Cleave Therapeutics Announces Commencement of a Phase I Clinical Study of CB-5339, A Valosin-Containing Protein (VCP)/p97 Inhibitor, in Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Cleave Therapeutics, Inc. announced that the first patient has been dosed with CB-5339 in a Phase I clinical trial of patients with relapsed/refractory AML or relapsed/refractory intermediate or high-risk MDS.
[Cleave Therapeutics, Inc.]
Press Release

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Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells

Researchers investigated the uptake behavior of various polymethine dyes on leukemia cell lines and searched for carrier proteins that guide dye transport using RNA interference.
[Molecular Therapy-Oncolytics]
AbstractGraphical Abstract

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Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
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miR-3622a-3p Acts as a Tumor Suppressor in Colorectal Cancer by Reducing Stemness Features and EMT through Targeting Spalt-Like Transcription Factor 4

The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
[Cell Death & Disease]
Chang, S., Sun, G., Zhang, D., Li, Q., & Qian, H. (2020). MiR-3622a-3p acts as a tumor suppressor in colorectal cancer by reducing stemness features and EMT through targeting spalt-like transcription factor 4. Cell Death & Disease, 11(7), 1–19. https://doi.org/10.1038/s41419-020-02789-z Cite
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French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
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Foreign Researchers Accused of Hiding Links to Chinese Military

Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist]
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Aberrantly Expressed Bruton’s Tyrosine Kinase Preferentially Drives Metastatic and Stem Cell-Like Phenotypes in Neuroblastoma Cells

Investigators found that Bruton’s tyrosine kinase was highly expressed in primary neuroblastoma samples, preferentially in MYCN-amplified neuroblastoma cases, and was associated with a poor prognosis.
[Cellular Oncology]
Abstract

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Combined Nanomedicines Targeting Colorectal Cancer Stem Cells and Cancer Cells

Using an engineered medium that enhanced the ratio of cancer stem cells (CSCs) in HCT116 cell cultures, researchers demonstrated by clonogenicity tests and in sphere assays that Salinomycin acted mainly on CSCs, while SN38 acted mainly on proliferating cancer cells.
[Journal of Controlled Release]
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MicroRNA‐124 Inhibits Stem‐Like Properties and Enhances Radiosensitivity in Nasopharyngeal Carcinoma Cells via Direct Repression of Expression of JAMA

Scientists investigated the role of miR‐124 in nasopharyngeal carcinoma (NPC) cancer stem cells. qRT‐PCR was performed to measure miR‐124 expression in NPC tissues and cell lines and the effects of miR‐124 on stem‐like properties and radiosensitivity of NPC cells measured.
[Journal of Cellular and Molecular Medicine]
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Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
[ScienceInsider]
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Glycosphingolipid Expression at Breast Cancer Stem Cells after Novel Thieno[2,3-B]Pyridine Anticancer Compound Treatment

Scientists performed studies of viability, type of cell death, cancer stem cell percent and glycosphingolipid expression on CSC and non-CSC after treatment of MDA-MB-231 and MDA-MB-453 triple-negative breast cancer cells with a newly developed thienopyridine anticancer compound.
[Scientific Reports]
Marijan, S., Markotić, A., Mastelić, A., Režić-Mužinić, N., Pilkington, L. I., Reynisson, J., & Čulić, V. Č. (2020). Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3- b ]pyridine anticancer compound treatment. Scientific Reports, 10(1), 11876. https://doi.org/10.1038/s41598-020-68516-y Cite
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Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
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