researchers identified that poly(A)-specific ribonuclease (PARN), a key modulator of RNA metabolism, activated EGFR-STAT3 signaling to support glioblastoma stem cells.

A Novel SLC25A1 Inhibitor, Parthenolide, Suppresses the Growth and Stemness of Liver Cancer Stem Cells with Metabolic Vulnerability

[Cell Death Discovery] Scientists showed that administration of parthenolide stimulated cell cycle arrest at the G1 phase, induced apoptosis, and decreased the stemness of liver cancer stem cells.

Notum Enhances Gastric Cancer Stem-Like Cell Properties through Upregulation of Sox2 by PI3K/AKT Signaling Pathway

[Cellular Oncology] Bioinformatics analysis, RT-qPCR, western blot and imunohistochemistry staining were applied to characterize Notum expression in gastric cancer specimens. The early diagnostic value of Notum was analyzed by logistic regression analysis method.

The Role of LOXL2 Induced by Glucose Metabolism-Activated NF-κB in Maintaining Drug Resistance through EMT and Cancer Stemness in Gemcitabine-Resistant PDAC

[Journal Of Molecular Medicine] Researchers investigated the mechanism of lysyl oxide-like 2 (LOXL2) induction and the effect of LOXL2 on epithelial to mesenchymal transition (EMT) and CSC in gemcitabine-resistant pancreatic cancer.

Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

[Neuromolecular Medicine] Investigators showed that rosmarinic acid was cytotoxic against human Daoy and D283 medulloblastoma cells.

USP10 Promotes Intrahepatic Cholangiocarcinoma Cell Survival and Stemness via SNAI1 Deubiquitination

[Journal of Molecular Histology] Scientists revealed that ubiquitin specific peptidase 10 (USP10) attenuated intrahepatic cholangiocarcinoma cell malignancy by deubiquitinating snail family transcriptional repressor 1 (SNAI1).

YAP1 Affects the Prognosis through the Regulation of Stemness in Endometrial Cancer

[Peerj Life & Environment] Researchers collected specimens and clinical data from 774 patients with endometrial cancer to analyze the correlation between YAP1 expression and prognosis.

Stemness Markers in Hepatocellular Carcinoma of Eastern vs. Western Population: Etiology Matters?

[Annals of Hepatology] The authors summarize available data regarding whether various hepatocellular carcinoma etiologies associate to the appearance of CSC biomarkers.

New Scientific Partnership between UK and France to Tackle Greatest Challenges in Cancer

[Cancer Research UK] Cancer Research UK and France’s Institut National Du Cancer announced a new scientific partnership to help fund world-class researchers to take on cancer’s toughest challenges through the global Cancer Grand Challenges initiative.

ARPA-H Launches ARPANET-H: A Nationwide Health Innovation Network

[ARPA-H] ARPANET-H is a nationwide health innovation network that connects people, innovators, and institutions. This network is anchored by three regional hubs.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.