Advances in Liver Cancer Stem Cell Isolation and their Characterization

Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
[Stem Cell Reviews and Reports]
Liu, L., & Borlak, J. (2021). Advances in Liver Cancer Stem Cell Isolation and their Characterization. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10114-6 Cite
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CD117/C-Kit Defines a Prostate CSC-Like Subpopulation Driving Progression and TKI Resistance

To determine how CD117 expression and activation by its ligand stem cell factor alters prostate cancer aggressiveness, researchers used C4-2 and PC3-mm human prostate cancer cells, which contained a CD117+ subpopulation.
[Scientific Reports]
Harris, K. S., Shi, L., Foster, B. M., Mobley, M. E., Elliott, P. L., Song, C. J., Watabe, K., Langefeld, C. D., & Kerr, B. A. (2021). CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance. Scientific Reports, 11(1), 1465. https://doi.org/10.1038/s41598-021-81126-6 Cite
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Prolactin Receptor-Driven Combined Luminal and Epithelial Differentiation in Breast Cancer Restricts Plasticity, Stemness, Tumorigenesis and Metastasis

The authors found that interfering with expression of the receptor for the lactogenic hormone prolactin in breast cancer cells representative of the luminal and epithelial breast cancer subtypes resulted in loss of their differentiation state, enriched for stem-like cell subpopulations, and increased their tumorigenic capacity in a subtype-specific manner.
[Oncogenesis]
Shams, A., Binothman, N., Boudreault, J., Wang, N., Shams, F., Hamam, D., Tian, J., Moamer, A., Dai, M., Lebrun, J.-J., & Ali, S. (2021). Prolactin receptor-driven combined luminal and epithelial differentiation in breast cancer restricts plasticity, stemness, tumorigenesis and metastasis. Oncogenesis, 10(1), 1–16. https://doi.org/10.1038/s41389-020-00297-5 Cite
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Interplay between Desmoglein2 and Hypoxia Controls Metastasis in Breast Cancer

Investigators found that high expression of desmoglein2, a component of desmosome-mediated intercellular adhesion complexes, promoted tumor growth, increased the prevalence of circulating tumor cell clusters, and facilitated distant organ colonization.
[Proceedings of the National Academy of Sciences of the United States of America]
Chang, P.-H., Chen, M.-C., Tsai, Y.-P., Tan, G. Y. T., Hsu, P.-H., Jeng, Y.-M., Tsai, Y.-F., Yang, M.-H., & Hwang-Verslues, W. W. (2021). Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2014408118 Cite
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ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
[Biomolecules]
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Glioma Stem Cells and Their Roles within the Hypoxic Tumor Microenvironment

Investigators summarize the impact of hypoxia and acidic stress on glioma stem cell signaling and biologic phenotypes, and potential methods to inhibit these pathways.
[Theranostics]
Boyd, N. H., Tran, A. N., Bernstock, J. D., Etminan, T., Jones, A. B., Gillespie, G. Y., Friedman, G. K., & Hjelmeland, A. B. (2021). Glioma stem cells and their roles within the hypoxic tumor microenvironment. Theranostics, 11(2), 665–683. https://doi.org/10.7150/thno.41692 Cite
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The Chick Chorioallantoic Membrane Model: A New In Vivo Tool to Evaluate Breast Cancer Stem Cell Activity

The authors established a CAM-LDA assay able to rapidly reproduce tumor specificities- in particular, the ability of the small population of cancer stem cells to form tumors.
[International Journal of Molecular Sciences]
Pinto, M. T., Ribeiro, A. S., Conde, I., Carvalho, R., & Paredes, J. (2021). The Chick Chorioallantoic Membrane Model: A New In Vivo Tool to Evaluate Breast Cancer Stem Cell Activity. International Journal of Molecular Sciences, 22(1), 334. https://doi.org/10.3390/ijms22010334 Cite
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Targeting of Glioma Stem-Like Cells with a Parthenolide Derivative ACT001 through Inhibition of AEBP1/PI3K/AKT Signaling

The effects of ACT001 on cell survival of normal human astrocytes and patient-derived glioma stem-like cells were evaluated. RNA-Seq were performed to detect differentially expressed genes.
[Theranostics]
Hou, Y., Sun, B., Liu, W., Yu, B., Shi, Q., Luo, F., Bai, Y., & Feng, H. (2021). Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling. Theranostics, 11(2), 555–566. https://doi.org/10.7150/thno.49250 Cite
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Circulating Tumor DNA Is Detectable in Canine Histiocytic Sarcoma, Oral Malignant Melanoma, and Multicentric Lymphoma

Researchers used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. They detected circulating tumor DNA in 21/23 of histiocytic sarcoma, 2/8of oral melanoma, and 12/13 of lymphoma cases.
[Scientific Reports]
Prouteau, A., Denis, J. A., De Fornel, P., Cadieu, E., Derrien, T., Kergal, C., Botherel, N., Ulvé, R., Rault, M., Bouzidi, A., François, R., Dorso, L., Lespagnol, A., Devauchelle, P., Abadie, J., André, C., & Hédan, B. (2021). Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma. Scientific Reports, 11(1), 877. https://doi.org/10.1038/s41598-020-80332-y Cite
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CCAAT/Enhancer-Binding Protein Delta Mediates Glioma Stem-Like Cell Enrichment and ATP-Binding Cassette Transporter ABCA1 Activation for Temozolomide Resistance in Glioblastoma

Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
[Cell Death Discovery]
Wang, S.-M., Lin, W.-C., Lin, H.-Y., Chen, Y.-L., Ko, C.-Y., & Wang, J.-M. (2021). CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma. Cell Death Discovery, 7(1), 1–11. https://doi.org/10.1038/s41420-020-00399-4 Cite
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A Nanotherapeutic Strategy to Overcome Chemotherapeutic Resistance of Cancer Stem-Like Cells

Investigators report a nanotherapeutic strategy to kill cancer stem cells in tumors using nanoparticles that were co-loaded with the differentiation-inducing agent, all-trans retinoic acid, and the chemotherapeutic drug, camptothecin.
[Nature Nanotechnology]
Shen, S., Xu, X., Lin, S., Zhang, Y., Liu, H., Zhang, C., & Mo, R. (2021). A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells. Nature Nanotechnology, 16(1), 104–113. https://doi.org/10.1038/s41565-020-00793-0 Cite
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