The authors identified homeobox B9 (HOXB9) as a critical regulator of metastatic metastatic prostate CSCs behavior.
[British Journal of Cancer]
Category Archives: Cancer Stem Cell
Cancer Stem Cell NewsCancer Stem Cell News is an online publication and email newsletter that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
Insights Into Homeobox B9: A Propeller for Metastasis in Dormant Prostate Cancer Progenitor Cells
Glioma Stem Cell-Derived Exosomal miR-944 Reduces Glioma Growth and Angiogenesis by Inhibiting AKT/ERK Signaling
Scientists investigated the regulatory role of exosomal miR-944 derived from glioma stem cells in glioma progression and angiogenesis.
[Aging]
Induction Therapy of Retinoic Acid with a Temozolomide-Loaded Gold Nanoparticle-Associated Ultrasound Effect on Glioblastoma Cancer Stem-Like Colonies
Researchers established a niche for glioblastoma stem-like cell selection as a platform and facilitate the assessment of differentiation therapy on glioblastoma multiforme cancer stem-like colonies by retinoic acid with temozolomide-loaded gold nanoparticles associated with low-intensity ultrasound.
[ACS Applied Materials & Interfaces]
LINC00115 Promotes Stemness and Inhibits Apoptosis of Ovarian Cancer Stem Cells by Upregulating SOX9 and Inhibiting the Wnt/β-Catenin Pathway through Competitively Binding to microRNA-30a
Long non-coding RNAs and miRs are differentially expressed in ovarian cancer (OC) cells and influence OC progression. Investigators explored the underlying roles of LINC00115 and miR-30a in OC.
[Cancer Cell International]
Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells’ Role in Tumor Progression
Scientists describe cancer-initiating cells’ (CICs) contribution to cancer progression.
[Stem Cell Reviews and Reports]
Extracellular Matrix Protein-1 Secretory Isoform Promotes Ovarian Cancer through Increasing Alternative mRNA Splicing and Stemness
Investigators reported that the secretory extracellular matrix protein-1 isoform induced tumorigenesis through the GPR motif binding to integrin αXβ2 and the activation of AKT/FAK/Rho/cytoskeleton signaling.
[Nature Communications]
Carcinoma Associated Fibroblasts Small Extracellular Vesicles with Low miR-7641 Promotes Breast Cancer Stemness and Glycolysis by HIF-1α
The roles of small extracellular vesicles (sEVs) from cancer-associated fibroblasts on breast cancer stem cell properties are largely unraveled. Investigators explored the roles of sEVs from cancer-associated fibroblasts on breast cancer progression.
[Cell Death Discovery]
3-Hydroxyanthranic Acid Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Decreasing Tumor Cell Stemness
Researchers demonstrated that 3-HAA sensitized hepatocellular carcinoma cells to sorafenib by reducing tumor stemness.
[Cell Death Discovery]
RBM5-AS1 Promotes Radioresistance in Medulloblastoma through Stabilization of SIRT6 Protein
Investigators profiled CSC-related long non-coding RNAs (lncRNAs) between radioresistant and parental medulloblastoma cells. The roles of the lncRNA RBM5-AS1 in the stemness and radiosensitivity of medulloblastoma cells were investigated.
[Acta Neuropathologica Communications]
Small Cell Lung Cancer Stem Cells Display Mesenchymal Properties and Exploit Immune Checkpoint Pathways in Activated Cytotoxic T Lymphocytes
To determine the immune-modulatory influence of CSC in small cell lung cancer (SCLC), scientists focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC.
[Cancer Immunology, Immunotherapy]
