Different concentrations of doxorubicin (DOX), graphene oxide, and graphene oxide plus doxorubicin (GO-DOX) were subjected to MCF7 and BT474 human breast cancer cells at specified intervals.
[Applied Biochemistry and Biotechnology]
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Scientists found STAT5B to be specifically activated in HSCs and leukemic stem cells, where it induced many genes associated with quiescence and self-renewal, including the surface marker CD9.
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To identify drivers of sarcoma cancer stem-like cells, the authors compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.
[Cell Death & Disease]
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Yoon, C., Lu, J., Ryeom, S. W., Simon, M. C., & Yoon, S. S. (2021). PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance. Cell Death & Disease, 12(8), 1–11. https://doi.org/10.1038/s41419-021-04036-5 Cite
The authors silenced two autophagy related genes -either Beclin1 or ATG5- by shRNA and they explored the ensuing consequences on CSCs markers’ expression and functionalities.
The authors investigated the role of acetylsalicylic acid in chemotherapy/chemoprevention in human oesophageal squamous cell carcinoma (ESCC) cell lines and an N-nitrosomethylbenzylamine-induced rat ESCC carcinogenesis model.
[British Journal of Cancer]
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Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.
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Investigators identified a previously unrecognized role of the pro-autophagy factor AMBRA1 in regulating medulloblastoma .
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Nazio, F., Po, A., Abballe, L., Ballabio, C., Diomedi Camassei, F., Bordi, M., Camera, A., Caruso, S., Caruana, I., Ferraina, C., Milletti, G., Gianesello, M., Reddel, S., De Luca, C. D., Ceglie, D., Marinelli, S., Campello, S., Papaleo, E., Miele, E., … Cecconi, F. (2021). Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling. Acta Neuropathologica. https://doi.org/10.1007/s00401-021-02347-7 Cite
Researchers describe the immunological features of the acute myeloid leukemia (AML) niche, with particular attention to the crosstalk between the AML blasts and the cellular components of the altered tumor microenvironment and the mechanisms of immune escape that hamper the therapeutic effects of the most advanced treatments.
In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.
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The California stem cell agency awarded $51 million to help train students in the art of research at the Golden State’s community colleges and universities.
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Scientists demonstrated that NAD+ metabolism enabled acute myeloid leukemia (AML) to evade apoptosis. They integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis.
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